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WASTE Journal

Browse the failure-mode index

12,241 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effect of Extended Dual Antiplatelet Therapy on the Prognosis of Patients With ST Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Cohort Study.

Li YC, Wang JY, Lei MJ et al. · 2026 · Health science reports

Background and aims To inquire the effect of extending the duration of dual antiplatelet therapy (DAPT) to 18-24 months on the prognosis of patients with ST segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary…

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Negative / Null Result ReportMedicine

Enhancing Removable Partial Denture Hygiene: Investigating Mucolytic Agents and Biocides for Disrupting Biofilms and Improving Antimicrobial Efficacy.

Moraes LGDS, Oliveira VC, Macedo AP et al. · 2025 · The International journal of prosthodontics

Purpose To evaluate the antibiofilm action of 2.5 mg/mL peracetic acid (PA), 0.5 mg/mL cetylpyridinium chloride (CPC), and 160 mg/mL N-acetylcysteine (NAC) against multispecies biofilm of Streptococcus mutans, Staphylococcus aureus,…

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Negative / Null Result ReportOpen accessMedicine

Effect of virtual reality distraction on anxiety, pain and discomfort during unsedated gastroscopy: Randomized controlled trial.

Bouman Z, De Vries F, De Ruiter M et al. · 2026 · Endoscopy international open

Background and study aims Esophagogastroduodenoscopy is a widely used medical examination. Despite the short duration of this procedure, many patients experience anxiety, pain, and discomfort. The aim of this study was to examine effects…

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Negative / Null Result ReportMedicine

Hyaluronidase activity of Indian ornamental tarantula (Poecilotheria regalis) venom is significantly reduced by commercial Latrodectus mactans and American scorpion antivenoms.

García-García M, Mosqueda J, Escobar-Cabrera JE et al. · 2025 · Toxicon : official journal of the International Society on Toxinology

A recent clinical case involving a Poecilotheria regalis bite was treated with Mexican L. mactans antivenom (Aracmyn Plus, Silanes, Mexico), resulting in the improvement of some of the symptoms. This could be attributed to cross-reactivity…

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Negative / Null Result ReportMedicine

Assessing the Comparative Ability of Early Postoperative T4-L1PA Mismatch versus L1PA or T4PA Alone for Predicting Mechanical Complications or Spinal Reoperations: A Retrospective Analysis.

Baumann AN, Chatzis K, Son E et al. · 2026 · Spine

Study design Retrospective single-center study. Objective We aim to compare the prognostic capacity of postoperative T4-L1PA mismatch versus T4PA and L1PA alone. Summary of background data The assessment of T4-L1PA mismatch, the difference…

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Negative / Null Result ReportMedicine

Optimizing a Multimodal Large Language Model for Ultrasound-Based Thyroid Nodule Malignancy Classification: A Comparative Study of Few-Shot Learning, Prompt Engineering, and Fine-Tuning.

Li YH, Cheng YC, Chang CY et al. · 2026 · Diagnostics (Basel, Switzerland)

Objectives: Multimodal large language models (MLLMs) have shown potential for medical image classification. We evaluated four optimization strategies in two MLLMs-GPT-4o (gpt-4o-2024-08-06) and Gemini 2.5 Flash-Lite-for ultrasound-based…

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Negative / Null Result ReportMedicine

Effects of high- versus moderate-intensity multimodal whole-body training to improve inspiratory muscle function in persons with chronic nonspecific low back pain.

Klaps S, Verbrugghe J, Goossens N et al. · 2026 · BMC sports science, medicine & rehabilitation

Background To compare the effects of a multimodal whole-body high-intensity training (HIT) program versus a moderate-intensity training (MIT) program on inspiratory muscle function in persons with chronic nonspecific low back pain…

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Negative / Null Result ReportMedicine

Effects of quercetin supplementation in aging mice on oocyte number, in vitro fertilization and embryo development outcomes.

