Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Yin Liu, Y Gong, X. Zhu et al. · 2025 · BMJ
Abstract Objective To evaluate the efficacy and safety of epirubicin and cyclophosphamide followed by weekly paclitaxel with or without carboplatin as adjuvant therapy for patients with high risk, early stage, triple negative breast…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lucia Scisciola, Manuela Giovanna Basilicata, Marta Belmonte et al. · 2026 · Nutrients
BACKGROUND: The heart depends on a continuous and flexible energy supply from fatty acids, glucose, and other substrates. Emerging evidence shows that gut microbiota-derived metabolites-such as trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), secondary bile acids, indoles, phenylacetylglutamine (PAGln), and branched-chain amino acids-modulate cardiac metabolism and function. Although clinical evidence linking these metabolites to cardiovascular outcomes is expanding, most data remain associative, with limited causal or interventional proof. METHODS: A comprehensive narrative rev
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Suresh Raja Neethirajan · 2026 · Agriculture
Digital twin technology is widely promoted as a transformative step for precision live-stock farming, yet no fully realized, engineering-grade digital twins are deployed in commercial dairy or poultry systems today. Existing platforms are better described as near-digital-twin systems with partial sensing and modelling, digital-twin-inspired prototypes, simulation frameworks or decision-support tools that are often labelled as twins despite lacking continuous synchronization and closed-loop control. This distinction matters because the empirical foundation supporting many claims remains limited
View details →Negative / Null Result ReportOpen accessHealth Professions
Ghassan M. Khairallah, Samar Al‐Hajj, Hani O. Mowafi et al. · 2025 · BMC Public Health
BACKGROUND: Healthcare workers (HCWs) are exposed to a multitude of hazards in the hospital environment, increasing their risks of sustaining injuries at a higher rate compared to workers in other sectors and resulting in substantial level…
View details →Replication FailureOpen accessMedicine
Jeremy M. Shefner, Merit Cudkowicz, Angela L. Genge et al. · 2025 · JAMA Neurology
Importance: Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective: To assess the effect of reldesemtiv vs…
View details →Negative / Null Result ReportOpen accessDentistry
Patrick Golletz, Sissel Damsbo Jensen, Madeline Collignon et al. · 2025 · Journal of Oral Microbiology
Introduction: Coaggregation may reduce the abundance of bacteria in physiological fluids, such as saliva, as aggregated bacteria are cleared more easily than planktonic cells. This study aimed to identify Lactobacillus strains that…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ruiyi Tian, Xiaoyu Zong, Duo Ren et al. · 2026 · Nature Medicine
Abstract Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965–1974 versus 1950–1954, and was associated with early-onset solid cancer r
View details →Negative / Null Result ReportOpen accessMedicine
Mathilde Duchon, Raj Naik, Fabrice R Lecuru et al. · 2025 · Cancers
Background: The surgical and medical management of recurrent ovarian cancer is complex and requires a personalized approach based on several factors, including the timing of recurrence, the patient’s performance status, previous treatment regimens, and the tumor’s histology and molecular characteristics. Objectives: Five randomized trials—GOG-0213, DESKTOP III, SOC 1, HORSE, and CHIPOR—have been conducted and shed light on our practice. Results: Both the DESKTOP III and the SOC 1 trials support the benefit of secondary surgery. The GOG-0213 trial, however, did not show an overall survival bene
View details →Negative / Null Result ReportOpen accessPsychology
Joaquin A. Anguera, Aleem Choudhry, Michael Seaman et al. · 2025 · JMIR Formative Research
Background There is evidence that cognitive training interventions can positively impact executive functions, and that some studies have demonstrated that athletes typically exhibit greater accuracy and faster response times on select cognitive tasks. While the engagement of executive functions is suggested to be part of high-level sporting activities, it is unclear whether such training approaches could directly benefit athletic performance. Objective The objective of this study was to evaluate the impact of a combined virtual reality (VR)– and tablet-based cognitive training intervention on
