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WASTE Journal

Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Early computed tomography may miss main pancreatic duct injury in distal pancreatic trauma: a prospective surgically verified diagnostic accuracy study.

Tri PM, Hung NT, Liet DH et al. · 2026 · Emergency radiology

Purpose To assess the diagnostic performance of computed tomography (CT) for predicting main pancreatic duct injury in surgically explored patients with distal pancreatic trauma. Methods We conducted a prospective single-center diagnostic…

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Negative / Null Result ReportMedicine

[Evaluation of the screening performance of ultrasound for fatty liver using transient elastography in the elderly population of Shanghai communities].

Wei XT, Zhu LY, Wu YL et al. · 2026 · Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

Objective: To evaluate the screening performance and related factors of ultrasound for hepatic steatosis in community-based elderly populations using controlled attenuation parameter (CAP) measured by transient elastography as the…

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Negative / Null Result Report

Diagnostic Accuracy of Magnetic Resonance Imaging versus Computed Tomography for Lumbar Spondylolysis in Patients with Chronic Low Back Pain: A Single-Center Retrospective Study

TEZCE A, DURMUŞ E · 2026 · Preprint

Abstract Purpose The objective of this study is to compare the diagnostic efficacy of Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) in detecting lumbar spondylolysis among patients presenting with chronic low back pain, and…

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Negative / Null Result ReportOpen accessMedicine

Diagnostic and therapeutic impact of PCR in uveitis: real-world data from intraocular fluid analysis of 45 uveitis patients in a tertiary referral center in Turkey.

Zorlutuna Kaymak N, Pekel İ, Demir Tekol S et al. · 2026 · BMC ophthalmology

Purpose To evaluate the diagnostic utility and real-world clinical impact of polymerase chain reaction (PCR) analysis of aqueous humor (AH) and vitreous samples in patients with uveitis including suspected infectious and mixed…

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Negative / Null Result ReportOpen accessMedicine

The application value and limitations of metagenomic detection technology based on cerebrospinal fluid samples in suspected central nervous system infection: a retrospective study.

Feng Q, Liu B, Liu H et al. · 2025 · Frontiers in microbiology

Background Accurately diagnosing central nervous system (CNS) infections remains challenging. This study aimed to evaluate the effectiveness of metagenomic next-generation sequencing (mNGS) in diagnosing suspected CNS infections and its…

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Failed Experiment ReportOpen accessMedicine

Atypical superotemporal iris and retinal coloboma.

Patterson KN, Reynolds MM, Lueder GT · 2026 · American journal of ophthalmology case reports

Purpose To report our findings in a patient with an atypical case of supertemporal iris and retinal coloboma, and to assess its systemic associations and potential genetic causes. Observations A premature female infant born at 31 weeks…

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Negative / Null Result ReportOpen accessMedicine

Smear-positive Pulmonary Tuberculosis with False-negative Loop-mediated Isothermal Amplification and T-SPOT.TB Assays.

Tsutsumi Y, Nagasaki T, Muraki M et al. · 2026 · Internal medicine (Tokyo, Japan)

Rapid molecular and immunological assays for tuberculosis, including loop-mediated isothermal amplification (LAMP) and T-SPOT.TB assays, may yield false-negative results. We herein report a 62-year-old immunocompetent man with a productive…

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Negative / Null Result ReportOpen accessMedicine

Analytical performance of species-targeted quantitative PCR for intra-abdominal candidiasis in critically ill patients: a proof-of-concept post hoc analysis from the pBDG2 multicenter study.

Novy E, Schaeffer A, Nguyen M et al. · 2026 · Critical care (London, England)

BACKGROUND: Intra-abdominal candidiasis (IAC) is a severe form of invasive candidiasis that affects critically ill patients and is associated with a high mortality rate and persistent diagnostic delays. Conventional fungal culture from…

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Negative / Null Result ReportMedicine

A study of patient recall and comprehension of genetic testing results in amyotrophic lateral sclerosis (ALS).

Tomlinson J, Roberson E, Klee V et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration

Objective: Assess the accuracy of ALS patient recall of genetic testing results and evaluate comprehension of key implications of results. Methods: Participants were recruited from the Center for Disease Control's National ALS Registry. A…

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Negative / Null Result ReportMedicine

Metagenomic Next-generation Sequencing of Cerebrospinal Fluid: First-year Experience at a Tertiary Referral Hospital.

Alvarez Mulett S, Molina Garcia S, Abu Saleh O et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed. Traditional cerebrospinal fluid diagnostic methods for CNS infections have limited sensitivity.…

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Negative / Null Result ReportOpen accessMedicine

Diagnostic performance and clinical limitations of sentinel lymph node biopsy in head and neck melanoma: a 20-year retrospective cohort study.

