Negative / Null Result ReportMedicine
Inamura Y, Miyazaki S, Nitta J et al. · 2026 · Heart rhythm
Background A size-adjustable cryoballoon (SACB, POLARxFIT, Boston Scientific), switching between 28-mm and 31-mm diameters, was introduced for atrial fibrillation ablation; however, its efficacy and safety compared with conventional…
View details →Negative / Null Result Report
Chusyd DE, Austad SN, Brown JL et al. · 2026 · Preprint
Early-life trauma in humans, including maternal loss, is strongly associated with increased risk of chronic diseases, reduced life expectancy, and accelerated biological aging, as measured through epigenetic modifications, such as DNA…
View details →Replication FailureMedicine
Neeser HR, Gerwinn T, Forschbach VC et al. · 2026 · Journal of pediatric surgery
Background Children still suffer from substantial pain after laparoscopic surgery. It has been hypothesized that low-pressure pneumoperitoneum reduces postoperative pain after laparoscopic surgery. However, this has not yet been studied in…
View details →Replication FailureMedicine
Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons
Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…
View details →Negative / Null Result ReportMedicine
Adami A, Vitacca M, Casaburi R et al. · 2026 · European journal of applied physiology
PURPOSE: Long-term oxygen therapy (LTOT) is an established treatment for patients with chronic obstructive pulmonary disease (COPD) diagnosed with hypoxemia at rest or during activity. Chronic hypoxemia is a potential mediator of loss of…
View details →Negative / Null Result Report
Lorrimar V, van Mulukom V · 2025 · Preprint
In an era of polycrisis, the philosophy of longtermism posits that positively influencing the long-term future is a key moral priority. This study investigates psychological factors predicting moral concern for future generations, focusing…
View details →Negative / Null Result ReportOpen accessMedicine
Le Blanc-Brillon J, Fortin JS, Lafrance L et al. · 2025 · Frontiers in psychology
Introduction Social networking sites (SNSs) have become an integral part of daily life, raising concerns about their potential impact on mental health. One key mechanism through which SNSs may affect wellbeing is social comparison. The…
View details →Negative / Null Result ReportMedicine
Smulligan KL, Lempke LB, Mannix RC et al. · 2026 · The Journal of pediatrics
Objective To investigate whether slower reaction time (RT) was associated with higher concussion odds among middle school female soccer players. Study design We performed a retrospective cohort study, analyzing pre-participation…
View details →Negative / Null Result Report
De Laet H, Nijhof A, Wiersema JR · 2025 · Preprint
Purpose: Autism is associated with social interaction and communication difficulties. The theory of the double empathy problem challenges the idea that these difficulties are inherent to autism, arguing that they rather stem from a…
View details →Failed Experiment Report
Wu R, Jin H, Shen J · 2025 · Preprint
Abstract Despite known benefits in normal diet, capsaicin's effects under obesogenic conditions remain unexplored. Based on capsaicin's established metabolic benefits, we hypothesized that capsaicin supplementation would extend lifespan in…
View details →Failed Experiment ReportMedicine
Clucas K, Saito A · 2026 · The Physician and sportsmedicine
Background Medial elbow injuries occur in approximately one-third of all young baseball players and are characterized by injuries to the bone and cartilaginous growth plates. Bone mineral mass, a representative of bone strength, may show…
View details →Failed Experiment ReportMedicine
Adams R, Deroche MLD · 2025 · The Journal of the Acoustical Society of America
To extract a voice from a background of competing speakers, the human brain exploits voice pitch (harmonic cues) and spatial location (binaural cues) to separate speakers perceptually, and effectively attenuates the background (anything…
View details →Failed Experiment ReportOpen accessMedicine
LeBlanc MR, Zhou X, Baggett CD et al. · 2026 · Cancer medicine
Background This study aims to describe time to treatment initiation for Black and White older adults with multiple myeloma (MM), and to test the hypothesis that Black/White disparities in treatment initiation have increased over time.…
View details →Failed Experiment ReportMedicine
Ogawa K, Shimatani K, Endo K et al. · 2026 · Public health
Objectives This study examined the association between individual housing cost burden and depressive symptoms, hypothesizing stronger associations particularly in primary breadwinner men who may bear disproportionate financial…
View details →Failed Experiment Report
Ruan N, Ng AJ, Christianson JP · 2025 · Preprint
ABSTRACT Competing motivational drives are integral to survival and encompass a spectrum of internal physiological needs such as hunger to external goals like social connection. Elucidating how these motivational states interact at the…
View details →Failed Experiment ReportMedicine
Song J, Pennartz KJ, Caldwell JT et al. · 2026 · European journal of applied physiology
Purpose Near-infrared spectroscopy (NIRS) with vascular occlusion testing (VOT) is used to assess skeletal muscle tissue oxygenation (StO 2 ) responses. Differences in NIRS-VOT outcomes exist between trained and untrained groups; however,…