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Luyanda Majenge, Sakhile Mpungose, Simiso Msomi · 2025 · Energies
The transition of South Africa from coal-dependent energy systems to renewable energy alternatives presents economic and environmental trade-off complexities that require empirical investigation. This study employed threshold-switching dynamic models, NARDL analysis, and threshold Granger causality tests to investigate nonlinear relationships between renewable energy generation, economic growth, and carbon dioxide emissions in South Africa from 1980 to 2023. The threshold-switching dynamic models revealed critical structural breakpoints: a 56.4% renewable energy threshold for carbon dioxide em
View details →Negative / Null Result ReportOpen accessComputer Science
Christian Basil Omeh, Musa Adekunle Ayanwale, Lindelani Mnguni et al. · 2025 · Journal of New Approaches in Educational Research
Abstract Despite the increasing emphasis on computational literacy in higher education, we observed that many undergraduate students particularly in developing contexts struggle to master fundamental programming skills and develop critical thinking. Conventional instructional approaches often lack interactivity and personalized scaffolding, which are essential for teaching abstract programming concepts. In response to this challenge, we examined the effect of artificial intelligence (AI)-assisted problem-based learning (PBL) on students’ programming skills, critical thinking, and problem-solvi
View details →Replication FailureOpen accessMedicine
Mrudula Kanakapura Peramalaiah, Sanjay Tejraj Parmar, Nariman Sepehri et al. · 2025 · JMIR Rehabilitation and Assistive Technologies
BACKGROUND: Children with neurodevelopmental disorders, such as cerebral palsy (CP), often experience motor impairments in manual dexterity, which hinder daily tasks and social interactions. Traditional rehabilitation methods require repetitive task practice, which can be difficult for children to sustain due to low engagement. Game-based rehabilitation devices and robots offer a promising alternative by combining therapy with digital play, improving motivation and compliance. However, many systems fail to incorporate actual object manipulation, which is essential for motor learning through se
View details →Negative / Null Result ReportOpen accessMedicine
Thu Ha Dang, Nilmini S. Wickramasinghe, Prem Prakash Jayaraman et al. · 2024 · JMIR Formative Research
BACKGROUND: Medication nonadherence is a serious problem in cancer, potentially impacts patients' health outcomes and health care costs. Although technology-based medication adherence (MA) interventions have emerged, evidence supporting their quality and effectiveness remains limited. OBJECTIVE: This study tested the acceptability, feasibility, and potential effects of Safety and Adherence to Medications and Self-care Advice in Oncology (SAMSON), a digital solution designed to support MA and self-management in cancer. METHODS: A 12-week, 2-arm, unblinded, pragmatic pilot randomized controlled
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Xiangdong Ji, Yang Chen · 2026 · Nuclear Physics B
Momentum current density (MCD) $T^{ij}$ is a general physics concept describing the momentum conservation through momentum flow generated from both the kinetic motion of particles and the interacting forces among them. It has been suggested by M. Polyakov et al. that the MCD in the nucleon, characterized by the form factor $C/D$ of the QCD energy-momentum tensor, can be interpreted as the pressure and shear forces between adjacent parts of the system because the nucleon interior approximates a continuous medium. While intuitively appealing, we find that the interpretation is hard to justify fr
View details →Negative / Null Result ReportOpen accessSocial Sciences
Brooklyn Walker, Paul A. Djupe, Brian Calfano et al. · 2025 · Perspectives on Politics
