21,253 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kwak N, Kim JY, Kim HJ et al. · 2025 · Tuberculosis and respiratory diseases
Background This study aimed to determine whether a shorter high-dose rifampicin regimen is non-inferior to the standard 6-month tuberculosis regimen. Methods This multicenter, randomized, open-label, non-inferiority trial enrolled…
View details →Sriyanti Sriyanti, Evy Damayanthi, Faisal Anwar · 2019 · Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition
Background : Rosela (Hibiscus sabdariffa L.) is an anthocyanin-rich plant that has good antioxidant capacity. However, the utilization was limited to red roselle, while previous studies showed that anthocyanin content was found to be higher in the thick roselle.therefore, this is an opportunity to develop purple roselle products as a preventive effort for degenerative diseases in men with fatness. Subjects in this study were male by considering the effect of estrogen on women which could play a role in suppressing oxidative stress. Objectives : This study aimed to analyze antioxidant (SOD/Supe
View details →Duangdee Trangsuwan, Malai Wongchanchailert, Ladda Mo-suwan et al. · 2018 · Journal of Health Science and Medical Research (JHSMR)
Objective: To evaluate the volume of blood transfusion requirements as well as hemolytic and oxidative biochemical variables in transfusion-dependent β-thalassemia patients supplemented with vitamin E. Material and Methods: A prospective, double-blind, randomized, placebo-controlled, crossover study was undertaken between December, 2012 and September, 2014 in the Pediatric Clinic of Songklanagarind Hospital. The participants were β-thalassemia major and Hb E/β-thalassemia patients aged between 5 and 18 years. A random allocation sequence was generated to receiving either 6 months of vitamin E
View details →S. Lürzel, K. Barth, I. Windschnurer et al. · 2018 · Animal
Cattle’s relationship with humans is a crucial factor regarding their welfare. In dairy cows, interactions with humans occur regularly during milking. We tested the effect of gentle interactions (stroking, talking in a gentle voice) during milking on avoidance distance and milk composition, yield and flow characteristics as well as behaviour during milking. Over the course of 15 days, an experimenter interacted gently with 14 German Holstein cows for 2 min during morning and evening milkings, totalling 60 min; the experimenter stayed at a similar distance to 12 control cows of the same breed f
View details →Xiang-Gui Chen, Yi-Hua Wu, Neng-Qi Li et al. · 2022 · BMC Plant Biology
Abstract Background Orchids require specific mycorrhizal associations for seed germination. During symbiotic germination, the seed coat is the first point of fungal attachment, and whether the seed coat plays a role in the identification of compatible and incompatible fungi is unclear. Here, we compared the effects of compatible and incompatible fungi on seed germination, protocorm formation, seedling development, and colonization patterns in Dendrobium officinale; additionally, two experimental approaches, seeds pretreated with NaClO to change the permeability of the seed coat and fungi incub
View details →Jasanmol Singh, Ali Bulent Koc, Matias Jose Aguerre et al. · 2024 · Smart Agricultural Technology
Alfalfa is a high-yielding forage crop that is widely grown in the United States for grazing, hay and silage making. A proper maintenance of these grasslands is necessary to ensure optimum productivity and profits. The pre-harvest estimation of biomass yield helps in quantifying the profits and optimizing the forage allocation in advance. Most traditional methods of forage estimation are relatively laborious and time-consuming. Recent developments in contact and remote sensing technologies opened numerous paths for performing aboveground biomass estimation tasks with flexibility and easiness.
