21,216 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss et al. · 2019 · The FASEB Journal
While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally…
View details →Ai Milojevic, Ben Armstrong, Masahiro Hashizume et al. · 2011 · Epidemiology
BACKGROUND: There is little information available on nontraumatic health risks as the result of floods, and on the factors that determine vulnerability to them (especially in low-income settings). We estimated the pattern of mortality,…
View details →Shari L. Barkin, William J. Heerman, Evan C. Sommer et al. · 2018 · JAMA
Importance: Prevention of obesity during childhood is critical for children in underserved populations, for whom obesity prevalence and risk of chronic disease are highest. Objective: To test the effect of a multicomponent behavioral…
View details →David D. Luxton, Larry D. Pruitt, Amy W. Wagner et al. · 2016 · Journal of Consulting and Clinical Psychology
OBJECTIVE: Evidence of feasibility, safety, and effectiveness of home-based telebehavioral health (HBTBH) needs to be established before adoption of HBTBH in the military health system can occur. The purpose of this randomized controlled…
View details →Nichole D. Mahnert, Daniel M. Morgan, Darrell A. Campbell et al. · 2015 · Obstetrics and Gynecology
OBJECTIVE: To define the incidence of unexpected gynecologic malignancies among women who underwent hysterectomy for benign indications. METHODS: We conducted a data analysis of hysterectomy cases from a quality and safety database…
View details →Satoshi Ishikawa, Hiromitsu Hayashi, Kouichi Kinoshita et al. · 2013 · International Journal of Cancer
While statin intake has been proven to reduce the risk of colorectal cancer (CRC), the mechanism of antitumor effects and clinical significance in survival benefits remain unclear. Statin-induced antiproliferative effects and its…
View details →Heath D. Skinner, Chen Hu, Theodoros Tsakiridis et al. · 2021 · JAMA Oncology
IMPORTANCE: Non-small cell lung cancer (NSCLC) has relatively poor outcomes. Metformin has significant data supporting its use as an antineoplastic agent. OBJECTIVE: To compare chemoradiation alone vs chemoradiation and metformin in stage…
View details →Elizabeth L. Stegemöller, Hollie Radig, Paul R. Hibbing et al. · 2016 · Disability and Rehabilitation
Purpose Interventions focused on singing may provide additional benefits to established voice and respiratory therapies, due to their greater emphasis on the respiratory muscle control system in those with Parkinson's disease (PD)…
View details →Zhonglei He, Kangze Liu, Eline Manaloto et al. · 2018 · Scientific Reports
Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains challenging. Cold atmospheric plasma (CAP) can be combined with AuNP to achieve synergistic anti-cancer cytotoxicity. To explore synergistic mechanisms, we demonstrate both rate of AuNP uptake and total amount accumulated in U373MG Glioblastoma multiforme (GBM) cells are significantly increased when exposed to 75 kV CAP generated by dielectric barrier discharge. No significant changes in the physical parameters of AuNP were caused by CAP but acti
View details →Aaron K. Remenschneider, Sarah Lookabaugh, Avner Aliphas et al. · 2014 · Otology & Neurotology
OBJECTIVE: Otologic trauma was the most common physical injury sustained after the April 15, 2013, Boston Marathon bombings. The goal of this study is to describe the resultant otologic morbidity and to report on early outcomes. STUDY…
View details →Patrick L. Kelly, Ori D. Fox, Alexei V. Filippenko et al. · 2014 · The Astrophysical Journal
We constrain the properties of the progenitor system of the highly reddened Type Ia supernova (SN Ia) 2014J in Messier 82 (M82; d ≈ 3.5 Mpc). We determine the supernova (SN) location using Keck-II K-band adaptive optics images, and we find…
View details →Teng Moua, Ana Carro Martínez, Misbah Baqir et al. · 2014 · Respiratory Research
BACKGROUND: Although usual interstitial pneumonia (UIP) appears to portend better survival when associated with connective tissue disease (CTD-UIP), little is known about the presenting clinical, radiologic, and pathologic features that differentiate pathologically confirmed UIP with CTD from idiopathic pulmonary fibrosis (IPF). In patients with atypical radiologic and clinical features, what specific findings predict underlying IPF vs. CTD-UIP diagnosis and their respective long term survival? METHODS: A large retrospective cohort analysis was done of consecutive patients seen from 1995 throu
View details →James Chih‐Hsin Yang, Dae Ho Lee, Jong Seok Lee et al. · 2023 · Journal of Clinical Oncology
LBA9000 Background: EGFR TKIs are standard 1L therapy for metastatic NSCLC with sensitizing EGFR mutations; however, most patients (pts) ultimately experience PD. We report the protocol-specified final analysis (FA) from the randomized,…
View details →Jiang He, Marion R. Wofford, Kristi Reynolds et al. · 2011 · Circulation
BACKGROUND: Observational studies have reported an inverse association between dietary protein intake and blood pressure (BP). We compared the effect of soy protein, milk protein, and carbohydrate supplementation on BP among healthy…
View details →Mark R. Petersen, Daniel Livescu · 2010 · Physics of Fluids
Linear forcing has been proposed as a useful method for forced isotropic turbulence simulations because it is a physically realistic forcing method with a straightforward implementation in physical-space numerical codes [T. S. Lundgren,…
View details →Chipote Precious · 2014 · Mediterranean Journal of Social Sciences
This paper explores the role played by monetary policy in promoting economic growth in the South African economy over the period 2000-2010. The study employs the Augmented Dickey-Fuller and Phillips Perron unit root tests to test for…
View details →Brady T. West, Kristen Olson · 2010 · Public Opinion Quarterly
classical intra-interviewer correlation (q int ) provides survey researchers with an estimate of the effect of interviewers on variation in measurements of a survey variable of interest. This correlation is an undesirable product of the…
View details →Christian O. Dimkpa, Trevor Hansen, Jacob Stewart et al. · 2014 · Nanotoxicology
