Negative / Null Result ReportMedicine
Tavares, Ramalho, da Silva et al. · 2026 · Breast cancer research and treatment
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by early relapse and limited therapeutic options. Carboplatin added to anthracycline/taxane neoadjuvant chemotherapy (NACT) raises pathologic complete response…
View details →Negative / Null Result ReportMedicine
Caldonazo, Scheler, Fischer et al. · 2026 · American heart journal plus : cardiology research and practice
Device-associated endocarditis is a potentially life-threatening condition that typically requires the removal of the cardiac implantable electronic device (CIED). The role of routine coronary angiography (CAG) as part of preoperative…
View details →Negative / Null Result ReportMedicine
Alzraikat, Al-Hiyasat, Jamous et al. · 2026 · Biomaterial investigations in dentistry
This study evaluated the effectiveness of acids on calcium silicate cement surface hardness, perforation, and their impact on root dentine microstructure. Root dentine discs were exposed to hydrochloric, acetic, and citric acids. Fourier…
View details →Negative / Null Result ReportMedicine
Chen, Ma, Zhang · 2026 · Accident; analysis and prevention
Automated vehicles (AVs) are designed to improve traffic safety, mobility, and driver comfort; however, their benefits depend on the widespread adoption of AVs. As full market penetration remains unlikely in the near term, AVs will…
View details →Negative / Null Result ReportMedicine
Atef Abdelsattar Ibrahim, Gouda Kamal, Zid et al. · 2026 · World journal of clinical pediatrics
Obesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability (HRV), a non-invasive indicator of cardiovascular risk. Omega-3 polyunsaturated fatty acids have…
View details →Negative / Null Result ReportMedicine
Yıldız, Top, Yıldız et al. · 2026 · Mediterranean journal of hematology and infectious diseases
Stenotrophomonas maltophilia ( S. maltophilia ) is a multidrug-resistant pathogen frequently isolated in hospital-acquired pneumonia and represents a significant clinical challenge. This study aimed to investigate the risk factors…
View details →Short NoteMedicine
Narimichi, Komaki, Suzuki et al. · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Solar UV comprises UVA and UVB; each exerts distinct biological effects, while their combined impact is not yet fully understood. We previously reported that human keratinocytes exposed to UVA1 followed by UVB irradiation exhibited severe…
View details →Negative / Null Result ReportMedicine
Timothee, Bliss, Blumenthal et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary…
View details →Negative / Null Result ReportMedicine
Kacar, Ayaz-Alkaya · 2026 · Journal of pediatric nursing
Internet addiction is a growing problem among children and adolescents. Pathological internet use may lead to psychological and social issues. More effective and innovative interventions are needed to promote the mental health of children.…
View details →Negative / Null Result ReportMedicine
Lopes, Costa, Nociti Junior et al. · 2026 · Brazilian oral research
This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondrial metabolic…
View details →Negative / Null Result ReportMedicine
Linke, Mayer, Suttkus et al. · 2026 · Pediatric research
This study examined parental stress indicators during outpatient pediatric surgery and whether intraoperative text messaging could alleviate stress. This randomized trial assigned parents of children aged 6 months to 6 years undergoing…
View details →Negative / Null Result ReportMedicine
Melnikova · 2025 · Bulletin of experimental biology and medicine
Using in vivo microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid…
View details →Negative / Null Result ReportMedicine
Nazki, Tennakoon, Reddy et al. · 2026 · The Journal of general virology
Infectious bursal disease virus (IBDV) causes an endemic immunosuppressive disease in chickens. Prior exposure to IBDV influences the pathogenesis and shedding of chicken strains of influenza A virus (IAV), but its effect on waterfowl…
View details →Negative / Null Result ReportMedicine
Tuncekin, Toprak · 2026 · Iranian journal of immunology : IJI
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic autoimmune inflammatory disorders in which TNF-α plays a key role. Anti-TNF agents are widely used in the management of these diseases. Since TNF-α is also…
View details →Negative / Null Result ReportMedicine
Xu, Hu, Zhao et al. · 2026 · Obesity (Silver Spring, Md.)
