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Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Frequent Sugar-Sweetened Beverage Consumption, Dental Caries, and the Federal Poverty Level in Children 1-18 Years, NHANES 2015-2020.

Wiener RC, Abuhalimeh B, Cochran J · 2025 · Community dentistry and oral epidemiology

Objective The objective of this research was to determine if the ratio of family income to poverty index is a modifier in the relationship of sugar-sweetened beverages (SSB) and dental caries in U.S. children. Methods A cross-sectional…

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Negative / Null Result ReportOpen accessMedicine

Replicability or revision? Further evidence on the psychometric quality of the German version of the epistemic trust, mistrust and credulity questionnaire.

Schwarzer NH, Behringer N, Dees P et al. · 2026 · BMC psychology

Background The Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) assesses individual differences in epistemic stances. Although widely used, its German translation has not yet undergone an independent psychometric evaluation.…

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Negative / Null Result ReportMedicine

'July effect' in management and outcomes of patients admitted with pulmonary embolism in the United States, 2016 to 2021.

Bansal M, Mehta A, Morris DL et al. · 2025 · Proceedings (Baylor University. Medical Center)

Background This study sought to assess the outcomes of pulmonary embolism (PE) admissions at teaching and nonteaching hospitals in the month of July, when new trainees begin their training in the United States. Methods During 2016-2021,…

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Negative / Null Result ReportMedicine

Assessing the in vivo impact of novel β-lactamase inhibitors on the efficacy of their partner β-lactams against serine carbapenemase-producing Pseudomonas aeruginosa using human-simulated exposures.

Ruiz VH, Gill CM, Nicolau DP · 2024 · The Journal of antimicrobial chemotherapy

Objectives To evaluate the efficacy of human-simulated regimens (HSRs) of ceftazidime, ceftazidime/avibactam, imipenem, imipenem/relebactam, meropenem and meropenem/vaborbactam in a murine thigh infection model against serine…

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Negative / Null Result ReportOpen accessMedicine

Longitudinal Changes in Sensory Processing and Clinical Outcomes During Spinal Cord and Dorsal Root Ganglion Stimulation to Treat Chronic Pain: A Pilot Study.

Rogers ER, Sankarasubramanian V, Kyi WHT et al. · 2025 · Journal of pain research

Purpose The analgesic mechanisms and neurophysiological effects of spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS) are poorly understood. In this pilot repeated-measures study, we used quantitative sensory testing…

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Negative / Null Result ReportOpen accessMedicine

Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.

Stapley V, Anderson RS, Saunders K et al. · 2025 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Previous research suggests that the electroretinogram (ERG) is reduced and delayed in non-pathological myopia. However, the invasive nature of the electrode and cumbersome equipment required has prevented the widescale uptake…

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Negative / Null Result ReportOpen accessMedicine

Cleft Laterality Dental Arch Relationship Outcomes for Children with Unilateral Cleft Lip and Palate in New Zealand.

Fowler PV, Keall H, Kennedy D et al. · 2025 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectivesTo investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand.DesignA retrospective nationwide study.SettingsVirtual 3D orthodontic…

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Negative / Null Result ReportOpen accessMedicine

The Localization Accuracy of Electrically Evoked Dental Sensations.

Ashaibi NA, Mason AG, Hector MP et al. · 2025 · Clinical and experimental dental research

Objectives Dental pain of odontogenic origin can be difficult to accurately locate to a specific tooth. This study aimed to determine how effectively volunteers could locate electrical stimuli applied to teeth in both the anterior and…

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Negative / Null Result ReportOpen accessMedicine

Refining the clinical utility of [<sup>177</sup>Lu]Lu/[<sup>225</sup>Ac]Ac-PSMA tandem RLT in patients with metastatic castration resistant prostate cancer.

Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…

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Negative / Null Result ReportMedicine

Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report.

El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology

Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…

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Negative / Null Result ReportOpen accessMedicine

Rapid response to BRAF/MEK inhibitor therapy within 2 weeks for high-grade glioma with leptomeningeal metastasis: illustrative case.

Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons

Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…

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Negative / Null Result ReportMedicine

Gender-Affirming Hormone Therapy Is Associated with Increased Odds of Screening for Sexually Transmitted Infections in a Clinical Cohort of Transgender and Nonbinary Adults.

Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health

Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…

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Negative / Null Result ReportOpen accessMedicine

Derived hematological indices during peripheral blood stem cell mobilization in the plerixafor era: insightful dynamics but limited predictive value.

Murugesan M, Niveditha LP, Sindhu ER et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Derived hematological indices reflect immune activation, but their dynamics during the plerixafor era and their predictive value for stem cell yield remain unclear. Objectives To assess changes in derived hematological…

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