View details →Ophélie Vacca, Amel Saoudi, Mathilde Doisy et al. · 2025 · Molecular Therapy: Nucleic Acids
The mdx52 mouse model exhibits a common mutation profile associated with brain involvement in Duchenne muscular dystrophy (DMD), characterized by heightened anxiety, fearfulness, and impaired associative fear learning. Deletion of exon 52 disrupts the expression of two dystrophins found in the brain (Dp427 and Dp140) and is eligible for therapeutic exon-skipping strategies. We previously demonstrated that a single intracerebroventricular administration of an antisense oligonucleotide (ASO) targeting exon 51 of the Dmd gene could restore 5%–15% of Dp427 expression. This treatment reduced anxiet
View details →SHINY JOHN, KAVITARATI DHARWADKAR, MANJUNATH V MOTAGI · 2014 · Journal of Clinical and Diagnostic Research
Background: Cholesterol is especially abundant in nervous system, where it plays important role in different aspects of cellular structure (e.g. fluidity of cell membranes) and function (e.g. membrane). Several studies showed that there may be a link between depression and low cholesterol because of altered central serotonergic functions. On the other hand, some studies also showed either no such association or yielded inconsistent results. However, many studies have related low cholesterol with different psychiatric disorders. Hence, we intend to see the possible link between the two. Aim: To
View details →Geum-Bong Lee, Hyunhee Woo, Su-Yoon Lee et al. · 2019 · PLoS ONE
Background and objective Education of disease plays an important role in management of Parkinson's disease (PD). However, little is known about the link between the understanding of disease and the burden of care. This study was carried out to find the correlation between the burden of care and the understanding of disease in caregivers for PD patients. Methods Non-demented patients with PD and their caregivers participated in structured interviews. Understanding of patients and caregivers was evaluated through newly-devised questions. The caregiver burden inventory was used to assess the burd
View details →Nga Thi Nguyen, Thanh Thi Ngoc Nguyen, Hue Thi Nguyen · 2025 · Ho Chi Minh City Open University Journal of Science - Engineering and Technology
Breast cancer remains a leading cause of mortality among women worldwide. In Vietnam, the rising incidence underscores the urgent need for early diagnostic markers. Genetic factors, particularly Single Nucleotide Polymorphisms (SNPs), play a critical role in breast cancer susceptibility. The SNP rs34678647, located downstream of the miR-221/222 cluster targeting Estrogen Receptor alpha (ERα), is hypothesized to influence breast cancer risk by modulating cancer-related pathways. This study investigates the association between rs34678647 and breast cancer risk in the Vietnamese population. A tot
View details →Chang Mo Moon, Sung-Ae Jung, Seong-Eun Kim et al. · 2015 · PLoS ONE
Diagnostic delay frequently occurs in Crohn's disease (CD) patients because of diagnostic limitations. However, diagnostic delay and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD patient cohort. We performed a multicenter retrospective analysis of 1,047 CD patients registered in the Crohn's Disease Clinical Network and Cohort study in Korea. The mean interval of diagnostic delay was 16.0 ± 33.1 months. Multivariate analysis showed that ol
View details →Zhaleh Shadman, Nooshin Poorsoltan, Mahdieh Akhoundan et al. · 2014 · Journal of Fasting and Health
The aim of this study was to assess public knowledge about the effects of Ramadan fasting on various aspects of health and its association with fasting decision-making. This cross-sectional study was conducted on 600 subjects. The association between fasting and participants’ knowledge and attitudes toward Ramadan fasting, anthropometric measurements, physical activity, depression, anxiety, stress, dietary intake, and prior history of diseases was evaluated. The results indicated an adverse correlation between negative attitudes towards the effects of Ramadan fasting and adherence to fasting (
View details →Kanglai Li, BD, Shangyan Liang, MD, Yuyan Shi, BD et al. · 2021 · Sexual Medicine
Introduction: Dehydroepiandrosterone sulfate (DHEAS) has been reported to be associated with sexual function and general psychological health respectively, however, no one has ever examined their mutual relationships in a single study. Aim: The aim of the present study was to find out whether DHEAS, general psychological health, and erectile function were all associated with each other. Methods: A cross-sectional study was conducted on 34 patients with erectile dysfunction (ED) and 32 healthy controls (HC). The levels of serum DHEAS were assessed by chemiluminescence method. Erectile function
View details →Anne Sofie Frølunde, Jan Brink Valentin, Lise Kristensen et al. · 2026 · Acta Dermato-Venereologica
Dermatophyte infections are common in general practice and occur more often in individuals with type 2 diabetes (T2D), but whether they signal undiagnosed T2D remains unclear. We conducted a register-based cohort study including positive PCR tests for dermatophyte infection from the feet or nails, matched 1:3 to individuals from the same geographic area in Denmark. Those with known diabetes, type 1 diabetes or aged under 20 were excluded. Incidence rates (IRs) and incidence rate ratios (IRRs) for new-onset T2D were estimated using Poisson regression. The final cohort comprised 78,140 individua