HDM1002, a small-molecule agonist of glucagon-like peptide-1 receptors, was evaluated for safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD). Chinese participants (18-60 years) with…
View details →Negative / Null Result ReportMedicine
Elgayar · 2026 · Scientific reports
This trial aimed to explore the effect of supervised breathing exercises (BEs) on depression, sexual function, and exercise capacity in postmenopausal women. Sixty-four depressed postmenopausal women with associated sexual dysfunction were…
View details →Failed Experiment ReportMedicine
Chen, Liu, Xue et al. · 2026 · Molecular pain
The insular cortex (IC), a critical hub for nociception, emotion, and cognition processing, has emerged as a key role in the descending modulation of spinal cord excitability. Although previous studies have suggested that IC may influence…
View details →Short NoteMedicine
Balducci, Haxhi, Vitale et al. · 2026 · Acta diabetologica
To assess the effect of a 1-year supervised exercise training program on long-term mortality in people with type 2 diabetes. This is a post hoc analysis of the Italian Diabetes and Exercise Study randomized clinical trial, which enrolled…
View details →Methods Dead-EndMedicine
Zhang, Song, Ji et al. · 2026 · Ecotoxicology and environmental safety
The rise in electronic waste from the electronics industry has increased environmental and health risks. Pollutants like tris(2-chloroethyl) phosphate (TCEP) and lead (Pb) are particularly concerning for their harmful effects on…
View details →Negative / Null Result ReportMedicine
Rezaeinejad, Sepidarkish, Moini et al. · 2026 · Pregnancy hypertension
While cigarette smoking has been paradoxically associated with a reduced risk of preeclampsia, the effect of waterpipe (WP) smoking, an increasingly prevalent form of tobacco use remains poorly understood. This study aimed to investigate…
View details →Negative / Null Result ReportMedicine
Ehne, Kastensson, Wedin et al. · 2026 · Journal of bone oncology
The use of postoperative radiotherapy (PORT) as an adjunct to orthopaedic surgery of the long bones is widely recommended. Evidence of the benefits is however sparse. The primary research question of this study was whether PORT reduces the…
View details →Negative / Null Result ReportMedicine
Karunayawong, Sukmanee, Butchon et al. · 2026 · BMJ open
Since 1985, the international healthcare community has recommended the ideal rate of caesarean section (CS) to be 10%-15% at the national level. The literature has reported that overused CS without necessary medical indications can be…
View details →Abandoned HypothesisMedicine
Li, Hou, Li et al. · 2026 · Chemistry & biodiversity
Two new pyrrole alkaloids, asiaticain A (1) and asiaticain B (2), two aromatic compounds 3-4, and one steroid 5 were isolated from Lanmaoa asiatica. The structural elucidation of the isolated compounds was determined by using NMR, MS, IR,…
View details →Negative / Null Result ReportMedicine
Rodrigues, Macedo, de Paulo et al. · 2026 · Oral surgery, oral medicine, oral pathology and oral radiology
To evaluate the effects of sticky bone a biomaterial composed of Solid-PRF (S-PRF), a variant of platelet-rich fibrin (PRF), and deproteinized bovine bone-on bone formation after tooth extraction performed prior to radiotherapy, with…
View details →Negative / Null Result ReportMedicine
Olivieri, Amatori, Battocchio et al. · 2026 · Nanomaterials (Basel, Switzerland)
Gold nanorods (AuNRs) were synthesized and optimized with the aim of obtaining strongly hydrophilic nanomaterials, suitable as a drug delivery system (DDS) for copper-based drugs. After careful purification, AuNRs were characterized by…
View details →Methods Dead-EndMedicine
Vrinzen, Stadhouders, Bloemendal et al. · 2026 · BMJ open
Concentration of care and collaborations between hospitals increasingly reorganise oncological care into Comprehensive Cancer Networks (CCNs), aiming to improve care outcomes and reduce costs. This study aims to evaluate the effect of four…
View details →Short NoteMedicine
Pellerito, Dowling, Luke et al. · 2026 · Thrombosis research
Post thrombotic syndrome is a fibrotic disease related to inflammation resolution. There are no direct therapies that can ameliorate this disease. Monocyte/macrophages (Mo/MØ) are the primary leukocyte involved with later venous…
View details →Negative / Null Result ReportMedicine
Bregen, de Buhr, Strutzberg-Minder et al. · 2026 · Veterinary sciences
The reasons for disease outbreaks caused by Actinobacillus pleuropneumoniae (APP) in vaccinated pigs are often unknown and remain a challenge for farmers and veterinarians. One hypothesis for APP vaccine failure is the timing of APP…
View details →Negative / Null Result ReportMedicine
Wang, Ouyang, Chen et al. · 2026 · Scientific reports
This study aims to explore the impact of wearing Defocus Incorporated Multiple Segments (DIMS) spectacle lenses on astigmatism in myopic children. This study included 396 myopic children and divided the participants into two groups:the…
View details →Negative / Null Result ReportMedicine
Ma, Qiu, Liu · 2025 · Frontiers in nutrition
Acute-on-chronic liver failure (ACLF) patients face high risks of nutritional risk and clinical complications, but whether adjuvant nutritional support reduces adverse complications remains unclear. This study included 6,097 hospitalized…
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