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Browse the failure-mode index

21,252 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Failure to Replicate: A Sign of Scientific Misconduct?

Helene Hill, Joel Pitt · 2014 · Publications

Repeated failures to replicate reported experimental results could indicate scientific misconduct or simply result from unintended error. Experiments performed by one individual involving tritiated thymidine, published in two papers in…

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Negative / Null Result Report

Less risk of patellofemoral degeneration without significant clinical and survivorship difference for distal tibial tuberosity high tibial osteotomy compared to biplanar high tibial osteotomy over a mid-term follow-up

Ke Li, Hengbing Guo, Fenglong Sun et al. · 2024 · Journal of Orthopaedic Surgery

Purpose This study aims to compare the mid-term radiographic, clinical results and survivorship between distal tibial tuberosity high tibial osteotomy (DTT-HTO) and conventional biplanar medial open-wedge high tibial osteotomy (cOW-HTO).…

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Negative / Null Result Report

Significant Differences and Experimental Designs Do Not Necessarily Imply Clinical Relevance: Effect Sizes and Causality Claims in Antidepressant Treatments

Iván Sánchez-Iglesias, Celia Martín-Aguilar · 2023 · Journal of Clinical Medicine

Clinical trials are the backbone of medical scientific research. However, this experimental strategy has some drawbacks. We focused on two issues: (a) The internal validity ensured by clinical trial procedures does not necessarily allow…

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Failed Experiment Report

Four Reasons Why Heterodox Academy Failed

Nathan Cofnas · 2022 · Academic Questions

Seven years ago, under the leadership of Jonathan Haidt, Heterodox Academy set out to organize a meaningful resistance to the reigning social justice orthodoxy on campus. “Seven years later,” writes Nathan Cofnas, “you can count HxA’s…

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Negative / Null Result Report

Did the Inclusion of China’s A‐Shares in the MSCI Index Improve the Information Content of Listed Firms? Analysis Based on Stock Price Synchronisation and Environmental Social Governance

Jing Wu · 2022 · Wireless Communications and Mobile Computing

Chinese A‐shares were officially included in the Morgan Stanley Capital International (MSCI) Emerging Markets Index from June 2018. The inclusion of the A‐share market into the MSCI Index is one of the most influential events in the…

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Negative / Null Result Report

Outcome of transanal advancement flap repair (TAFR) as salvage therapy after failed ligation of intersphincteric fistula tract (LIFT)—A proposed algorithm after failed LIFT

E. Ergüder, C. Verkade, C. Ersak et al. · 2025 · Colorectal Disease

Abstract Aim To assess the outcomes of transanal advancement flap repair (TAFR) following failed ligation of intersphincteric fistula tract (LIFT) treatment for cryptoglandular anal fistulas, with a focus on healing and functional results.…

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Negative / Null Result Report

Analysis of Pediatric Pulpotomy, Pulpectomy, and Extractions in Primary Teeth Revealed No Significant Association with Subsequent Root Canal Therapy and Extractions in Permanent Teeth: A Retrospective Study

Arash Farhadian, Mayce Arreem Issa, Karl Kingsley et al. · 2024 · Pediatric Reports

Recent evidence suggests that an ever-growing number of pediatric patients require invasive treatments such as root canal therapy (RCT) in their permanent dentition, albeit with little information about risk factors such as prior invasive…

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Negative / Null Result Report

Association of Diuretic Dosage With Outcomes in Patients With Hemodynamically Significant Isolated Tricuspid Valve Regurgitation

Vidhu Anand, Christopher G. Scott, Khaled Ali et al. · 2025 · Journal of the American Heart Association

Background Tricuspid valve surgery is recommended for severe isolated tricuspid regurgitation (TR) if symptoms persist despite optimal medical therapy. The definition of optimal therapy for TR is unclear beyond managing underlying…

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Negative / Null Result Report

How Did Second Clement Originally End?

James A. Kelhoffer · 2018 · Early Christianity

Eine sprachliche Analyse der stilistischen und theologischen Eigenheiten von 2Clem 19,1–20,5 im Vergleich zu 2Clem 1–18 macht einige Unterschiede deutlich, die für die letzten beiden Kapitel sehr wahrscheinlich auf einen späteren Autor…

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Negative / Null Result Report

Where did they come from, where did they go? Niche conservatism in woody and herbaceous plants and implications for plant‐based paleoclimatic reconstructions

Zack J. Quirk, Selena Y. Smith, R. Paul Acosta et al. · 2024 · American Journal of Botany

Abstract Premise The ecological conditions that constrain plants to an environmental niche are assumed to be constant through time. While the fossil record has been used previously to test for niche conservatism of woody flowering plants,…

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Negative / Null Result Report

Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer*

Shaojun Nong, Yangbo Guan, Zhiwei Wang et al. · 2019 · Oncology and Translational Medicine

Abstract Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4 (OCT4) and interleukin-18 (IL-18) to be related to cancer. However, the molecular mechanisms by which the IL-18 and OCT4 gene…

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Negative / Null Result Report

A medication-wide association study to identify medications associated with incident clinically significant diabetic retinopathy

Ruilin Xiong, Wei Wang, Xianwen Shang et al. · 2023 · Therapeutic Advances in Ophthalmology

Background: Diabetic retinopathy, a common microvascular complication of diabetes mellitus, is one of the leading causes of vision loss worldwide. Although some oral drugs have been suggested to affect the risk of diabetic retinopathy,…

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Negative / Null Result Report

When biology takes over: TV formats like The Bachelor and The Bachelorette confirm evolutionary theories of partner selection

Alexandra Lenhard, Marie-Pierre Minten, Wolfgang Lenhard · 2023 · Frontiers in Psychology

Introduction In this study, we investigated the impact of age on mate selection preferences in males and females, and explored how the formation and duration of committed relationships depend on the sex of the person making the selection.…

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Negative / Null Result Report

Conventional machine learning-based prediction models did not outperform the International IgA Nephropathy Prediction Tool

Sehoon Park, Yisak Kim, Chung Hee Baek et al. · 2025 · Kidney Research and Clinical Practice

Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using…

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