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WASTE Journal

Browse the failure-mode index

21,707 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial.

Schlemmer, Hammer, Fandler-Höfler et al. · 2026 · Nutrients

Background : The plant Griffonia simplicifolia is marketed as a dietary supplement; it is said to have antidepressant and sleep-promoting properties. Its main ingredient, 5-hydroxytryptophan (5-HTP), is the immediate precursor of serotonin…

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Negative / Null Result ReportMedicine

Clinical Strategies to Improve the Accuracy of Articulating Paper for Detecting Occlusal Contact Points in Adults with Natural Dentitions.

Rovira-Lastra, ElOtmani-Sabiri, Ustrell-Barral et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : This clinical study assessed the validity of articulating paper for detecting occlusal contacts points, including examining the effects of clinical technique, paper thickness, and the arch. Methods : This…

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Negative / Null Result ReportMedicine

Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.

Ahmed, Nath, Jahan et al. · 2026 · International journal of environmental research and public health

Conventional anthropometric measures used to predict dyslipidemia, such as body mass index and waist circumference, vary over time and may not fully capture early-life influences on metabolic risk. Fixed skeletal proportions, including…

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Negative / Null Result ReportMedicine

Low-Volume Versus Standard-Volume Pericapsular Nerve Group Block with and Without Dexamethasone for Postoperative Analgesia After Total Hip Arthroplasty: A Randomized Controlled Trial.

Reysner, Ciftci, Alver et al. · 2026 · Journal of clinical medicine

Background: The pericapsular nerve group block provides motor-sparing analgesia after total hip arthroplasty, but the optimal injectate volume and the role of dexamethasone remain unclear. Methods: In this prospective, randomized,…

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Negative / Null Result ReportMedicine

Hope for Romantic Relationships: Validation of a Brief Scale.

Marici, Marina, Cormoș · 2026 · Behavioral sciences (Basel, Switzerland)

This study aimed to develop and validate a brief measure of hope for romantic relationships (HRR), conceptualized as a future-oriented evaluation of relational continuity and quality. The sample consisted of 525 participants. Exploratory…

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Negative / Null Result ReportMedicine

Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.

Petrache, Boldeanu, Diaconu et al. · 2026 · Journal of clinical medicine

Background: Dental caries in children has been explored not only as a local oral condition but also in relation to potential systemic inflammatory changes. This study evaluated systemic inflammatory biomarkers and hematologic indices in…

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Failed Experiment ReportMedicine

Efficacy and safety of belapectin for the prevention of esophageal varices in patients with MASH cirrhosis: The randomized, placebo-controlled NAVIGATE trial.

Chalasani, Vuppalanchi, Noureddin et al. · 2026 · Hepatology (Baltimore, Md.)

Belapectin reduced variceal development in a subgroup of patients with MASH cirrhosis. We report the efficacy and safety of belapectin in patients with MASH cirrhosis and portal hypertension without varices at baseline. NAVIGATE was a…

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Negative / Null Result ReportMedicine

Efficacy of a 10-MDP-Containing Cleaner on the Bond Strength to Saliva Contaminated Dentin.

Hayashi-Wells, Phark, Duarte · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

To evaluate the effect of saliva contamination and a 10-MDP-containing cleaner (Katana Cleaner; Kuraray Noritake, Japan) on the shear bond strength (SBS) of an ultra-mild universal adhesive applied in self-etch mode to human dentin.…

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Negative / Null Result ReportMedicine

Surgical strategy and prognostic factors in very elderly (≥ 75 Years) patients with stage I NSCLC: insights from a propensity score-matched analysis.

Lee, Chao, Shen et al. · 2026 · BMC pulmonary medicine

BACKGROUND: The optimal surgical strategy for very elderly patients (≥ 75 years) with stage I non–small cell lung cancer (NSCLC) remains uncertain. METHODS: We retrospectively analyzed 390 patients with pathologic…

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Negative / Null Result ReportMedicine

Impact of the risk-treatment paradox on in-hospital and long-term outcomes in patients with very high-risk non-ST-elevation acute coronary syndrome.

Nesova, Vorobeva, Ryabov · 2026 · The Indian journal of medical research

Background and objectives The risk-treatment paradox (RTP) has not been studied in very high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). We aimed to describe the cohort of very high-risk NSTE-ACS patients,…

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Negative / Null Result ReportMedicine

Adjuvant capecitabine in women with triple-negative breast cancer with residual disease after carboplatin-containing neoadjuvant chemotherapy.

Tavares, Ramalho, da Silva et al. · 2026 · Breast cancer research and treatment

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by early relapse and limited therapeutic options. Carboplatin added to anthracycline/taxane neoadjuvant chemotherapy (NACT) raises pathologic complete response…

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Negative / Null Result ReportMedicine

Investigating the necessity of preoperative coronary angiography for infection-related cardiac implantable electronic device explantation.

Caldonazo, Scheler, Fischer et al. · 2026 · American heart journal plus : cardiology research and practice

Device-associated endocarditis is a potentially life-threatening condition that typically requires the removal of the cardiac implantable electronic device (CIED). The role of routine coronary angiography (CAG) as part of preoperative…

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Negative / Null Result ReportMedicine

The efficacy of acetic acid and citric acid on calcium silicate based cement removal from root canals and their effect on dentine structure - an in vitro study.

Alzraikat, Al-Hiyasat, Jamous et al. · 2026 · Biomaterial investigations in dentistry

This study evaluated the effectiveness of acids on calcium silicate cement surface hardness, perforation, and their impact on root dentine microstructure. Root dentine discs were exposed to hydrochloric, acetic, and citric acids. Fourier…

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Negative / Null Result ReportMedicine

Effects of omega-3 fatty acid supplementation on heart rate variability.

Atef Abdelsattar Ibrahim, Gouda Kamal, Zid et al. · 2026 · World journal of clinical pediatrics

Obesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability (HRV), a non-invasive indicator of cardiovascular risk. Omega-3 polyunsaturated fatty acids have…

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Negative / Null Result ReportMedicine

Risk Factors Associated with Mortality in Nosocomial Stenotrophomonas maltophilia Pneumonia: A Single-Center Retrospective Study.

Yıldız, Top, Yıldız et al. · 2026 · Mediterranean journal of hematology and infectious diseases

Stenotrophomonas maltophilia ( S. maltophilia ) is a multidrug-resistant pathogen frequently isolated in hospital-acquired pneumonia and represents a significant clinical challenge. This study aimed to investigate the risk factors…

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Short NoteMedicine

DNA repair-associated nucleases induce double-strand breaks following sequential exposure to UVA1 and UVB.

Narimichi, Komaki, Suzuki et al. · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Solar UV comprises UVA and UVB; each exerts distinct biological effects, while their combined impact is not yet fully understood. We previously reported that human keratinocytes exposed to UVA1 followed by UVB irradiation exhibited severe…

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Negative / Null Result ReportMedicine

Inpatient Opioid Use in Head and Neck Microvascular Free Flap Reconstruction.

Timothee, Bliss, Blumenthal et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary…

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