View details →Bin Zhang, Hao Guo, Zhou Li et al. · 2025 · BMC Microbiology
Abstract Backgrounds Microbial dysbiosis in the gut and urine has been implicated in patients with benign prostatic hyperplasia (BPH) in previous studies. Additionally, emerging evidence suggests that salivary dysbiosis is associated with various diseases and oral health conditions. Building on these findings, this study aimed to investigate whether BPH patients exhibit a distinct salivary microbiome. Methods and materials We recruited a cohort of BPH patients (n = 50) and age- and BMI-matched healthy controls (HC; n = 50). Salivary samples were collected for 16S rRNA gene sequencing, and pros
View details →Hanan Al-Wakeel, Nadia Sewelam, Mohamed Khaled et al. · 2018 · Egyptian Journal of Medical Human Genetics
Background: Many genetic factors, including polymorphisms in the genes regulating blood coagulation and fibrinolysis have been proposed as risk factors for coronary artery disease (CAD). PAI-1 is the chief inhibitor of tissue plasminogen activator and urokinase plasminogen activator. PAI-1 has a crucial role in regulation of fibrinolysis. Aim of the study: Is to investigate the association between Plasminogen activator inhibitor-1 (PAI-1) 4G/5G, PAI-1C/G polymorphisms and CAD. In addition, studying the relation of these polymorphisms to the level of active PAI-1 in Egyptian patients presenting
View details →Sailimai Man, Yuan Ma, Cheng Jin et al. · 2020 · Journal of Diabetes Research
Background. Studies suggest an association between H. pylori infection and extragastrointestinal disease. Limited studies provided conflicting results on the association between H. pylori infection and diabetes. The present study was aimed at examining the association between H. pylori infection and diabetes in a large health checkup population in China. Methods. A cross-sectional study was conducted; participants who attended health checkups at Beijing MJ Health Screening Center during 2017-2018 were included. H. pylori infection was diagnosed by 13C-urea breath test. Multivariate logistic re
View details →Marjolein M Iversen, Giesje Nefs, Grethe S Tell et al. · 2016 · PLoS ONE
Aim To examine whether elevated anxiety and/or depressive symptoms are related to all-cause mortality in people with Type 2 diabetes, not using insulin. Methods 948 participants in the community-wide Nord-Trøndelag Health Survey conducted during 1995-97 completed the Hospital Anxiety and Depression Scale with subscales of anxiety (HADS-A) and depression (HADS-D). Elevated symptoms were defined as HADS-A or HADS-D ≥8. Participants with type 2 diabetes, not using insulin, were followed until November 21, 2012 or death. Cox regression analyses were used to estimate associations between baseline e
View details →Yeganeh Shekari, Zahra Mahmoodi, Mohammadtaghi Ghorbani Hesari et al. · 2026 · Molecular Pain
Background: Chronic daily headache (CDH) is known to be a common and debilitating disease that is influenced by genetic, dietary, and lifestyle factors. Iron (Fe) plays a key role in energy metabolism and neurotransmitter synthesis, while the FTO gene polymorphism (rs9939609) may play a role in modulating nutritional responses and nutrient metabolism. This study aimed to determine the interaction between CDH odds, dietary iron intake, and FTO genotype. Methods: This case-control study was conducted on 150 CDH patients and 150 healthy individuals aged 40–80 years. Participants were assessed for
View details →Stokbro, Liebregts, Baan et al. · 2026 · Scientific reports
The aim of this study was to evaluate the influences of surgical sequencing on the postoperative occlusion in bimaxillary osteotomies. Patients who underwent bimaxillary surgery without maxillary segmentation, based on a virtual surgical…
View details →Claire Howarth, Christian Mifsud, Christian Mifsud et al. · 2024 · Frontiers in Pediatrics
IntroductionThere is significant uncertainty regarding the role that anaemia or red blood cell transfusion (RBCT) plays in the development of gut injury in preterm infants. This study evaluated Near Infrared Spectroscopy (NIRS) together with a range of known biomarkers of gut inflammation to identify their relationship with anaemia and RBCT.MethodA prospective observational study of preterm infants born at <30 weeks gestation was conducted from birth until either 36 weeks post conceptional age or discharge home. Gut perfusion and biomarkers of gut injury were assessed weekly by: 60 min NIRS me
View details →Chatelaine M. Wansi · 2026 · International Journal of Multidisciplinary Educational Research and Innovation
Physics and engineering are like two peas in a pod; one cannot be complete without the other. Physics is an integral part of the engineering curricula as the latter is founded on principles of our physical world. Thus, understanding the level of physics conceptual comprehension and mathematical proficiency of civil engineering students as well as identifying factors that affect it helps educators, academic institutions, and policy-makers better serve and prepare students as reliable future civil engineers. This research utilized a quantitative research design, specifically a predictive correla