Popular narratives suggest that the effects of Christian nationalism should be more heavily concentrated among white Americans. The academic literature on Christian nationalism largely reflects this take, often asserting that it is effectively white Christian nationalism. We question such pronouncements, as they have come without systematic analysis across the broad range of issue areas needed to justify subgroup segmentations. Utilizing national oversamples of Black and Latino Christians (alongside white Christians), we assess the relationship between standard measures of Christian nationalis
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Himanshu Chaudhary, Vipin Kumar Sharma, Salvatore Capozzıello et al. · 2026 · The Astrophysical Journal Supplement Series
Abstract Observational data play a pivotal role in identifying cosmological models that are both theoretically consistent and empirically viable. In this work, we investigate the level of preference for dynamical dark energy over a cosmological constant using current late-time observational datasets, including cosmic chronometers (CC), baryon acoustic oscillations from Dark Energy Spectroscopic Instrument (DESI) DR2, and different Type Ia supernova catalogs (Pantheon + , DES-Dovekie, Union3). We analyze various dynamical dark-energy models, including ω CDM, o ω CDM, ω 0 ω a CDM, logarithmic, e
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alessia Paganelli, Federica Papaccio, Mauro Picardo et al. · 2025 · Frontiers in Pharmacology
Vitiligo is a chronic autoimmune condition characterized by the destruction of melanocytes, leading to patchy loss of skin depigmentation. Although its precise cause remains unclear, recent evidence suggests that metabolic disturbances, particularly oxidative stress and mitochondrial dysfunction, may play a significant role in the pathogenesis of the disease. Oxidative stress is thought to damage melanocytes and trigger inflammatory responses, culminating in melanocyte immune-mediate destruction. Additionally, patients with vitiligo often exhibit extra-cutaneous metabolic abnormalities such as
View details →Negative / Null Result ReportOpen accessHealth Professions
Guozheng Wang, Xiaoxia Liu, Yiming Cai et al. · 2025 · Journal of NeuroEngineering and Rehabilitation
BACKGROUND: Tai Chi (TC) is recognized for enhancing balance and postural control. However, studies on its effects on the central nervous system are limited and often involve static experiments despite the dynamic nature of TC. This study…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Tamara Evstafyeva, Nils Peter Siemonsen, William E. East · 2026 · Physical review. D/Physical review. D.
We reinvestigate the stability properties of ultracompact spinning boson stars with a stable light ring using fully nonlinear 3+1 and 2+1 numerical relativity simulations and two different formulations of the Einstein equations. We find no…
View details →Negative / Null Result ReportOpen accessMedicine
Sofia Asioli, Lidia Gatto, Uri Vardy et al. · 2024 · Cancers
Background: Glioblastoma IDH-wildtype (GBM IDH-wt) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping its tumor microenvironment (TME) regulate tumor progression and treatment response. The aim of this study was to characterize the main immunosuppressive elements of the GBM IDH-wt TME. Methods: Immunohistochemistry for CD3, CD4, CD8, CD163, programmed death ligand 1 (PD-L1) and programmed death 1 (PD1) was performed on surgical tumor specimens from patients diagnosed with GBM IDH-wt, according to the CNS WHO 202
View details →Negative / Null Result ReportOpen accessSocial Sciences
Peter Eshak Nashed Soliman, Reham Beram · 2025 · Journal of the Knowledge Economy
Abstract In the face of escalating unemployment rates and the pressing demand for sustainable development, this paper examines the dynamic interplay between technological innovation, information and communications technology (ICT), financial inclusion, and governance quality—key components of the knowledge-based economy and the Sustainable Development Goals (SDGs) 9 and 16—on unemployment (SDG 8) across diverse regions. Using a panel dataset spanning 2004 to 2020 for five regions (Middle East and North Africa, Sub-Saharan Africa, Latin America, Asia, and Europe), a dynamic two-step system gene
View details →Negative / Null Result ReportOpen accessMedicine
Lion Stammen, Eva J I Hoeijmakers, Thomas G. Flohr et al. · 2025 · European Radiology
