Maladaptive Trained Immunity Drives Persistent IL-6 Production and Enhanced TLR Responsiveness in Monocyte-Derived Macrophages from People Living with HIV.
Dubrovsky L; Pushkarsky T; Brichacek B; Bastin A; Roberts A; Lucar J; Ruiz ME; Semeniuk O · 2026 · Microorganisms
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Trained immunity (TRIM) enhances innate immune responses through epigenetic and metabolic reprogramming but may become maladaptive, contributing to chronic inflammation. In people living with HIV (PLWH), maladaptive TRIM has been proposed…
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Metadata source: Europe PMC · DOI 10.3390/microorganisms14020355