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Browse the failure-mode index

21,283 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The Effect of a Series of Lower Limb Pressotherapy Treatments on the Range of Motion of the Lower Limb Joints, Lower Limb Circumferences, and Body Composition in Young, Healthy Women.

Ptaszek B, Kurek O, Podsiadło S · 2026 · Lymphatic research and biology

Purpose In times when health and physical activity are gaining in value, the search for effective methods to support fitness and improve quality of life is becoming a priority. One of the therapies that is gaining increasing popularity is…

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Negative / Null Result ReportMedicine

Anthropometric differences between twins at birth and their association with later cognitive performance.

Eves R, Deppe M, Kandler C et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background Past studies indicate significant associations between birth anthropometrics, such as relative birthweight or head circumference, and later cognitive performance. Using twin data, we investigated whether these associations are…

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Negative / Null Result ReportMedicine

Prognostic dynamics of pathological complete response and ctDNA clearance after neoadjuvant/perioperative immunotherapy in cancer: a reconstructed individual patient analysis.

Garitaonaindia Y, Witteveen S, Dionisio E et al. · 2026 · Journal of the National Cancer Institute

Background Pathological complete response (pCR) and circulating tumor DNA (ctDNA) clearance are increasingly used as intermediate endpoints in neoadjuvant and perioperative immunotherapy (IO) trials. However, whether complete pathological…

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Negative / Null Result ReportOpen accessMedicine

Admission Physiology Appeared More Informative Than Small-for-Gestational-Age Status for Predicting Severe In-Hospital Disposition in Preterm Infants Born at 28-36 Weeks: A Retrospective Single-Center NICU Cohort Study.

Ghorooneh Z, Mohammadzadeh A, Farhat AS et al. · 2026 · BMC pediatrics

BACKGROUND: Whether small for gestational age adds prognostic information after NICU admission physiology is known remains uncertain in preterm infants. This distinction is clinically important because SGA is an anthropometric birth-size…

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Negative / Null Result ReportMedicine

Substantial Operative and Nonoperative Mortality Persists in Neonatal Ebstein Anomaly: A 20-Year Multi-Institutional Analysis.

Turner D, Mehdizadeh-Shrifi A, Faateh M et al. · 2026 · World journal for pediatric & congenital heart surgery

BackgroundWe sought to characterize the epidemiology, treatment patterns, and outcomes of neonatal Ebstein anomaly using a national database.MethodsIn this descriptive analysis, the pediatric health information system (PHIS) database was…

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Negative / Null Result ReportMedicine

Magnetic Resonance Imaging-Based Psoas Muscle Volume as an Additional Risk Factor for Fontan Failure: A Prospective Cohort Study.

Erdem S, Hussain T, Erdem O et al. · 2026 · Journal of the American Heart Association

Background Sarcopenia is prevalent in patients with Fontan circulation and may contribute to functional decline and adverse outcomes. It is commonly assessed using the cross-sectional area of the psoas muscle (PMA), although volumetric…

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Negative / Null Result ReportMedicine

Intrathecal antibody synthesis - Reiber method revisited.

Halperin JJ, Granger D · 2026 · BMC neurology

Background CSF immunoglobulin (IgG) often informs diagnosis in CNS inflammatory disease- qualitatively (oligoclonal bands; OCBs), or quantitatively (CSF: serum IgG: albumin, e.g. IgG index). Most US laboratories estimate excess CSF IgG…

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Negative / Null Result ReportOpen accessMedicine

Risk Stratification of Adverse Outcomes After Heart Transplantation with the 2022 Definition of Pulmonary Hypertension.

Corianò M, Pradegan N, Putortì F et al. · 2026 · Journal of cardiovascular development and disease

Pulmonary hypertension (PH) is associated with adverse outcomes after heart transplantation (HT). In 2022, the European Society of Cardiology introduced lower thresholds for pulmonary vascular resistance (PVR) to distinguish isolated…

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Negative / Null Result ReportMedicine

Quality assessment of radiographs through AI-driven feedback: A randomized comparative study on radiographer response in lateral knee radiographs.

Lysdahlgaard S, Jensen J, Pedersen MRV et al. · 2026 · Radiography (London, England : 1995)

Introduction High-quality radiographic positioning is essential for accurate diagnosis in knee imaging. Although artificial intelligence (AI) can assess image quality with high accuracy, its influence on radiographers' clinical…

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Negative / Null Result ReportMedicine

Retrospective Comparative Analysis of Diffusion Tensor and Constrained Spherical Deconvolution Tractography Models in a Clinical Neurosurgical Navigation Platform.

Watanabe A, Furukawa M, Hiruta R et al. · 2026 · Neurologia medico-chirurgica

Tractography is a technique for visualizing the trajectories of white matter pathways. The most widely used model, the diffusion tensor imaging, assumes a single fiber orientation within each voxel. In contrast, the constrained spherical…

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Negative / Null Result ReportMedicine

Enzalutamide Plus Metformin Versus Enzalutamide Alone in Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 2 Trial (SAKK 08/14).

Gillessen S, Gobat K, Cathomas R et al. · 2026 · European urology oncology

Background and objective The aim of our study is to determine whether the addition of metformin to enzalutamide can improve the outcomes of men with metastatic castration-resistant prostate cancer (mCRPC). Methods From 2016 to 2021,…

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Negative / Null Result ReportMedicine

Modulation of neuroendocrine and autonomic responses to competitive stress by slow cortical potentials training in golfers: An exploratory randomized controlled trial.

Lizama E, Carcamo-Herrera B, López G et al. · 2026 · Psychoneuroendocrinology

Performance in precision sports such as golf depends on the athlete's ability to regulate psychophysiological responses under competitive pressure. Heart rate variability (HRV), cortisol, and DHEA provide complementary indices of autonomic…

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Negative / Null Result ReportOpen accessMedicine

Gene-specific response to muscle specific kinase agonist antibody in the treatment of congenital myasthenic syndromes.

Ho K, Adjei-Afriyie O, Carmona-Martinez R et al. · 2026 · Brain communications

Congenital myasthenic syndromes (CMS) are a group of rare disorders characterized by fatigable muscle weakness and caused by impaired neuromuscular junction (NMJ) function. CMS symptoms are highly variable, but it can be detrimental and…

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Negative / Null Result ReportMedicine

[Anti-leucine-rich glioma-inactivated 1 antibody-positive encephalitis with a poor response to corticosteroids 2 months after onset of impaired memory: a case report].

Araga Y, Nakamura Y, Sugita C et al. · 2026 · Rinsho shinkeigaku = Clinical neurology

The patient was a 30-year-old man who was admitted to our department 2 months after the onset of anterograde amnesia. Cognitive function tests indicated memory impairment only. MRI FLAIR images of the head showed a high signal in the…

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Negative / Null Result ReportMedicine

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Pham TN, Chamseddine I, Lebhertz D et al. · 2026 · Physics in medicine and biology

Introduction. Radiation-induced optic neuropathy (RION) is a rare but functionally-disabling complication of radiotherapy for brain and head/neck tumors. Even with modern proton therapy and adherence to dose constraints, about 6% of…

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Negative / Null Result ReportMedicine

Comparative performance of one-stage and two-stage deep learning models for instance segmentation of overhanging dental restorations on bitewing radiographs.

Hatipoğlu Ö, Başar Ö, Mağat G et al. · 2026 · Scientific reports

Accurate detection of overhanging dental restorations on bitewing radiographs is clinically important but remains challenging due to subtle marginal discrepancies. This study aimed to develop and compare deep learning-based instance…

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