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WASTE Journal

Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Cytomegalovirus (CMV)-Specific Cell-Mediated Immunity for Prediction of Postprophylaxis CMV Disease in a Phase 3 Trial of Letermovir Versus Valganciclovir Prophylaxis in Donor CMV-Seropositive/Recipient CMV-Seronegative Kidney Transplant Recipients.

Limaye AP, Crespo M, Kamar N et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background QuantiFERON-cytomegalovirus (QFT-CMV) is a standardized assay for the evaluation of cytomegalovirus-specific cell-mediated immunity (CMV-CMI). Objectives The purpose of this study was to assess the evolution of CMV-CMI…

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Negative / Null Result ReportOpen accessMedicine

Identification of Factors Predicting False-Negative Results in Sentinel Lymph Node Biopsy in Patients Undergoing Surgery for Breast Cancer: A Single-Center Retrospective Study.

Bölük S, Bölük S · 2025 · Cureus

Background In breast cancer surgery, sentinel lymph node biopsy (SLNB) is routinely utilized for axillary assessment. Frozen section examination of the sentinel lymph node (SLN) is used to guide the decision for axillary dissection.…

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Negative / Null Result ReportMedicine

Optimizing HIV testing: Comparing diagnostic signatures and assay performance in ART-treated and general screening populations.

Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry

Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…

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Negative / Null Result ReportOpen accessMedicine

Polygenic risk scores in routine genetic diagnostics: what lies ahead?

Lauffer P, van Weelden W, van Haelst MM et al. · 2025 · Journal of community genetics

Polygenic risk scores (PRS) have emerged as a potential tool for predicting complex genetic traits and disorders, which may complement traditional rare variant testing. As genome-wide association studies (GWAS) expand, PRS predictive…

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Negative / Null Result ReportOpen accessMedicine

Effect of Nonsteroidal Anti-Inflammatory Drugs on Sacroiliac Joint Inflammation, as Seen on Magnetic Resonance Imaging, in Axial Spondyloarthritis.

Jones GT, Bennett AN, Sengupta R et al. · 2025 · Arthritis care & research

Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop…

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Negative / Null Result ReportOpen accessMedicine

Outcomes Related to Bacterial Co-Infection and Antibiotic Use in Adults Hospitalized With Respiratory Syncytial Virus Compared with Influenza.

Karlsen KL, Clausen CL, Kahiyah RAS et al. · 2026 · Open forum infectious diseases

Background Adults hospitalized with respiratory syncytial virus (RSV) face mortality risks comparable to or higher than those with influenza A or B. However, studies on the impact of bacterial co-infections on mortality are inconsistent.…

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Methods Dead-EndOpen accessMedicine

A drug-based model to predict hyponatremia in outpatients of a geriatric clinic.

van Orten-Luiten ACB, Brouwer-Brolsma EM, Janse A et al. · 2025 · European journal of clinical pharmacology

Purpose Chronic hyponatremia in older people is associated with adverse outcomes including gait disturbances, falls, osteoporosis, fractures, cognitive impairment, and cardiovascular disease. Diagnosis in outpatient settings is challenging…

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Negative / Null Result ReportMedicine

Impact of a Pharmacy-Driven (1,3)-β-D-Glucan Algorithm on Micafungin Duration of Therapy in the ICU.

Abi Kheir DJ, Moriles K, Carr AL et al. · 2026 · The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Background: The (1,3)-β-D-glucan (BDG) test can be used as a stewardship approach to decrease antifungal overutilization, development of resistance, and excess costs. Objective: This study assessed the impact that a BDG algorithm has on…

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Negative / Null Result ReportMedicine

Comparative analysis of laboratory-based and portable qPCR platforms: CFX, MIC, and Biomeme Franklin for African swine fever and avian influenza detection.

Auer A, Settypalli TBK, Rozstalnyy A et al. · 2026 · BMC veterinary research

Background Rapid diagnosis is critical for the early detection and control of transboundary animal diseases such as African Swine Fever (ASF) and Avian Influenza (AI), particularly because it enables timely containment measures at the farm…

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Negative / Null Result Report

Reliability of routine HPV testing in Burkina Faso: Laboratory quality control as part of the establishment of a laboratory network for the implementation of HPV testing

Zougmore WAMJ, Kaboré NF, Bado P et al. · 2026 · Preprint

Abstract Background : Human Papillomavirus (HPV) testing is recommended as a high-performance screening method within the World Health Organization (WHO) global strategy for cervical cancer elimination. However, the programmatic…

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Negative / Null Result Report

Sensitivity and Predictors of False-Negative SPECT Myocardial Perfusion Imaging in a High-Burden Coronary Artery Disease Population: A Retrospective Analysis Using Revascularization as the Reference Standard

Wright L, Hamze J, Nagrani TR et al. · 2026 · Preprint

Abstract Background Coronary artery disease (CAD) places a disproportionate burden on rural Appalachian communities. Scioto County, Ohio has among the highest rates of CAD-related hospitalizations in the state, approaching double the…

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Negative / Null Result ReportMedicine

Field study using sentinel birds and ELISA for differentiating infected from vaccinated animals (DIVA) in chicken flocks vaccinated with inactivated avian influenza H5 vaccines.

Ibrahim M, Mostafa D, Manie EA et al. · 2026 · British poultry science

1. This study used unvaccinated sentinels plus Avian Influenza Virus (AIV) specific ELISA for differentiating infected from vaccinated animals (DIVA). Birds assessed were from 10 broiler flocks (F1-F10), three layer (F11-F13) and two…

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Negative / Null Result ReportOpen accessMedicine

The impact of symptom duration on D-dimer: results from the Venous Thrombosis Registry in Østfold Hospital.

Tavoly M, Jørgensen CT, Sandblad KG et al. · 2026 · Research and practice in thrombosis and haemostasis

Background It has been suggested that D-dimer testing should be avoided in patients with prolonged symptoms, as results may yield false negatives. However, the evidence supporting this recommendation is limited. Objectives This study…

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Negative / Null Result ReportOpen accessMedicine

Reality check: testing the <i>in silico</i> predictions of false negative results due to mutations in SARS-CoV-2 PCR assays using templates with mismatches <i>in vitro</i>.

Otwell T, Knight B, Coryell M et al. · 2025 · Frontiers in cellular and infection microbiology

Molecular diagnostic assays are critical tools to test, diagnose and treat infectious and other diseases. For example, PCR test results have been extremely valuable during the COVID-19 pandemic, not only to provide appropriate health care…

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Negative / Null Result ReportMedicine

Diagnostic performance of somatostatin receptor positron emission tomography in preoperative evaluation of pancreatic neuroendocrine tumor lymph node metastases.

Gudmundsdottir H, Hernandez-Delima FJ, McDowell BC et al. · 2026 · Surgery

Background Regional lymph node involvement impacts prognosis for patients with pancreatic neuroendocrine tumors and may influence management decisions for small tumors. Conventional cross-sectional imaging modalities have low sensitivity…

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Negative / Null Result ReportOpen accessMedicine

Endogenous Biomarkers Analysis and False-Negative Results for SARSCov2 Using two Commercial RT-PCR Diagnostic Kits.

Khoshakhlagh M, Dehghani T, Alizadeh A et al. · 2026 · Iranian journal of pathology

Background & objective Real-time PCR is widely used to detect SARS-CoV-2, the virus responsible for COVID-19, but false-negative results can occur even with internal controls. This study aimed to investigate the impact of using alternative…

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