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Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Dynamic lactation responses to dietary crude protein oscillation in diets adequate and deficient in metabolizable protein in Holstein cows.

Erickson MG, Zanton GI, Wattiaux MA · 2023 · Journal of dairy science

Limited research has examined the interaction between dietary crude protein (CP) level and CP feeding pattern. We tested CP level (low protein [LP], 13.8%; high protein [HP], 15.5% CP, dry matter [DM] basis) and CP feeding pattern (OF =…

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Negative / Null Result ReportMedicine

Odor-Color Associations Are Not Mediated by Concurrent Verbalization.

Speed LJ, de Valk J, Croijmans I et al. · 2023 · Cognitive science

Odor and color are strongly associated. Numerous studies demonstrate consistent odor-color associations, as well as effects of color on odor perception and language. Yet, we know little about how these associations arise. Here, we test…

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Failed Experiment ReportOpen accessMedicine

A Phase II Study of Abemaciclib for Patients with Retinoblastoma-Positive, Metastatic Triple-Negative Breast Cancer.

Goel S, Jovanović B, Chu X et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Cyclin-dependent kinase 4/6 inhibitors can significantly extend survival when given in combination with endocrine therapy in patients with hormone receptor-positive metastatic breast cancer. However, their activity has been…

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Failed Experiment ReportMedicine

Add-On Prostaglandin E 1 in Venovenous Extracorporeal Membrane Oxygenation: A Randomized, Double-Blind, Placebo-controlled Pilot Trial.

Buchtele N, Schörgenhofer C, Schwameis M et al. · 2022 · American journal of respiratory and critical care medicine

Rationale: Prostaglandin E 1 (alprostadil; PGE 1 ), in addition to low-dose unfractionated heparin, increases the biocompatibility of extracorporeal systems and enhances the efficacy of artificial organs without increasing bleeding risk.…

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Methods Dead-EndOpen accessMedicine

Cost-effectiveness of lurbinectedin with atezolizumab for extensive-stage small-cell lung cancer in the United States: impact of drug wastage reduction on economic outcomes.

Zhu J, Li Z, Song D et al. · 2026 · BMC health services research

Background The IMforte trial had supported lurbinectedin as a recommended first-line maintenance therapy for patients with extensive-stage small-cell lung cancer (ES-SCLC), while its cost-effectiveness remains uncertain for patients and…

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Failed Experiment ReportOpen accessMedicine

TRAbectedin in adVanced rEtroperitoneal well differentiated/dedifferentiated Liposarcoma and Leiomyosarcoma (TRAVELL): results of a phase II study from the Italian Sarcoma Group.

Fabbroni C, Grignani G, Vincenzi B et al. · 2024 · ESMO open

Background This is a multicentre, single-arm, phase II study aimed at further exploring the activity of trabectedin as second-/further-line treatment in retroperitoneal leiomyosarcoma (LMS) and well-differentiated/dedifferentiated…

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Failed Experiment ReportOpen accessMedicine

Investigating the effects of antipsychotic drugs as a treatment for improving the activity of the unc-33 /Dpysl2 gene in C. elegans .

Miranda MC, Hyde J, Salazar K et al. · 2024 · microPublication biology

Prenatal stress is hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined that prenatal stress in rats decreases levels of Dpysl2, which is found to be inactivated in schizophrenic patients. UNC-33 ,…

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Negative / Null Result ReportOpen accessMedicine

Overuse-Induced Muscle Disorder: Establishing a Rat Model to Unravel the Role of Fibro-Adipogenic Progenitor Cells in Intramuscular Fibrosis.

Fusagawa H, Sato T, Naito A et al. · 2025 · Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Overuse-induced muscle disorders (OIMD) frequently occur in athletes due to excessive and improper use under high physical demand, often leading to muscle pain and weakness. Limited studies have shown intramuscular fibrosis in OIMD, with…

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Negative / Null Result ReportOpen accessMedicine

Trait emotion regulation similarity and well-being.

Eldesouky L, Gross JJ, English T · 2025 · Scientific reports

The ways people manage their emotions (emotion regulation; ER) have been found to affect their own well-being and the well-being of others. In the present research, we extended prior work by examining whether similarity between people's ER…

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Negative / Null Result ReportOpen accessMedicine

Experimentally induced sleep restriction relates to less healthy eating behaviors in some adolescents: effects of age, sex, race, weight class, and socioeconomic status.

Hernandez C, Jensen CD, Duraccio KM · 2025 · Sleep advances : a journal of the Sleep Research Society

Study objectives This secondary data analysis study was designed to evaluate demographic and socioeconomic characteristics that may increase the magnitude of the impact of experimentally induced shortened sleep on suboptimal eating…

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Negative / Null Result ReportMedicine

Impact of acute sleep restriction on cerebrovascular reactivity and neurovascular coupling in young men and women.

McDonald MJ, Marsh ML, Fears SD et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)

Chronic exposure to shortened sleep is associated with an increased risk of Alzheimer's disease and dementia. Previous studies show insufficient (e.g., poor or fragmented) sleep impairs cerebrovascular reactivity to metabolic stress and…

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