Nanoparticles (NPs) incorporated into commercial products are reactive on plants. Here, the influence of a root-associated bacterium, Pseudomonas chlororaphis O6 (PcO6) on the responses of bean (Phaseolus vulgaris) to commercial ZnO…
View details →Gabriel Fitzpatrick, Florian Vogt, Osman Gbabai et al. · 2015 · The Journal of Infectious Diseases
This paper describes patient characteristics, including Ebola viral load, associated with mortality in a Médecins Sans Frontières Ebola case management centre (CMC).Out of 780 admissions between June and October 2014, 525 (67%) were…
View details →Duc Hong Vo, Anh The Vo · 2021 · Energy Sustainability and Society
Abstract The energy–environment–growth nexus has been examined for the Association of Southeast Asian Nations (ASEAN) region, mainly using time series data. However, the important role of renewable energy and population has largely been ignored in previous studies. As such, this study is conducted to investigate a causal link between renewable energy usage, population, carbon dioxide emissions, and economic growth. In addition, a relatively new and advanced panel vector autoregressive model and the Granger non-causality test for heterogeneous panels are utilized with a sample of seven ASEAN co
View details →Seung Joo Kang, Charleston W. K. Chiang, C. D. Palmer et al. · 2010 · Human Molecular Genetics
Genome-wide association (GWA) studies have identified common variants that are associated with a variety of traits and diseases, but most studies have been performed in European-derived populations. Here, we describe the first genome-wide…
View details →Nate Kornell, Patricia Jacobs Klein, Katherine A. Rawson · 2014 · Journal of Experimental Psychology Learning Memory and Cognition
Retrieving information from memory enhances learning. We propose a 2-stage framework to explain the benefits of retrieval. Stage 1 takes place as one attempts to retrieve an answer, which activates knowledge related to the retrieval cue.…
View details →Brooke N. Macnamara, Megha Maitra · 2019 · Royal Society Open Science
We sought to replicate Ericsson, Krampe & Tesch-Römer's (Ericsson, Krampe & Tesch-Römer 1993 Psychol. Rev. 100 , 363–406) seminal study on deliberate practice. Ericsson et al . found that differences in retrospective estimates of accumulated amounts of deliberate practice corresponded to each skill level of student violinists. They concluded, ‘individual differences in ultimate performance can largely be accounted for by differential amounts of past and current levels of practice’ (p. 392). We reproduced the methodology with notable exceptions, namely (i) employing a double-blind proce
View details →Mingshu Wang, Neil Debbage · 2021 · Computers Environment and Urban Systems
Traffic congestion is an ever-increasing issue across urban environments in the US. One potential mitigation strategy is to improve our understanding of how the geographical patterns of urban land use influence congestion. Unfortunately, there is no consensus regarding if more sprawling or dense urban morphologies help mitigate congestion issues. To potentially clarify the conflicting findings of previous studies, we used a detailed spatial metric-based approach and panel regression to quantify the relationships between urban development patterns and congestion in 98 US urban areas from 2001 t
View details →Bertha Briceño, Aidan Coville, Paul Gertler et al. · 2017 · PLoS ONE
SUMMARY: The current evidence on handwashing and sanitation programs suggests limited impacts on health when at-scale interventions have been tested in isolation. However, no published experimental evidence currently exists that tests the interaction effects between sanitation and handwashing. We present the results of two large-scale, government-led handwashing and sanitation promotion campaigns in rural Tanzania, with the objective of tracing the causal chain from hygiene and sanitation promotion to changes in child health outcomes and specifically testing for potential interaction effects o
View details →Ahmed M. Elkhatat · 2023 · International Journal for Educational Integrity
Abstract Academic plagiarism is a pressing concern in educational institutions. With the emergence of artificial intelligence (AI) chatbots, like ChatGPT, potential risks related to cheating and plagiarism have increased. This study aims to investigate the authenticity capabilities of ChatGPT models 3.5 and 4 in generating novel, coherent, and accurate responses that evade detection by text-matching software. The repeatability and reproducibility of both models were analyzed, showing that the generation of responses remains consistent. However, a two-sample t-test revealed insufficient evidenc
View details →Boris Worm, Sara Orofino, Echelle S. Burns et al. · 2024 · Science
Over the past two decades, sharks have been increasingly recognized among the world's most threatened wildlife and hence have received heightened scientific and regulatory scrutiny. Yet, the effect of protective regulations on shark…
View details →Sheng‐Kai Wu, Marc A. Santos, Stuart L. Marcus et al. · 2019 · Scientific Reports
Abstract Glioblastoma multiforme (GBM) continues to have a dismal prognosis and significant efforts are being made to develop more effective treatment methods. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. It has long been known that ultrasound exposure can cause both thermal and non-thermal bioeffects and it remains an open question to what degree does temperature impact the efficacy of SDT. In order to optimize the ultrasound parameters of SDT, transcranial MRI-guided focused ultr
View details →Julian Gold, Raph Goldacre, H Maruszak et al. · 2014 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: Even though multiple sclerosis (MS) and HIV infection are well-documented conditions in clinical medicine, there is only a single case report of a patient with MS and HIV treated with HIV antiretroviral therapies. In this…
View details →Nancy Kass, Holly A. Taylor, Joseph Ali et al. · 2014 · Clinical Trials
BACKGROUND: Research suggests that participants do not always adequately understand studies. While some consent interventions increase understanding, methodologic challenges have been raised in studying consent outside of actual trial…
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