The m.3243A > G mutation load in hair follicles from different scalp regions of patients with MELAS
Yuan-yuan LU; Xu-tong ZHAO; Qing-qing WANG; Xiao ZHANG; Yun YUAN; Zhao-xia WANG · 2018 · Chinese Journal of Contemporary Neurology and Neurosurgery
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Abstract
Objective To investigate the mitochondrial DNA (mtDNA) mutation load in hair follicles from different scalp regions of patients with mitochondrial, encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), compare the mutation load in different scalp regions, and analyze the difference in mutation load between scalp regions with lesion site in the brain and scalp regions without lesion site in the brain. Methods Seven MELAS patients with m.3243A > G mutations were studied. Hair follicles were obtained from 8 scalp regions (bilateral frontal, temporal, parietal and occipital lobe
Abstract by Yuan-yuan LU; Xu-tong ZHAO; Qing-qing WANG; Xiao ZHANG; Yun YUAN; Zhao-xia WANG, Chinese Journal of Contemporary Neurology and Neurosurgery (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3969/j.issn.1672-6731.2018.08.004