21,266 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Al Saeedi M, Abdurakhimova DA, Arabi T et al. · 2026 · Radiology
Background Renal artery stenosis (RAS) can trigger the development of renal damage and poststenotic dilatation (PSD). However, the clinical relevance and mechanisms are ill-characterized. Purpose To characterize the mechanisms underlying…
View details →Hwang S, Kim PH, Kim H et al. · 2026 · Journal of neuro-oncology
Purpose Selumetinib is approved for the treatment of inoperable plexiform neurofibromas (PN) in patients with neurofibromatosis type 1 (NF1). However, its efficacy in treating NF1-associated diffuse neurofibromas (NF1-DN) or optic pathway…
View details →Vuaran E, Trunfio M, Russo M et al. · 2026 · Journal of neurovirology
INTRODUCTION: Blood biomarkers would be the ideal tool in routine practice in early identifying People With HIV (PWH) with low cognitive performance (LNP). We aimed to assess the diagnostic performance of neurodegeneration and brain injury…
View details →Le Thi TG, Geist M, Novosad Y et al. · 2026 · European journal of preventive cardiology
Aims This overview of systematic reviews (SRs) summarizes evidence on effectiveness and safety of treatment for paediatric heterozygous familial hypercholesterolaemia (heFH) and multifactorial dyslipidaemia (MFD). Methods and results…
View details →Heidari Z, Gharibi G, Alaeen H et al. · 2026 · Journal of pineal research
This study aimed to evaluate the effects of melatonin supplementation on disease severity, sleep quality, and quality of life in adult patients with atopic dermatitis (AD). This study was designed as a randomized, double-blind,…
View details →Das T, Belenje A, Joseph J et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose Report the clinico-microbiological characteristics of multidrug-resistant acute postcataract bacterial endophthalmitis. Methods Consecutive 32 cases from a prospective multicenter study in India were analyzed for the clinical…
View details →Gabrielsen R, Tellum T, Bø K et al. · 2025 · Journal of physiotherapy
Question How much does adding supervised group and independent individual exercise including pelvic floor muscle training (PFMT) to multidisciplinary pain management affect pelvic and genital pain in women with endometriosis? How much does…
View details →Redman N, Brumbaugh K, Farquharson K · 2025 · Seminars in speech and language
This investigation compared the effectiveness of the Cycles Approach with and without auditory stimulation. Using an alternating treatment design (AATD), three preschool-aged children with severe phonological disorders received a modified…
View details →Li X, Yan M, Li T et al. · 2025 · Preprint
Abstract Background Perineural invasion (PNI), though reported with varying incidence in rectal cancer, is a recognized marker of adverse prognosis. While postoperative adjuvant radiotherapy is a cornerstone of multidisciplinary management…
View details →Minkley M, Ravasia K, Nghiem T et al. · 2026 · Virchows Archiv : an international journal of pathology
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an aggressive and molecularly heterogenous cancer with poorly defined treatment strategies. We aimed to (i) assess whether RB1 immunohistochemistry alone can prognostically stratify…
View details →Kakihara S, Busza AM, Duffy BV et al. · 2026 · American journal of ophthalmology
Objective To determine whether foveal avascular zone (FAZ) enlargement and geometric perfusion deficits in the deep capillary plexus (GPDd) are independently associated with retinal nonperfusion in different regions of ultrawidefield…
View details →Bansaghi S, Klein J · 2026 · Preprint
Background Cruise ships are relatively small, crowded spaces where many people travel in a new environment, making infection control especially important. Proper hand hygiene is the first line of defense against the spread of infection.…
View details →Kuula L, Pesonen AK · 2026 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine
Purpose Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we…
View details →Silva LEV, Balcarcel D, Ko TS et al. · 2026 · Resuscitation
Aims Heart rate variability (HRV), a non-invasive measure of autonomic function, may offer prognostic value after pediatric cardiac arrest. We used machine learning models to determine whether HRV features within the first 24 h after…
View details →Miao Y, Zhang H, Wu J et al. · 2026 · Journal of clinical anesthesia
Background Clinical evidence on obturator nerve involvement after supra-inguinal fascia iliaca compartment block (SFICB) is limited. This study aimed to investigate whether a 40-mL SFICB reliably anesthetizes the obturator nerve and…