Lükewille L, Wiegand S, Fazel A et al. · 2026 · Journal of cancer research and clinical oncology

Purpose Sentinel lymph node biopsy (SLNB) is a standard procedure for nodal staging in cutaneous melanoma. However, its diagnostic performance in the head and neck region remains limited due to complex lymphatic drainage patterns. This…

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Negative / Null Result ReportMedicine

[Analysis of false-negative cases by Optical genome mapping and a literature review].

Zhang J, Su M, Zhang Y et al. · 2025 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To explore the reasons for false negative results by Optical genome mapping (OGM) analysis of three cases and propose strategies for handling them. Methods Three patients presented at the Affiliated Hospital of Nantong University…

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Negative / Null Result ReportMedicine

Cross-resistance of Belinostat and Romidepsin in Non-T Follicular Helper Peripheral T-cell Lymphoma Models Suggests Subtype-Specific Implications for Belinostat-CHOP.

Pantazis JC, Palmer AC · 2026 · Molecular cancer therapeutics

The phase III study of romidepsin plus CHOP for peripheral T-cell lymphoma (PTCL) yielded negative results in the overall analysis and showed that outcomes were only improved in the T follicular helper (TFH) subgroup of PTCL, with no…

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Negative / Null Result ReportMedicine

[Expert consensus on newborn genetic screening process, interpretation of results, and recall (2026 Edition)].

Genetic And Metabolic Disorders Screening Subgroup Of The Birth Defects Prevention And Control Committee Chinese Preventive Medicine Association, Rare Diseases Branch Of Shandong Medical Association, Genetic Metabolism Branch Of Shandong Provincial Rare Disease Association et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

High-throughput sequencing technology has recently been used in neonatal disease screening. To address the issues related to the screening process, interpretation of screening results, and recall of positive cases in neonatal genetic…

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Negative / Null Result ReportMedicine

18F choline PET/MR to assess clinically significant disease in prostate cancer: correlation with maximum and total cancer core length obtained via template mapping biopsies.

Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications

Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…

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Negative / Null Result ReportOpen accessMedicine

The sonographic Murphy sign: does analgesia matter?

Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology

Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…

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Failed Experiment ReportOpen accessMedicine

Comprehensive Cytogenetic Analysis Reveals Mosaicism in Newborn with Negative Prenatal Down Syndrome Screening: A Case Report.

Puppo I, Vardanyan A, Shahsuvaryan G et al. · 2025 · The American journal of case reports

BACKGROUND Down syndrome, or trisomy 21, is one of the most common chromosomal disorders associated with intellectual disability. Prenatal screening is a proactive approach to identify fetuses with common chromosomal abnormalities.…

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Negative / Null Result ReportOpen accessMedicine

Interpreting the drop: concordance and disparity between a new point-of-care assay and laboratory intraoperative parathyroid hormone testing in parathyroid surgery.

Kwatra D, Wakeford W, Ally M et al. · 2026 · BMC endocrine disorders

BACKGROUND: To evaluate the concordance of the NBCL CONNECT Point-of-Care (POC) Intraoperative Parathyroid Hormone (IOPTH) assay with a Central Laboratory standard, with a focus on percentage drops and the usefulness of POC testing in…

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Negative / Null Result ReportMedicine

Colostrum-derived immunity reduces detection of calves persistently infected with bovine viral diarrhea virus by common diagnostic tests.

Saucedo M, Chamorro MF, Passler T et al. · 2026 · Journal of the American Veterinary Medical Association

Objective This study aimed to compare the most accurate sample type, test, and timing for detecting bovine viral diarrhea virus (BVDV) in persistently infected (PI) calves at different time points following birth and colostrum intake.…

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Negative / Null Result ReportOpen accessMedicine

Disseminated Histoplasmosis and Aortic Valve Infective Endocarditis in a Patient With Recent Aortobifemoral Bypass.

Behjatnia H, Couto P, Castillo Y et al. · 2026 · The American journal of case reports

BACKGROUND Fungal endocarditis constitutes up to 3% of diagnosed infective endocarditis cases, and Histoplasma spp. cause approximately 10% of fungal endocarditis cases. Histoplasma infection occurs through inhalation of spores typically…

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Negative / Null Result ReportOpen accessMedicine

Concurrent <i>EGFR</i> L858R and K860I mutations: PCR-negative but NGS-positive alterations that respond to <i>EGFR</i> inhibitors in non-small cell lung cancer.

Shi H, Li W, Guo L et al. · 2025 · Journal of thoracic disease

Background Both amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and next-generation sequencing (NGS) are able to identify sensitizing epidermal growth factor receptor ( EGFR ) mutations of non-small cell lung…

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