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Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Longitudinal Reliability of Rheumatology Patient Safety Measures and Implications for CMS Case Minimums.

Roberts ET, Schmajuk G, Fitzpatrick J et al. · 2026 · Joint Commission journal on quality and patient safety

Background Metrics with acceptable reliability are necessary to ensure that quality measures reward performance. Low metric reliability may result from a lack of differences between reporting entities or low numbers of eligible patients.…

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Negative / Null Result ReportOpen accessMedicine

Long-term changes in overjet in individuals with and without orthodontic treatment : A 30-year cohort study.

Bokan J, Schmid JQ, Middelberg C et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie

Purpose Large overjet increases the risk of traumatic dental injury (TDI). This study, part of the Münster Long-Term Study (MLS), aimed to investigate long-term changes in overjet with or without orthodontic treatment and to evaluate…

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Negative / Null Result ReportMedicine

High-flow nasal cannula improves pulmonary gas exchange during endoscopic retrograde cholangiopancreatography: A single-center randomized controlled trial.

Martínez-Ocón J, Pérez M, Calvo A et al. · 2026 · Journal of clinical anesthesia

Background Sedation during endoscopic retrograde cholangiopancreatography procedures (ERCP) increases the risk of hypoxemia and the need for respiratory support in high-risk patients. High flow nasal cannula (HFNC) provides humidified gas…

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Negative / Null Result ReportMedicine

Use of Virtual Reality for Pain Relief During Cervical Conization Under Local Anesthesia: A Randomized Controlled Trial.

Michaan N, Michaan N, Laskov I et al. · 2026 · Journal of lower genital tract disease

Objectives Cervical conization (loop electrosurgical excision procedure) under local anesthesia is often associated with anxiety and procedural pain. Virtual reality (VR) glasses may enhance patient experience and reduce discomfort during…

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Negative / Null Result ReportMedicine

Incidence, Predictors, and Outcomes of Stroke Following Transcatheter Aortic Valve Implantation: A Multicenter Australian Experience.

Butala AD, Nanayakkara S, Johnston R et al. · 2026 · The American journal of cardiology

Stroke is a serious complication following transcatheter aortic valve implantation, associated with increased disability and mortality. Despite this, there is a lack of patient-level data examining stroke in contemporary, lower-risk…

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Negative / Null Result ReportMedicine

Letter to the Editor: Comment on Adamovich-Zeitlina et al's "Clinical Outcomes of Boston Type 1 Keratoprosthesis With and Without Endophthalmitis During the Covid-19 Pandemic".

Geoffrion D, Mikhail D, Rizk M et al. · 2025 · Ocular immunology and inflammation

Authors reported an 18% rate of endophthalmitis in Boston type 1 keratoprosthesis (KPro) patients, higher than previously reported rates. Most cases occurred during the COVID-19 pandemic, likely due to reduced access to care. Bandage…

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Negative / Null Result ReportMedicine

Maladaptive Trained Immunity Drives Persistent IL-6 Production and Enhanced TLR Responsiveness in Monocyte-Derived Macrophages from People Living with HIV.

Dubrovsky L, Pushkarsky T, Brichacek B et al. · 2026 · Microorganisms

Trained immunity (TRIM) enhances innate immune responses through epigenetic and metabolic reprogramming but may become maladaptive, contributing to chronic inflammation. In people living with HIV (PLWH), maladaptive TRIM has been proposed…

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Negative / Null Result ReportMedicine

Combined Propofol and Dexmedetomidine Is Associated with Lower Mortality but Not Delirium After Cardiovascular Surgery: A Retrospective Cohort Study Using an Administrative Claims Database.

Tamoto M, Kai S, Yoshida H et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives To compare the real-world effectiveness of combined propofol and dexmedetomidine (PRODEX) sedation with propofol monotherapy on survival and postoperative delirium (POD) in a large nationwide cohort of patients undergoing…

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Negative / Null Result ReportMedicine

Reducing Household Tuberculosis Transmission: A Pilot Cluster-Randomized Controlled Trial.

Ruiz-Tagle C, Seguel R, Villarroel L et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce…

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Negative / Null Result ReportMedicine

Clinical impact of enhanced recovery after spinal surgery protocols on one-level lumbar arthrodesis: results from a single-center randomized controlled trial.

Kashtiara A, Pauptit J, Thijs D et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Objectives Enhanced Recovery After Surgery (ERAS) protocols aim to improve surgical outcomes, by mitigating postoperative stress through multimodal perioperative care. In spinal surgery, such protocols may reduce pain, hospital length of…

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Negative / Null Result ReportOpen accessMedicine

Experience over tools: does the use of magnifying loupes reduce the incidence of transient postoperative hypocalcemia after total thyroidectomy with central neck dissection? - a single-centre prospective randomized study.

Sielski W, Osęka T, Antolak A et al. · 2026 · Frontiers in endocrinology

Background Parathyroid preservation during total thyroidectomy with central neck dissection in papillary thyroid carcinoma remains challenging due to the glands' delicate vascular anatomy and risk of inadvertent devascularization or…

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