View details →Aitken D, Cai G, Hill CL et al. · 2026 · JAMA internal medicine
Importance Knee osteoarthritis (OA) is disabling, with few effective treatments. Anti-inflammatory treatments may be effective for patients with an inflammatory phenotype. Objectives To evaluate the efficacy of the interleukin-1β blocker…
View details →Bori-Bru B, Salvador JP, Crehuet R · 2025 · Preprint
Generative models have advanced profusely in recent years, generating great impact in computational modelling and structural bioinformatics. A part of computational protein design focuses on antibody and nanobody engineering, targeting…
View details →Najjar-Debbiny R, Cohen R, Arbel A et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
BACKGROUND: Mycobacterium simiae is an emerging cause of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the Middle East, yet treatment outcomes remain unclear. We aimed to evaluate clinical and microbiologic outcomes of M.…
View details →Rhyu KH, Cho YJ, Chun YS et al. · 2026 · Clinical orthopaedics and related research
Background Cementing a new liner into a well-fixed acetabular cup with a deficient locking mechanism has been reported as a viable option, but concerns remain regarding complications such as dislocation and late loosening.…
View details →Morales AA, Camarena V, Peart L et al. · 2025 · Preprint
Abstract Geleophysic dysplasia (GD) is a rare genetic disorder characterized by short stature, joint contractures, and cardiopulmonary complications, with early mortality, and linked to mutations in ADAMTSL2 (GD1), FBN1 (GD2), or LTBP3…
View details →Fatima H, Schaffert J, Carlew AR et al. · 2025 · The Clinical neuropsychologist
Objective Cognitive dispersion (CD) or neuropsychological test score variability has been associated with more rapid cognitive decline, and the development of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The predictive…
View details →Agyeman AA, Buggiotti L, Brown LK et al. · 2026 · British journal of clinical pharmacology
Aims The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it…
View details →Khoshnevis A, Zayernouri M, Malete L et al. · 2026 · Journal of voice : official journal of the Voice Foundation
Objective Voice-based biomarkers have been proposed as objective tools for anxiety assessment, yet existing research relies on small, demographically homogeneous samples and shows inconsistent associations between fundamental frequency (F…
View details →Kwon Y, Park J, Kim D et al. · 2026 · Obesity surgery
Background While bariatric surgery (BS) is an effective treatment for gout in patients with morbid obesity, little is known about how BS influences subsequent use of gout medications. We investigated the impact of BS on gout medication…
View details →Golparian A, Anbarian M, Golparian M · 2026 · Journal of biomechanics
Anterior cruciate ligament deficiency (ACLD) leads to knee instability and altered gait patterns. Individuals with ACLD can be classified as copers or noncopers. Lower-limb coordination and coordination variability may reflect compensatory…
View details →Sınır B, Ortan P, Sayin SS et al. · 2026 · Respiratory medicine
Purpose Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and sleep fragmentation, which may alter gut microbiota composition. We primarily aimed to compare intestinal Desulfovibrio detection/abundance between patients…
View details →Kumar A, Sinha RRK, Sahu SP et al. · 2026 · Preprint
Abstract The present experiment was conducted to compare three housing systems Individual cages, Colony cages and Deep litter on welfare, behaviour, and physiological traits in Rhode Island Red laying hens under tropical conditions. A…
View details →Okumura M, Yamagami S, Akiyama M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
Introduction Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode-tissue interface. We evaluated the effects of application repetition and…
View details →Xiang F, Lin J, Chen B et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background To compare the superthin (3-5 mm) versus conventional (≥10 mm) anterolateral thigh (ALT) flap for post-traumatic ankle reconstruction. Methods Retrospective cohort (2020-2024): superthin ALT (n=26) vs conventional ALT (n=34).…
View details →Sabharwal P, Kaur N, Kaur R et al. · 2026 · Journal of ultrasound
Objectives To determine the incremental diagnostic value of multiparametric quantitative ultrasound-integrating B-mode, Color Doppler, Strain, and Shear Wave Elastography (SWE)-in differentiating benign and malignant breast lesions, using…
View details →