21,742 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bremhorst A, Mills DS, Würbel H et al. · 2022 · Animal cognition
Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System…
View details →Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…
View details →Bedlack R, Barkhaus P, Carter G et al. · 2022 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit.…
View details →Aouad K, El-Zorkany B · 2022 · Mediterranean journal of rheumatology
The Treat-to-target (T2T) strategy in axial spondyloarthritis (axSpA) stipulates that treatment should reach a predefined target and if not reached, intensification of therapy is implemented aiming at best future outcomes. Clinical…
View details →Turvill J, Haritakis M, Pygall S et al. · 2026 · Endoscopy international open
Background and study aims During the COVID-19 pandemic the National Health Service introduced colon capsule endoscopy (CCE) as an alternative to colonoscopy in patients awaiting 3-year post-polypectomy surveillance. We determined the…
View details →Pepine CJ, Handberg E, Cooper-DeHoff R et al. · 2026 · Open heart
Importance Women with angina due to suspected ischaemia referred for coronary angiography often have no obstructive coronary artery disease (ANOCA/INOCA). Objective To determine if intensive medical treatment (IMT) reduces major ischaemic…
View details →Wessels AM, Edgar CJ, Nathan PJ et al. · 2021 · Drug discovery today
Go/No-Go decision making in early phase clinical trials is challenging for drug developers working in Alzheimer's disease. Recent negative trial results have been attributed to a lack of efficacy and important safety concerns. Furthermore,…
View details →Chalak LF, Kang S, Kota S et al. · 2023 · Early human development
Background There is a critical need for development of physiological biomarkers in infants with birth asphyxia to identify the physiologic response to therapies in real time. This is an ancillary single site study of the High-Dose…
View details →Mudugal D, Monteith TS · 2021 · Expert review of neurotherapeutics
Introduction : Cluster headache [CH] is a severely disabling trigeminal autonomic cephalalgia [TAC]. Approximately 1 in 1,000 adults are affected by CH. Calcitonin gene-related peptide [CGRP] is an important mediator in the pathophysiology…
View details →Figueroa-Parra G, Putman MS, Crowson CS et al. · 2024 · Lupus science & medicine
Objective We aimed to evaluate the robustness of phase III randomised controlled trials (RCTs) for SLE and lupus nephritis (LN) using the fragility index (FI), the reverse FI (RFI) and the fragility quotient (FQ). Methods We searched for…
View details →Li S, Mahr C, Kataria R et al. · 2026 · JACC. Advances
Background Landmark randomized controlled trials like DanGer Shock, IABP-SHOCK II, and ECLS-SHOCK guide infarct-related cardiogenic shock (CS) management with temporary mechanical circulatory support (tMCS), but strict enrollment criteria…
View details →Albers GW, Bernstein R, Brachmann J et al. · 2021 · Stroke
Occult atrial fibrillation (AF) is a leading cause of stroke of unclear cause. The optimal approach to secondary stroke prevention for these patients remains elusive. The term embolic stroke of undetermined source (ESUS) was coined to…
View details →Ishizuka K, Ono S · 2025 · Journal of clinical pharmacology
Despite the tremendous effort in the oncology community, the success rate of anticancer development remained low at 30% to 40% from the Phase 3 study to the regulatory approval. The factors associated with the regulatory approval for…
View details →Chen H, Colasurdo M, Matsukawa H et al. · 2026 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →Cerbone L, Orecchia S, Bertino P et al. · 2023 · Cancers
Mesothelioma comprises a group of rare cancers arising from the mesothelium of the pleura, peritoneum, tunica vaginalis testis and pericardium. Mesothelioma is generally associated with asbestos exposure and has a dismal prognosis, with…
View details →Pope JE · 2020 · The Lancet. Rheumatology
Strides have been made in the treatment of pulmonary arterial hypertension and interstitial lung disease in patients with systemic sclerosis, with successful trials of combination therapies in pulmonary arterial hypertension and of new…
View details →Persu A, Stoenoiu MS, Maes F et al. · 2023 · Clinical kidney journal
Following second-generation randomized trials, there is evidence that renal denervation (RDN) decreases blood pressure (BP), although to a lesser extent than suggested in the initial controlled and observational studies. The recent…
View details →Azarbarzin A, Vena D, Esmaeili N et al. · 2026 · European heart journal
Background and aims Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and…
View details →de Zeeuw D · 2020 · Journal of nephrology
Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will…
View details →Georgiadis AG, Schavee PE, Koester TM et al. · 2025 · JB & JS open access
Background Cast removal may produce pain or anxiety in children. Virtual reality (VR) has been studied in other pediatric settings, but little evidence exists for its use during pediatric cast removal. Methods A randomized controlled trial…
View details →Bromberg JEC, Issa S, van der Holt B et al. · 2024 · Neuro-oncology
Background Studies on the efficacy of rituximab in primary CNS lymphoma (PCNSL) reported conflicting results. Our international randomized phase 3 study showed that the addition of rituximab to high-dose methotrexate, BCNU, teniposide, and…
View details →Pellesi L, Onan D, Martelletti P · 2024 · Toxins
Post-traumatic headache (PTH) is a common and debilitating consequence of traumatic brain injury (TBI), often resembling migraine and tension-type headaches. Despite its prevalence, the optimal treatment for PTH remains unclear, with…
View details →Zhou Q, Gao B, Hu J et al. · 2026 · BMJ oncology
Background Many patients with non-small cell lung cancer (NSCLC) have tumours that are either refractory or develop resistance following an initial response to anti-programmed cell death protein (ligand)-1 (PD-(L)1)-based treatment,…
View details →Kasperkiewicz M, van Beek N, Schmidt E · 2026 · Drugs
Autoimmune blistering diseases (AIBDs) are a heterogeneous group of at least a dozen disorders characterized by autoantibodies against structural proteins of desmosomes in the skin and surface-close epithelia in pemphigus and of the…
View details →Baugher B, Walter E, Hennigs E et al. · 2025 · Cureus
Freezing of gait (FoG) is a disabling symptom of Parkinson's disease (PD) characterized by involuntary cessation/reduction. While deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) effectively treats common PD symptoms…
View details →Gomeni R, Hopkins S, Bressolle-Gomeni F et al. · 2023 · Translational psychiatry
The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in depressive disorders. The conventional study designs,…
View details →Park L, Furey M, Nugent A et al. · 2018 · Biological psychiatry
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This conference abstract has been retracted at the request of author Maura Furey,…
View details →Autler AS, Darling AM, Skow RJ et al. · 2025 · Autonomic neuroscience : basic & clinical
Young women, who suffer from major depressive disorder (MDD) at twice the rate as young men, are particularly vulnerable to cardiovascular events triggered by emotional stress, an association that may be partially explained by excessive…
View details →Molto A, López-Medina C, Van den Bosch FE et al. · 2021 · Annals of the rheumatic diseases
Objectives To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those of usual care (UC). Methods Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial…
View details →Denton CP, Del Galdo F, Khanna D et al. · 2022 · Rheumatology (Oxford, England)
Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process.…
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