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Browse the failure-mode index

21,697 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Reperfusion grade and clinical outcome following medium vessel occlusion thrombectomy in the Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions (ESCAPE-MeVO) trial.

Diprose W, Fahed R, Volders D et al. · 2026 · Journal of neurointerventional surgery

Background Randomized trials showed that endovascular thrombectomy (EVT) did not improve outcomes in medium vessel occlusion (MeVO) stroke compared with usual care. We investigated whether patients randomized to EVT who achieved…

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Negative / Null Result ReportMedicine

[A Case of Robot-Assisted Thoracoscopic Extended Thymectomy for Thymoma Associated with Generalized Myasthenia Gravis].

Yamaguchi T, Akai S, Uozumi N et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy

A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed…

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Negative / Null Result ReportMedicine

Pearls & Oy-Sters: Plantar Agraphesthesia in Corticobasal Syndrome.

Perkins JA, Price RS, Vizcarra JA · 2026 · Neurology

We describe a 70-year-old man with no significant medical history who developed progressive left leg numbness, gait dysfunction, and recurrent falls. Within a year, he reported difficulty with both initiating steps and perceiving his left…

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Negative / Null Result ReportOpen accessMedicine

Association between NT-proBNP and ivabradine in patients after noncardiac surgery: a per-protocol analysis of the PREVENT-MINS study.

Gorka J, Putowski Z, Wludarczyk A et al. · 2025 · Anaesthesiology intensive therapy

Background The PREVENT-MINS trial investigated whether perioperative heart rate reduction with ivabradine could prevent myocardial injury after noncardiac surgery (MINS). Although ivabradine modestly reduced heart rate, it did not reduce…

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Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Patent Foramen Ovale and Stroke–Current Status

Oh Young Bang, Mi Ji Lee, Sookyung Ryoo et al. · 2015 · Journal of Stroke

Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This

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Negative / Null Result ReportMedicine

Plasma exchange for severe alveolar hemorrhage in antineutrophil cytoplasmic antibody-associated vasculitis: emulation of a target trial.

Sanna AC, Gendreau S, Desnos C et al. · 2026 · American journal of respiratory and critical care medicine

Rationale Patients with severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-related diffuse alveolar hemorrhage (DAH) face high mortality. In the PEXIVAS trial, plasma exchange (PLEX) did not reduce death or…

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Null DatasetOpen accessMaterials of engineering and construction. Mechanics of materials

Aluminium trihydroxide in combination with ammonium polyphosphate as flame retardants for unsaturated polyester resin

· 2009 · eXPRESS Polymer Letters

The thermal and reaction to fire characteristics of a flame retardant unsaturated polyester (UP) ternary system are presented here. Thermal gravimetric analysis showed an improved thermal stability between 200–600°C with the addition of ammonium polyphosphate (APP) and aluminium trihydroxide (ATH) formulation. Cone calorimetry tests indicated that ATH is more efficient than calcium carbonate at delaying the ignition time, lowering the carbon monoxide yield and lowering the peak heat release (PHRR). However the addition of APP and ATH to the formulation failed to demonstrate any significant syn

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Negative / Null Result ReportOpen accessMedicine

Research Communication: Effects of Screening Colonoscopy on Colorectal Cancer Mortality: Lessons From Comparative Analyses of Randomised Trials.

Brenner H, Sergeev D, Heisser T et al. · 2025 · Alimentary pharmacology & therapeutics

NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with…

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Negative / Null Result ReportOpen accessMedicine

Joint hypermobility in children with and without functional constipation

Seyed Mohammadreza Fatemi Khorasgani, Neda Ramezani, Negar Ebrahimi Varnousfaderani · 2020 · Journal of Research in Medical Sciences

Background: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic. Materials and Methods: In this case–control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control gr

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Negative / Null Result ReportOpen accessPublic aspects of medicine

Interaction of household air pollution and healthy lifestyle on the risk of sarcopenia: China Health and Retirement Longitudinal Study

Tao Zeng, Xinliang Liao, Jie Wu · 2025 · Environmental Health and Preventive Medicine

Background: Exposure to air pollution and adherence to a healthy lifestyle have been identified to be related to sarcopenia. However, the interactive effects between these two factors remain insufficiently elucidated. The present study was designed to investigate the potential interaction exposure to air pollution with healthy lifestyle on the risk of developing sarcopenia. Methods: In the retrospective cohort study, all data was extracted from China Health and Retirement Longitudinal Study. Household air pollution was assessed based on the utilization of solid fuels for cooking and heating. A

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Negative / Null Result ReportOpen accessMedicine (General)

Evaluating ovarian blood supply anatomy and variability via digital subtraction angiography in patients with cesarean scar pregnancy undergoing uterine artery embolization

Guo Zheng, Huiling Gao, Zhao Jin et al. · 2026 · Frontiers in Medicine

BackgroundPreservation of ovarian perfusion is a critical consideration during uterine artery embolization (UAE), as inadvertent disruption can reduce ovarian reserve. Given the complex and variable anatomy of ovarian blood supply, this study aimed to characterize its anatomical origins and variations using digital subtraction angiography (DSA) in patients undergoing UAE for cesarean scar pregnancy (CSP).MethodsThis retrospective study included patients with type II or III CSP who underwent first-time UAE at Heibei Maternity Hospital, China, between August 2020 and October 2024. Pre-embolizati

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Negative / Null Result ReportOpen accessHuman anatomy

Odontoid process angulation range in a South African skeletal population sample: An osteological study

Ricardo Jonker, Glen J. Paton, Shahed Nalla · 2025 · Translational Research in Anatomy

Background: This study investigated the angulation of the odontoid process in a South African skeletal population to establish normative vertical angulation in the sagittal plane and assess variations across population affinity groups, biological sexes, and age categories. The study also investigated standardizing techniques for measuring the angle of the odontoid process. Methods: A cross-sectional study was conducted on 200 cervical axis vertebrae from the Raymond A. Dart Collection. Angulation measurements were taken using digital photographs, ImageJ software and statistical analyses (one-w

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Negative / Null Result ReportOpen accessMedicine

Comparative Evaluation of Buffy Coat-Derived and Apheresis Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia: Laboratory and Clinical Insights.