Wisetmongkolchai T, Somboonchai P, Piromlertamorn W et al. · 2026 · JBRA assisted reproduction

Objective To investigate the effects of quercetin supplementation in aging mice on the oocyte number and in vitro fertilization outcomes. Methods Thirty-two to forty-week-old aging female mice were randomly assigned into two groups, with…

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Negative / Null Result ReportMedicine

Safety, tolerability, and efficacy of acetazolamide in idiopathic normal pressure hydrocephalus (DRAIN) in Sweden: a randomised, double-blind, placebo-controlled, phase 2 trial.

Virhammar J, Fasth O, Ekblom M et al. · 2026 · The Lancet. Neurology

Background Idiopathic normal pressure hydrocephalus is a potentially reversible cause of gait disturbance, cognitive impairment, and urinary incontinence, typically in adults aged 60 years or older. Ventriculoperitoneal shunt surgery…

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Negative / Null Result ReportMedicine

A Randomized, Double-Blind, Pilot Study of N-Acetylcysteine for Motor and Cognitive Symptoms in Youth With Neurofibromatosis Type 1.

Gilbert DL, Aschbacher-Smith LE, Migneault KY et al. · 2026 · Pediatric neurology

Background Children and youth with neurofibromatosis type 1 (NF1) commonly experience motor, behavioral, and cognitive problems. Promising findings from an NF1 mouse model suggested that the antioxidant N-acetylcysteine (NAC) might address…

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Negative / Null Result ReportMedicine

Offloading reduces prospective memory learning.

Fellers C, Storm BC · 2026 · Journal of experimental psychology. Learning, memory, and cognition

Across two experiments, we investigated the effects of cognitive offloading on prospective memory (PM). Participants performed two PM tasks, either relying on internal memory for both (Dual PM condition) or using an external reminder for…

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Negative / Null Result ReportMedicine

Automated perfusion imaging did not improve reliability of ASPECTS or collateral score in late-window large vessel occlusion stroke.

Benomar A, Fahed R, Omar AT et al. · 2026 · Journal of neurointerventional surgery

Background The Alberta Stroke Program Early CT Score (ASPECTS) and CT angiography (CTA) Collateral Score (CS) are routinely used to estimate ischemic core burden and collateral status in acute ischemic stroke due to large vessel occlusion,…

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Negative / Null Result ReportMedicine

Can the Social Vulnerability Index Enhance Models Predicting Adherence to Craniofacial Speech Evaluations?

Kong BH, Dillon K, Brady CM et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo determine whether the Centers for Disease Control and Prevention's Social Vulnerability Index (SVI) influences models of adherence to speech evaluations beyond individual demographic and clinical factors.DesignRetrospective…

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Negative / Null Result ReportMedicine

Effects of Ultra-short Offline States on Item-level Verbal Memory.

Wamsley EJ, Barron J, Livingston WH · 2026 · Journal of cognitive neuroscience

Memory is consolidated during "offline" states of reduced attention to the external stimulus environment, including sleep and resting wakefulness. While consolidation is usually studied on a timescale of hours to days, accumulating…

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Negative / Null Result ReportMedicine

Serum 25-Hydroxyvitamin D Levels did not improve with N-Acetylcysteine administration nor with abstinence in Adults Treated for Alcohol Use Disorder: A Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Piazza FRG, Schuch JB, Ferreira DNSDS et al. · 2025 · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

Objective N-acetylcysteine (NAC) is a medication known for its hepatoprotective properties and potential to reduce cravings and psychoactive substance use. Vitamin D is metabolized in the liver, and individuals with alcohol abuse often…

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Negative / Null Result ReportMedicine

Acute Effect of Thoracic Mobility Exercises on Respiratory Function and Thoracolumbar Mobility in Healthy Adults: A Pilot Crossover Trial.

Leak M, Giambini H, Cheever K et al. · 2026 · Journal of sport rehabilitation

Context Thoracic mobility is integral to respiratory function and mobility of the neck, shoulder, and spine. The efficacy of thoracic mobility exercises in enhancing respiratory function and spinal range of motion (ROM) is well documented…

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