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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Clinical real-world data evaluation: comparison of central macular thickness after anti-VEGF treatment in diabetic macular edema patients treated with or without topical anti-glaucoma agents.

Baybora H, Özal E, Özal SA · 2026 · BMC ophthalmology

Background There are research findings suggesting that antiglaucoma agents may reduce aqueous humor outflow and decrease the elimination of intravitreally administered anti-vascular endothelial growth factor agents, prolonging their…

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Negative / Null Result ReportOpen accessMedicine

Mid-Term Oncological Outcomes of Vaginal Natural Orifice Transluminal Endoscopic Surgery Compared with Total Laparoscopic Hysterectomy for Early-Stage Endometrial Cancer: A Single-Center Retrospective Study.

Imai K, Abe J, Chikazawa K et al. · 2026 · Journal of clinical medicine

Background/Objectives : Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is increasingly being used to avoid abdominal incisions; however, its mid-term oncological safety in endometrial cancer remains unclear. Methods :…

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Negative / Null Result ReportOpen accessMedicine

Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial.

Thanawala S, Shah R, Alluri KV et al. · 2026 · Medicine

Background The adaptogenic effects of Ashwagandha root extract are evident. An earlier study showed the therapeutic effects of a once-daily sustained-release (SR) formulation (300 mg) of Ashwagandha root extract over an extended period.…

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Negative / Null Result ReportOpen accessMedicine

Assessing the effect of deficit irrigation and biochar application on soil water depletion, root distribution, and water productivity of cucumber in semi-arid West Texas.

Kafle A, Singh S, Singh M et al. · 2026 · Frontiers in plant science

Understanding crop root growth and distribution and soil water depletion under water deficit conditions is critical for developing sustainable production practices for cucumber ( Cucumis sativus L.) in semi-arid regions like West Texas.…

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Negative / Null Result ReportMedicine

CT-Based Blood Burden Scores for Predicting Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage: A Comparative Analysis of Quantitative and Qualitative Scoring Systems.

Sarkis H, Kerhani AA, Hedderich DM et al. · 2026 · World neurosurgery

Background/objective Shunt-dependent hydrocephalus represents a major complication of aneurysmal subarachnoid hemorrhage (aSAH), yet no universally adopted CT-based prediction tool exists. Fisher-based scales suffer from a ceiling effect…

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Negative / Null Result ReportMedicine

Surface roughness and surface microhardness of bulk-fill and conventional resin composites after erosive-abrasive cycles: A laboratory study.

Devletli Ozygit L, Eyuboglu GB · 2026 · American journal of dentistry

Purpose To investigate comparatively the changes in surface roughness and surface microhardness of resin composites applied with traditional incremental layering technique and bulk-fill resin composites after erosive/abrasive applications.…

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Negative / Null Result ReportOpen accessMedicine

Effects of load carriage methods on fall risk and gait variability during stair ascent: a functional data analysis approach.

Zhang X, Li Y, Fang Y et al. · 2026 · Frontiers in bioengineering and biotechnology

Objective Based on the existing research that predominantly focuses on loaded level walking or employs discrete-point methods to analyze stair negotiation, this study utilizes functional data analysis to systematically investigate the…

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Negative / Null Result ReportMedicine

Comparison of decentration, tilt, and dynamic stability between retropupillary iris claw and scleral fixated intraocular lenses with flanged haptics.

Zeilinger J, Regitnig P, Kronschläger M et al. · 2026 · Journal of cataract and refractive surgery

Purpose To compare decentration, tilt, and dynamic stability ("wobble") between retropupillary fixated iris claw intraocular lenses (IOL) and double needle flanged scleral fixated technique. Setting Vienna Institute for Research in Ocular…

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Negative / Null Result ReportOpen accessMedicine

Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study.

Gu XY, Cao JF, Zhang XY et al. · 2026 · Drug design, development and therapy

Objective This trial aimed to compare the effects of alfentanil and sufentanil on postoperative nausea and vomiting (PONV) in patients at moderate-to-high risk undergoing sedated gastrointestinal endoscopy. Methods Two hundred and eighteen…

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Negative / Null Result ReportOpen accessMedicine

Morphometrıc evaluatıon of patıents wıth mandıbular hypomobılıty due to coronoıd process hyperplasıa usıng cone beam computed tomography.

Kurt Akgül Ş, Boylu ÖF · 2026 · Surgical and radiologic anatomy : SRA

PURPOSE: Mandibular hypomobility is a condition in which the jaw joint is restricted due to various causes, including temporomandibular joint disorders (TMD), ankylosis, head and neck infections and tumors, coronoid processes hyperplasia…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of multiple freeze-thaw cycles on growth factor and cytokine stability in canine platelet lysate: PDGF, TGF-<i>β</i>, and TNF-<i>α</i> preservation across cycles.

Sumner SM, Naskou MC · 2026 · Frontiers in veterinary science

Introduction Platelet-rich plasma (PRP) and platelet lysate (PL) are biologically active products used in regenerative medicine because of their high concentrations of growth factors, cytokines, and other bioactive molecules that promote…

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Negative / Null Result ReportMedicine

Observation on the clinical effects of four kinds of root canal filling materials in the treatment of chronic periapical periodontitis.

Wang K, Chen Y, Fu H et al. · 2026 · American journal of translational research

Objective To compare the clinical efficacy of four root canal filling materials for the treatment of chronic periapical periodontitis. Methods The clinical data of 200 patients with chronic periapical periodontitis from January 2023 to…

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Negative / Null Result ReportMedicine

Residual gastric content after holding of glucagon-like peptide-1 receptor agonists before elective surgery: a cross-sectional study - the RESIDUAL study.

Boudreau C, Couture M, Rousseau-Saine N et al. · 2026 · BMC anesthesiology

Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are now increasingly used for glycemic control in type 2 diabetes mellitus as well as for weight loss. Their effect on gastric emptying may increase the risk of aspiration…

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Negative / Null Result ReportMedicine

Desflurane versus sevoflurane and postoperative inflammatory biomarkers in older adults undergoing minor- to moderate-risk noncardiac surgery.

Adamowitsch N, Reiterer C, Fleischmann E et al. · 2026 · Scientific reports

Volatile anesthetics modulate inflammatory responses, but it remains unclear whether desflurane and sevoflurane differ in their effects on postoperative inflammation. We evaluated in this secondary analysis of a prospective randomized…

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Negative / Null Result ReportOpen accessMedicine

Maternal vaginal colonization screening for term singleton pregnancy: comparative evaluation of metagenomic next-generation sequencing (mNGS) versus real-time quantitative PCR (qPCR).

Zhang J, Liang J, Lv F et al. · 2026 · Practical laboratory medicine

Objective To investigate the distribution characteristics of potential high-risk pathogens for early-onset neonatal infection in maternal vaginal secretions, and to perform a head-to-head comparative evaluation of detection performance for…

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