Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
杨江胜，朱祖福，高志强，陆强彬，周国庆，方琪 · 2018 · Zhongguo cuzhong zazhi
目的 探讨高龄轻型缺血性卒中3 h内行阿替普酶静脉溶栓治疗的疗效及安全性。 方法 将我院2015年10月-2017年10月连续收治入院的发病3 h内48例高龄急性轻型缺血性卒中患者 随机分为阿替普酶静脉溶栓组24例和未溶栓组24例。比较两组患者入院时的一般情况，基线美国 国立卫生研究院卒中量表（National Institutes of Health Stroke Scale，NHISS）评分，治疗24 h后颅内出 血转化率，治疗后90 d改良Rankin量表（modified Rankin Scale，mRS）评分及90 d病死率。 结果 阿替普酶静脉溶栓组和未溶栓组患者一般临床资料、基线NIHSS评分比较，差异无统计学意 义。阿替普酶静脉溶栓组和未溶栓组治疗24 h后颅内出血转化率分别为4.17%和0（P =1.000），两组 90 d病死率均为4.17%（P =1.000），阿替普酶静脉溶栓组及未溶栓组90 d mRS评分为0～2分的比率 分别为83.33%和54.17%（P =0.029）。 结论 早期阿替普酶静脉溶栓治疗高龄急性轻型缺血性卒中不增加急性期颅内出血转化的风险， 可以改善高龄轻型缺血性卒中患者预后，不增加病死率。 Abstract: Objective To investigate the efficacy and safety of alteplase i
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yuan-yuan LU, Xu-tong ZHAO, Qing-qing WANG et al. · 2018 · Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the mitochondrial DNA (mtDNA) mutation load in hair follicles from different scalp regions of patients with mitochondrial, encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), compare the mutation load in different scalp regions, and analyze the difference in mutation load between scalp regions with lesion site in the brain and scalp regions without lesion site in the brain. Methods Seven MELAS patients with m.3243A > G mutations were studied. Hair follicles were obtained from 8 scalp regions (bilateral frontal, temporal, parietal and occipital lobe
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Adam J.O. Dede, Wenyi Xiao, Nemanja Vaci et al. · 2025 · Molecular Autism
Abstract Background Autism is a complex neurodevelopmental condition, the precise neurobiological underpinnings of which remain elusive. Here, we focus on group differences in resting state EEG (rsEEG). Although many previous reports have pointed to differences between autistic and neurotypical participants in rsEEG, results have failed to replicate, sample sizes have typically been small, and only a small number of variables are reported in each study. Methods Here, we combined five datasets to create a large sample of autistic and neurotypical individuals (n = 776) and extracted 726 variable
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