View details →Negative / Null Result Report
Chung YH, Williams L, Brady TF et al. · 2025 · Preprint
Across many studies, verbal labels have been shown to significantly affect perceptual and cognitive processes. Here we ask whether verbal labels can also improve visual working memory performance by making objects more recognizable. In a…
View details →Negative / Null Result ReportMedicine
Weerakoon SM, Henson-Garcia M, Rose R et al. · 2025 · Community health equity research & policy
BackgroundBlack and Latinx youth are disproportionately exposed to neighborhood violence and related mental health challenges. Racial-ethnic identity shapes how adolescents perceive, interpret, and cope with stressful environmental…
View details →Negative / Null Result ReportMedicine
van Witteloostuijn M, Blom E · 2025 · Journal of communication disorders
Multilingual children naturally encounter language mixing in their environment. Since children's language development depends on their language input, and processing language mixing in the input may be cognitively demanding, the amount of…
View details →Negative / Null Result ReportMedicine
Pizzolla E, Fiorio M, Marotta A et al. · 2026 · Quarterly journal of experimental psychology (2006)
Fatigue has a profound impact on various sensory and perceptual processes; yet, its effects differ depending on whether it arises from physical or mental exertion. While physical fatigue is known to alter body weight perception, it remains…
View details →Negative / Null Result ReportOpen accessMedicine
Traylor DA, Nunes EA, Lees MJ et al. · 2026 · Health science reports
Background and aim Testosterone is an important hormone in male physiology, playing a key role in reproductive function, muscle growth, bone mineral density, and metabolic regulation. Cold exposure is celebrated in fitness and wellness…
View details →Negative / Null Result ReportMedicine
Ye J, Huang Y, Liu X et al. · 2025 · Biochemical and biophysical research communications
Schisandrin B (SchB), a natural lignan with reported organ-protective effects, was hypothesized to ameliorate severe acute pancreatitis (SAP). We investigated the effects of SchB (30 and 60 mg/kg) in a caerulein-induced mouse model of SAP…
View details →Negative / Null Result ReportOpen accessMedicine
Magura T, Mizser S, Horváth R et al. · 2026 · Insects
Urbanization is a major and rapidly expanding form of land-use change worldwide and is one of the main drivers of the decline in arthropod diversity. Within urban matrices, remnants of natural or semi-natural habitats serve as important…
View details →Negative / Null Result Report
Thorudottir S, Asgeirsson AG, Sigurdardottir HM · 2025 · Preprint
Visual mental imagery, or the ability to “see” with the mind’s eye, varies substantially across individuals. This vividness ranges from aphantasia, where no mental images are experienced, to hyperphantasia, characterized by exceptionally…
View details →Negative / Null Result ReportMedicine
Frish Simcovich Y, Eigner E, Joskowicz L et al. · 2026 · The Journal of hand surgery, European volume
We examined the correlations between the surface morphology of acute scaphoid fractures and their stability. Our hypothesis was that a more irregular fracture surface would have a stabilizing effect on the fracture. A total of 75 isolated…
View details →Negative / Null Result ReportMedicine
Li YC, Lemaire KK, Bruijn SM et al. · 2025 · Neuroscience
Walking without falling requires correcting the deviations of the centre of mass (CoM) trajectory relative to the base of support. This process is partially under feedback control. We investigated whether vestibular afference contributes…
View details →Negative / Null Result Report
Gautier R, Latinus M, Briend F · 2025 · Preprint
The Heartbeat Evoked Potential (HEP) is a potential marker of cardiac signal integration at the cerebral level, obtained by averaging epochs time-locked to the ECG R-peaks. The HEP is modulated across different experimental conditions with…
View details →Negative / Null Result ReportMedicine
Hascher K, Brown R, Janulis P et al. · 2026 · Biopsychosocial science and medicine
Objective Sexual minority (SM) populations experience worse cardiovascular health than heterosexual populations. One potential pathway is the effects of disclosure (sharing) or concealment (withholding) of SM identity due to anticipated…
View details →Negative / Null Result ReportOpen accessMedicine
Kweon J, Ganesh P, Brown JC · 2025 · Transcranial magnetic stimulation (2024)
Health and behavioral factors likely influence repetitive transcranial magnetic stimulation (rTMS) effectiveness, though clear support is lacking. Since habitual caffeine use has been found to impair corticomotor plasticity, we…
View details →Negative / Null Result ReportMedicine
Chung YH, Williams LH, Brady TF et al. · 2025 · Journal of experimental psychology. General
Across many studies, verbal labels have been shown to significantly affect perceptual and cognitive processes. Here, we ask whether verbal labels can also improve visual working memory performance by making objects more recognizable. In a…
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