OBJECTIVES: To evaluate diagnostic image quality (IQ) for pulmonary embolism detection in photon-counting detector CT (PCD-CT) with significantly reduced contrast media (CM) dose vs conventional energy-integrating detector CT (EID-CT), using optimized and individualized CM protocols. MATERIALS AND METHODS: Consecutive CT pulmonary angiography (CTPA) scans performed on the EID-CT (Jan 2024-Mar 2024) with an individualized kilovoltage (kV) and total body weight (TBW) adapted CM protocol, and on the PCD-CT (Aug 2023-Feb 2024) with a TBW adapted CM protocol matching the 70 kV EID-CT protocol, were
View details →Negative / Null Result ReportOpen accessMedicine
Jijuan Zhang, Hancheng Yu, Tingting Geng et al. · 2025 · BMC Medicine
BACKGROUND: Accelerated aging is a dynamic process, yet few studies examined the association of changes in accelerated aging with cardiovascular disease (CVD) and mortality. This study aims to evaluate this association in three prospective…
View details →Replication FailureOpen accessMedicine
Sara A. Hurvitz, Rachel M. Layman, Giuseppe Curigliano et al. · 2026 · Journal of Clinical Oncology
PURPOSE Gedatolisib potently targets all four class I PI3K isoforms and mTORC1 and mTORC2 to comprehensively block the PI3K/AKT/mTOR pathway and has shown compelling activity in early clinical trials with palbociclib and fulvestrant.…
View details →Negative / Null Result ReportOpen accessNeuroscience
Louis Roberts, Juho Äijälä, Florian Bürger et al. · 2026 · Nature Communications
The cortex generates diverse neural dynamics, ranging from broadband fluctuations to narrowband oscillations at specific frequencies. Here, we investigated whether broadband and oscillatory dynamics play different roles in the encoding and transmission of visual information. We used information-theoretical measures to dissociate neural signals sharing common information (i.e., redundancy) from signals encoding complementary information (i.e., synergy). We analyzed electrocorticography (ECoG) and local field potentials (LFP) in the visual cortex of human and non-human primates (macaque) to inve
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Forest ISBELL, A. Mori, Michel Loreau et al. · 2026 · Nature
Stability can be desirable for many natural and social systems. Temporal stability, the invariability of a system over time, can be enhanced by resisting displacement during perturbations, accelerating recovery after them, or both1–4.…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
George Yumnam, Parul R. Raghuvanshi, J. D. Budai et al. · 2025 · Cell Reports Physical Science
We provide experimental evidence for the absence of a magnetic moment in bulk RuO 2 , a candidate altermagnetic material, by using a combination of Mössbauer spectroscopy, nuclear forward scattering, inelastic X-ray and neutron scattering,…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
M. Rossi, Stefania Salvadori, Á. Skúladóttir et al. · 2025 · The Astrophysical Journal
Abstract The elusive properties of the first (Population III or Pop III) stars can be indirectly unveiled by uncovering their true descendants. To this end, we exploit our data-calibrated model for the best-studied ultrafaint dwarf galaxy (UFD), Boötes I, which tracks the chemical evolution (from carbon to zinc) of individual stars from their formation to the present day. We explore the chemical imprint of Pop III supernovae (SNe), with different explosion energies and masses, showing that they leave distinct chemical signatures in their descendants. We find that UFDs are strongly affected by
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chan Seok Lim, Jisun Lee, Jisun Lee et al. · 2025 · Nature Communications
SUMMARY We report the cryo-EM structures of clusters of TNF receptor family proteins, TNFR1 and BAFFR. The receptor-ligand complexes were anchored to a flat lipid layer to mimic the membrane-bound state. We observed that the TNFα-TNFR1…
View details →Negative / Null Result ReportPsychology
Gorn Huvanandana, Peerayuth Charoensukmongkol · 2026 · International Journal of Workplace Health Management
Purpose Grounded in conservation of resources theory, this study investigates how digital leadership influences AI-related job insecurity, AI use anxiety, technostress, and emotional exhaustion. Innovative climate is proposed as the work…
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