View details →Haure Osman Muhammad Hamadamin, Samir Mahmood Othman · 2026 · Zanco Journal of Medical Sciences
Background and objective: Obesity is a chronic, multifactorial condition characterized by an excessive accumulation of body fat that presents significant health risks. Community pharmacists, for instance, are highly accessible and often serve as the first point of contact for patients seeking advice on weight management. This study aims to fill a research gap by evaluating community pharmacists’ knowledge, attitudes, and practices related to obesity and weight management. Methods: A cross-sectional study was carried out among 331 community pharmacists among different pharmacy settings in Erbil
View details →Hatice Özyılmaz, Serdar Bağlar · 2026 · BMC Public Health
Abstract Background Adolescence is a critical milestone in the transition to adulthood. Factors affecting oral health, an essential component of general health during this period, also influence public health. This study investigates the potential impact of parental education level (PEL) and daily total daily screen time (DTST) on adolescent oral health using a large sample size. Methods A total of 1300 adolescents aged 17 and 18 from Ordu Province were included in this study. A structured questionnaire was used to assess PEL, DTST, and other habits that may influence dental caries. Oral healt
View details →Michinobu Umakoshi, Akiko Nakamura, Hiroyuki Tsuchie et al. · 2023 · Scientific Reports
Abstract Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological studies, which are important for clarifying pathophysiology. Here, we examined tumor-associated macrophages in the intratumoral and marginal areas of sarcomas to increase our knowledge about the pathophysiology. Seventy-five sarcoma specimens (not limited to a single histological type), resected at our institution, were collected, and the number of CD68-, CD163-, and CD204-posit
View details →N Bushra Thasneem, Resmi S. Kaimal, Abdul Hakeem Thengu Murichathil · 2025 · Journal of Family Medicine and Primary Care
Introduction: Anaemia is one of the significant public health problems faced by developing countries. It occurs more frequently in women of childbearing age. Anaemia causes poor work capacity, and severe forms may even cause cardiac failure. In pregnant women, anaemia may lead to preterm labour, low-birth-weight babies, and increased risk of maternal mortality due to post-partum haemorrhage. Even though there are national programmes to supply iron free of cost and other measures to tackle anaemia, it is still prevalent in our country. Anaemia prevalence has increased between NFHS-4 and NFHS-5,
View details →Mylène Duivon, Joy Perrier, Carine Segura-Djezzar et al. · 2022 · Frontiers in Neuroscience
BackgroundPrevious studies have revealed both sleep alterations and prospective memory (PM) impairments in breast cancer (BC) patients. PM refers to memory of intended actions and is crucial for daily living tasks and treatment compliance. As sleep is known to favor memory consolidation, one may expect that changes in sleep quality related to BC would have an impact on PM performance. This study aimed at assessing sleep-dependent consolidation of intentions using an ecological, virtual reality-based PM task in BC patients not treated with chemotherapy.Materials and methodsThirty-seven early st
View details →Farzaneh Dasturian, Nadereh Naderi, Gholamreza Farshidfar et al. · 2020 · Brazilian Journal of Cardiovascular Surgery
Abstract Objective: To investigate the association between interleukin-35 (IL-35) levels and single nucleotide polymorphisms (rs3761548, rs3761547) of the FoxP3 gene in coronary artery bypass grafting (CABG) patients. Methods: We conducted a prospective study including 140 patients, who were scheduled for elective isolated on-pump CABG with cardiopulmonary bypass (CPB) from January 2017 to September 2018 in the Jorjani heart center. Blood samples were collected before and 12 hours after the operation. Serum levels of IL-35 were measured by enzyme-linked immunosorbent assay and the pattern of g
View details →Hye‐Sun Park, Sang Ho Park, Yeseul Seong et al. · 2024 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background The association between the adiponectin‐to‐leptin ratio (A/L ratio) and the risk of incident chronic kidney disease (CKD) is poorly understood. This study aimed to investigate the association between A/L ratio and the risk of incident CKD and to examine whether such a relationship varied according to sex and body composition. Methods In this prospective community‐based cohort, participants with normal kidney function were analysed (N = 5192). The association between the A/L ratio at baseline and the risk of incident CKD, defined as two or more occasions with an estimated gl
View details →Lertwiram P, Fuangfa P, Kijkunasathian C et al. · 2026 · Scientific reports
Arthroscopic rotator cuff repair (ARCR) generally improves clinical outcomes, but the impact of pre-existing glenohumeral osteoarthritis (GHOA) severity on these outcomes remains unclear. This study aims to evaluate the correlation between…
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