Combined Propofol and Dexmedetomidine Is Associated with Lower Mortality but Not Delirium After Cardiovascular Surgery: A Retrospective Cohort Study Using an Administrative Claims Database.
Tamoto M; Kai S; Yoshida H; Shintani A · 2026 · Journal of cardiothoracic and vascular anesthesia
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Objectives To compare the real-world effectiveness of combined propofol and dexmedetomidine (PRODEX) sedation with propofol monotherapy on survival and postoperative delirium (POD) in a large nationwide cohort of patients undergoing…
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Metadata source: Europe PMC · DOI 10.1053/j.jvca.2025.11.037