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Browse the failure-mode index

21,710 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Prenatal representations of women with minor depressive symptoms: a randomised controlled trial of an interactive ultrasound intervention.

Lindstedt J, Ekholm E, Pulliainen H et al. · 2026 · Journal of reproductive and infant psychology

Background Maternal depressive symptoms are common during pregnancy and may negatively impact the mother-infant relationship, particularly the development of maternal prenatal representations. This study used a randomised controlled trial…

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Negative / Null Result ReportMedicine

Effectiveness and safety of treatment for heterozygous familial hypercholesterolaemia and multifactorial dyslipidaemia in children: an overview of systematic reviews.

Le Thi TG, Geist M, Novosad Y et al. · 2026 · European journal of preventive cardiology

Aims This overview of systematic reviews (SRs) summarizes evidence on effectiveness and safety of treatment for paediatric heterozygous familial hypercholesterolaemia (heFH) and multifactorial dyslipidaemia (MFD). Methods and results…

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Negative / Null Result ReportMedicine

Clinical and microbiological characteristics of multidrug-resistant acute bacterial endophthalmitis after cataract surgery. Endophthalmitis Management Study Report # 8.

Das T, Belenje A, Joseph J et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose Report the clinico-microbiological characteristics of multidrug-resistant acute postcataract bacterial endophthalmitis. Methods Consecutive 32 cases from a prospective multicenter study in India were analyzed for the clinical…

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Negative / Null Result ReportMedicine

Supervised exercise and pelvic floor muscle training eases current pelvic and genital pain but not worst pelvic and genital pain in women with endometriosis: a randomised trial.

Gabrielsen R, Tellum T, Bø K et al. · 2025 · Journal of physiotherapy

Question How much does adding supervised group and independent individual exercise including pelvic floor muscle training (PFMT) to multidisciplinary pain management affect pelvic and genital pain in women with endometriosis? How much does…

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Negative / Null Result Report

Perineural Invasion as a High-Risk Feature Is Not a Predictive Biomarker for Postoperative Adjuvant Radiotherapy in Stage II Low Rectal Cancer: A Retrospective Analysis of a Real-World Cohort

Li X, Yan M, Li T et al. · 2025 · Preprint

Abstract Background Perineural invasion (PNI), though reported with varying incidence in rectal cancer, is a recognized marker of adverse prognosis. While postoperative adjuvant radiotherapy is a cornerstone of multidisciplinary management…

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Negative / Null Result ReportMedicine

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir-ritonavir in patients with COVID-19.

Agyeman AA, Buggiotti L, Brown LK et al. · 2026 · British journal of clinical pharmacology

Aims The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it…

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Negative / Null Result ReportMedicine

Vocal Fundamental Frequency and Generalized Anxiety Disorder: Insights from a Large Multi-Country Cohort in Africa.

Khoshnevis A, Zayernouri M, Malete L et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective Voice-based biomarkers have been proposed as objective tools for anxiety assessment, yet existing research relies on small, demographically homogeneous samples and shows inconsistent associations between fundamental frequency (F…

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Negative / Null Result ReportMedicine

Inter-joint coordination and coordination variability during gait differentiate copers from noncopers in males with anterior cruciate ligament deficiency.

Golparian A, Anbarian M, Golparian M · 2026 · Journal of biomechanics

Anterior cruciate ligament deficiency (ACLD) leads to knee instability and altered gait patterns. Individuals with ACLD can be classified as copers or noncopers. Lower-limb coordination and coordination variability may reflect compensatory…

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Negative / Null Result ReportMedicine

Impact of application repetition on Joule heating and lesion formation using a circular-shaped pulsed field catheter.

Okumura M, Yamagami S, Akiyama M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

Introduction Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode-tissue interface. We evaluated the effects of application repetition and…

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Negative / Null Result ReportMedicine

Clinical study of the superthin anterolateral thigh flap for reconstruction of post-traumatic ankle joint soft-tissue defects.

Xiang F, Lin J, Chen B et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background To compare the superthin (3-5 mm) versus conventional (≥10 mm) anterolateral thigh (ALT) flap for post-traumatic ankle reconstruction. Methods Retrospective cohort (2020-2024): superthin ALT (n=26) vs conventional ALT (n=34).…

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Negative / Null Result ReportMedicine

Exploring iridotrabecular contact index and related factors in primary angle closure disease: a swept-source anterior segment OCT study.

Jeong Y, Park KH, Jeoung JW · 2026 · The British journal of ophthalmology

Background/aims This study evaluates the relationship between the iridotrabecular contact (ITC) index and various anterior segment parameters, with a particular focus on lens-related parameters, given their clinical relevance in primary…

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Negative / Null Result ReportOpen accessMedicine

Lamotrigine serum concentrations as longitudinal biomarkers for seizure risk prediction in pregnant women with epilepsy: a secondary analysis of the EMPiRE study.

Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open

Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…

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Negative / Null Result Report

Addressing Unanswered Questions About the Shift of Strategy Approach: A Multi-Study Investigation of Approach Variations, Repeated Interviews, and Innocent Versus Guilty Responses

Nyström L, Granhag A, Neofotistos E et al. · 2026 · Preprint

Introduction. The Shift-of-Strategy (SoS) approach aims to obtain concealed information from semi-cooperative suspects by prompting them to shift toward more forthcoming counter-interrogation strategies. While previous studies on the…

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