Huang C, Wu M, Li Y et al. · 2026 · Clinical, cosmetic and investigational dermatology

Background Androgenetic alopecia (AGA) is the most common type of hair loss, and platelet-rich plasma (PRP) has emerged as a promising therapy. However, preparation methods may influence clinical outcomes. Objective To compare buffy coat…

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Negative / Null Result ReportOpen accessMedicine

Enhancing Port Performance through Digital Transformation: The Role of Networking Capability and Organizational transformation in Indonesian Container Ports.

Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · F1000Research

Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…

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Negative / Null Result ReportMedicine

Investigating farmers' preferences for rapeseed sales contracts in Iran.

Mehrabi A, Mohamadi-Nejad A, Ghorbani M et al. · 2026 · Brazilian journal of biology = Revista brasleira de biologia

Contract farming has gained popularity in recent years. Understanding farmers' preferences for contracts can help make contracts more sustainable and profitable. Therefore, the present study aimed to investigate farmers' preferences for…

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Negative / Null Result ReportMedicine

A comparison of the effects of cognitive rehabilitation and binaural beats on creativity, psychological well-being, and academic performance in university students.

Bayrami M, Dadashi Mazraeh S · 2026 · Acta psychologica

This study compared the effects of cognitive rehabilitation and binaural beats on creativity, psychological well-being, and academic performance in 45 undergraduate students using a quasi-experimental pretest-posttest design with a control…

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Negative / Null Result ReportOpen accessMedicine

Alleviation of temperature stress in maize by integration of foliar applied growth promoting substances and sowing dates.

Irfan Afzal, Shakeel Imran, Talha Javed et al. · 2022 · PLoS ONE

Temperature is a key factor influencing plant growth and productivity, but its sudden rise can cause severe consequences on crop performances. Early sowing and application of growth promoting agents as a foliar spray can be a sustainable approach to cope with high temperature stress at grain filling stage of cereal crops. Therefore, a test was designed to explore the potential of different growth helping agents including sorghum water extract (SWE, 10 ml L-1), moringa leaf extract (MLE, 3%), hydrogen peroxide (H2O2, 2 μM), salicylic acid (SA, 50 mg L-1) and ascorbic acid (ASA, 50 mg L-1) as fo

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Negative / Null Result ReportOpen accessAnimal culture

Consumo de volumosos, produção e composição físico-química do leite de cabras F1 Boer Saanen Roughage intake, milk yield and physicochemical composition from F1 Boer Saanen goats

Elisa Köhler Osmari, Ulysses Cecato, Francisco de Assis Fonseca de Macedo et al. · 2009 · Revista Brasileira de Zootecnia

Avaliaram-se os efeitos do fornecimento de volumosos suplementares sobre o consumo, a produção e a composição físico-química do leite de cabras F1 (Boer Saanen). Utilizaram-se 18 cabras distribuídas em três baias, recebendo como suplemento, à vontade, silagem de sorgo, silagem de milho ou feno de amoreira com controle diário do consumo de matéria seca. A média diária para produção semanal foi calculada reunindo-se dados leiteiros em três períodos pós-parto: 1 (34 a 40 dias/7 dias); 2 [(64 a 70 dias/7 dias) + (91 a 97 dias)/7 dias)]/2; e 3 (125 a 131 dias/7 dias) e a média pontual diária do per

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Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Clinical determinants and prognostic implications of renin and aldosterone in patients with symptomatic heart failure

Masatake Kobayashi, Susan Stienen, Jozine M. terMaaten et al. · 2020 · ESC Heart Failure

Abstract Aims Activation of the renin–angiotensin–aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis. There are limited data on the associations of renin and aldosterone levels with clinical profiles, treatment response, and study outcomes in patients with HF. Methods and results We analysed 2,039 patients with available baseline renin and aldosterone levels in BIOSTAT‐CHF (a systems BIOlogy study to Tailored Treatment in Chronic Heart Failure). The primary outcome was the composite of all‐cause mortality or HF ho

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Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics

Investigation of scanning parameters for thyroid fine needle aspiration cytology specimens: A pilot study

Maheswari S Mukherjee, Amber D Donnelly, Elizabeth R Lyden et al. · 2015 · Journal of Pathology Informatics

Background: Interest in developing more feasible and affordable applications of virtual microscopy in the field of cytology continues to grow. Aims: The aim of this study was to investigate the scanning parameters for the thyroid fine needle aspiration (FNA) cytology specimens. Subjects and Methods: A total of twelve glass slides from thyroid FNA cytology specimens were digitized at ×40 with 1 micron (μ) interval using seven focal plane (FP) levels (Group 1), five FP levels (Group 2), and three FP levels (Group 3) using iScan Coreo Au scanner (Ventana, AZ, USA) producing 36 virtual images (VI)

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