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Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of copper and iron on the oxidation of vegetable oil during aging

Randhawa S, Mukherjee T · 2025 · Journal of Food Composition and Analysis.

The research paper investigates how elemental copper and iron, affect the aging process of canola, coconut, groundnut, rice bran, soybean, and sunflower oils. Samples analysed biannually over two years indicate that the addition of copper,…

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Negative / Null Result ReportMedicine

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

Borges CC, Alves da Silva W, de Sá Filho AS et al. · 2026 · International journal of sport nutrition and exercise metabolism

This study aimed to evaluate the effects of short-term oral L-arginine (ARG) supplementation on vascular parameters, nitric oxide (NO) concentration, and muscular performance during upper limb resistance exercise in healthy young men. A…

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Negative / Null Result Report

Metabolic interoceptive rewards shape affect, but not action

Fleming HA, Whines A, Whelehan P et al. · 2025 · Preprint

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

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Negative / Null Result ReportOpen accessMedicine

Biomechanical evaluation of patch augmentation in a rotator cuff repair model using a porcine flexor digitorum profundus tendon: influence of knot tying and time-zero stability.

Rhee SM, Cho CH, Kim M et al. · 2025 · Clinics in shoulder and elbow

Background This study evaluates the biomechanical effects of acellular dermal matrix (ADM) patch augmentation in a rotator cuff repair model and determines the effect of medial knot tying on time-zero stability. Methods A biomechanical…

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Negative / Null Result ReportMedicine

A Simplified and Data-Driven Lung Ultrasound Approach for Predicting Surfactant Need in Preterm Infants: A Pilot Study Using Machine Learning and Rule-Based Models.

Meau-Petit V, Mottez C, Bhojnagarwala B et al. · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Objectives Six-region lung ultrasound (LUS) scores show good predictive value for predicting surfactant need in preterm infants but rely on a fixed threshold, which may lead to misclassification near the cut-off and lack data-driven…

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Negative / Null Result ReportOpen accessMedicine

Correlation between systemic blood pressure and free flap perfusion: A photoplethysmography study.

Sahu SA, Mishra JK, De M et al. · 2026 · GMS Interdisciplinary plastic and reconstructive surgery DGPW

Background Microvascular tissue transfer is the method of choice for oncological and trauma reconstruction. Successful free tissue transfer requires technical expertise and management of patients and surgery related factors. However,…

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Negative / Null Result ReportMedicine

Does Hypnosis Aid Memory Retrieval?: A Review of Steven Jay Lynn's Research.

Krackow E, Rashed J, Thompson I · 2025 · The International journal of clinical and experimental hypnosis

Steven Jay Lynn was one of the most prolific clinical psychologists who made major contributions to the scientific literature in numerous areas, including in the area of hypnosis and memory. We review this work, limited to studies…

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Negative / Null Result Report

Putting the testing effect to the test in the wild: Retrieval enhances real-world memories and promotes their semantic integration while preserving episodic integrity

Homann LA, Jahed M, Barense M · 2025 · Preprint

Retrieval practice—actively recalling information—is an established memory-strengthening technique. However, understanding how retrieval transforms memory requires examining its effects on memories that evolve across multiple episodic and…

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Negative / Null Result Report

Putting the testing effect to the test in the wild: Retrieval enhances real-world memories and promotes their semantic integration while preserving episodic integrity

Homann LA, Jahed M, Barense M · 2025 · Preprint

Retrieval practice—actively recalling information—is an established memory-strengthening technique. However, understanding how retrieval transforms memory requires examining its effects on memories that evolve across multiple episodic and…

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Negative / Null Result ReportMedicine

Effects of Combined Intragastric Administration of Quinine with L-Leucine or L-Isoleucine on the Glycemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Healthy Males.

Sajjad M, Ghorbaninejad P, Bitarafan V et al. · 2026 · The Journal of nutrition

Background The amino acids, L-leucine (Leu) and L-isoleucine (Ile), and the bitter substance, quinine, reduce postprandial glucose, stimulate insulin, and/or slow gastric emptying. Whether combining these stimuli can enhance these effects…

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Negative / Null Result ReportMedicine

Antileishmanial Activity of Oseltamivir and Acyclovir: Modulation of Macrophage Phagocytosis and Cytotoxicity Assessment.

Lima Neta PP, Leal PPMS, Passos VHAA et al. · 2025 · Anais da Academia Brasileira de Ciencias

Leishmaniasis is a group of diseases caused by protozoa of the genus Leishmania . Current treatments exhibit high toxicity, high costs, and parasite resistance. Consequently, the search for new drugs is of utmost importance, and drug…

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Negative / Null Result ReportMedicine

Comparative Analysis of Intrathecal Lidocaine Combined With Guanfacine or Dexmedetomidine on Nociceptive and Motor Blockade in Rats.

Chou AK, Chiu CC, Chen YW et al. · 2025 · Fundamental & clinical pharmacology

The aim of this study was to examine the effects of intrathecal lidocaine combined with guanfacine or dexmedetomidine on nociceptive and motor blockade, in comparison to clonidine. Using a rat model of intrathecal injection, we evaluated…

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Negative / Null Result ReportMedicine

Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model

Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and Biophysical Research Communications

In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…

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Negative / Null Result ReportMedicine

Reevaluating diagnostic confidence: the impact of delayed excretory phase imaging in CT urography on detecting renal and urinary tract abnormalities.

Firoozeh N, Park SY, Basavalingu D et al. · 2026 · Abdominal radiology (New York)

Objective To assess the diagnostic value of the delayed excretory phase in computed tomography urography (CTU) for detecting renal and urinary tract abnormalities and its impact on readers' confidence in patients with hematuria, given…

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Negative / Null Result ReportMedicine

Commercial cytokine assay on equine cerebrospinal fluid does not distinguish equine degenerative myeloencephalopathy from cervical vertebral stenotic myelopathy.

Payette F, Kulp JC, Graves A et al. · 2025 · American journal of veterinary research

Objective To measure and compare CSF cytokine concentrations among horses with equine neuroaxonal dystrophy (eNAD)/equine degenerative myeloencephalopathy (EDM), horses with cervical vertebral stenotic myelopathy (CVSM), and control horses…

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Negative / Null Result ReportMedicine

Moderate intermittent hypoxic conditioning to enhance cerebrovascular function in the elderly: a randomized controlled trial.

Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…

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Negative / Null Result ReportMedicine

Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality.

Bonsu KO, Young SW, Lee T et al. · 2025 · Seminars in thrombosis and hemostasis

Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study…

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