Negative / Null Result ReportMedicine
Mats Brittberg, David P. Recker, John Ilgenfritz et al. · 2018 · The American Journal of Sports Medicine
Background: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured…
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Mark van den Boogaard, Arjen J. C. Slooter, Roger J. M. Brüggemann et al. · 2018 · JAMA
Importance: Results of studies on use of prophylactic haloperidol in critically ill adults are inconclusive, especially in patients at high risk of delirium. Objective: To determine whether prophylactic use of haloperidol improves survival…
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Simon Finfer, Sharon Micallef, Naomi Hammond et al. · 2022 · New England Journal of Medicine
BACKGROUND: Whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney injury or death is uncertain. METHODS: In a…
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Anup Katheria, Frank Reister, Jochen Essers et al. · 2019 · JAMA
Importance: Umbilical cord milking as an alternative to delayed umbilical cord clamping may provide equivalent benefits to preterm infants, but without delaying resuscitation. Objective: To determine whether the rates of death or severe…
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Markus Gschwind, Gilles Pourtois, Sophie Schwartz et al. · 2011 · Cerebral Cortex
Face recognition is of major social importance and involves highly selective brain regions thought to be organized in a distributed functional network. However, the exact architecture of interconnections between these regions remains…
View details →Negative / Null Result ReportOpen accessMedicine
Cindy Van Humbeeck, Tom Cornelissen, Hilde Hofkens et al. · 2011 · Journal of Neuroscience
Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy).…
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Philippe Bégin, Jeannie Callum, Erin Jamula et al. · 2021 · Nature Medicine
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 d of respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml of convalescent plasma or standard of care. The composite primary outcome was intubation or death by 30 d. Exploratory analyses
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James D. A. Parker, Graeme J. Taylor, Michael Bagby · 2010 · Psychotherapy and Psychosomatics
Slides of photographs depicting posed facial expressions of nine different emotions were presented to 131 females and 85 males who were asked to identify the emotion(s) being experienced by the person in each photograph. Subjects were then…
View details →Negative / Null Result ReportMedicine
Stefan Lohmander, Scarlett Hellot, Don Dreher et al. · 2014 · Arthritis & Rheumatology
OBJECTIVE: To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). METHODS: The study was a randomized, double-blind,…
View details →Negative / Null Result ReportMedicine
Steven T. Lanier, Eric D. Wang, John J. Chen et al. · 2010 · Annals of Plastic Surgery
Tissue expander/implant breast reconstructions by 5 surgeons at a single institution from 2005 to 2008 were retrospectively identified and divided into 2 cohorts: use of acellular dermal matrix (ADM, n = 75) versus standard submuscular…
View details →Negative / Null Result ReportOpen accessMedicine
Atthaphorn Trakarnsanga, Mithat Gönen, Jinru Shia et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Tumor regression grade (TRG) is a measure of histopathological response of rectal cancer to neoadjuvant chemoradiation and is associated with outcomes. Several TRG systems are used: Mandard (5,3-tier), Dowrak/Rödel (5,3-tier),…
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Taofeek K. Owonikoko, Keunchil Park, Ramaswamy Govindan et al. · 2021 · Journal of Clinical Oncology
PURPOSE: In extensive-disease small-cell lung cancer (ED-SCLC), response rates to first-line platinum-based chemotherapy are robust, but responses lack durability. CheckMate 451, a double-blind phase III trial, evaluated nivolumab plus…
View details →Negative / Null Result ReportOpen accessMedicine
Kaitlin B. Casaletto, Anya Umlauf, Jennifer L. Beaumont et al. · 2015 · Journal of the International Neuropsychological Society
Demographic factors impact neuropsychological test performances and accounting for them may help to better elucidate current brain functioning. The NIH Toolbox Cognition Battery (NIHTB-CB) is a novel neuropsychological tool, yet the…
View details →Negative / Null Result ReportOpen accessMedicine
Gus A. Baker, Rebecca Bromley, Maria Briggs et al. · 2014 · Neurology
OBJECTIVE: To delineate the risk to child IQ associated with frequently prescribed antiepileptic drugs. METHODS: Children born to women with epilepsy (n = 243) and women without epilepsy (n = 287) were recruited during pregnancy and…
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Marianna Fontana, Steve K White, Sanjay M Banypersad et al. · 2012 · Journal of Cardiovascular Magnetic Resonance
BACKGROUND: Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium. Equilibrium CMR (EQ-CMR), using a bolus-infusion protocol, has been shown to provide robust measurements of ECV using a multibreath-hold T1 pulse sequence. Newer, faster sequences for T1 mapping promise whole heart coverage and improved clinical utility, but have not been validated. METHODS: Multibreathhold T1 quantification with heart rate correction and single breath-hold T1 mapping using
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Didier Keh, Evelyn Trips, Gernot Marx et al. · 2016 · JAMA
Importance: Adjunctive hydrocortisone therapy is suggested by the Surviving Sepsis Campaign in refractory septic shock only. The efficacy of hydrocortisone in patients with severe sepsis without shock remains controversial. Objective: To…
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Ludmila Danilova, Won Jin Ho, Qingfeng Zhu et al. · 2019 · Cancer Immunology Research
Abstract Immune-checkpoint therapy has failed to demonstrate meaningful clinical benefit in unselected cases of pancreatic adenocarcinoma (PDAC), but a subset of PDACs are known to upregulate pathways involved in acquired immune…
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C. Schilder, Caroline Seynaeve, L.V.A.M. Beex et al. · 2010 · Journal of Clinical Oncology
PURPOSE: To evaluate the influence of adjuvant tamoxifen and exemestane on cognitive functioning in postmenopausal patients with breast cancer (BC). PATIENTS AND METHODS: Neuropsychological assessments were performed before the start (T1)…
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Giorgio V. Scagliotti, Joachim von Pawel, Silvia Novello et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Tivantinib, a MET receptor tyrosine kinase inhibitor, demonstrated increased anticancer activity in preclinical and early clinical studies when combined with erlotinib. Our study aimed to confirm efficacy and safety of the…
View details →Negative / Null Result ReportOpen accessMedicine
US Preventive Services Task Force, Kirsten Bibbins‐Domingo, David C. Grossman et al. · 2017 · JAMA
IMPORTANCE: Preeclampsia affects approximately 4% of pregnancies in the United States. It is the second leading cause of maternal mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and organ…
View details →Negative / Null Result ReportOpen accessMedicine
Corita R. Grudzen, Lynne D. Richardson, Pauline N. Johnson et al. · 2016 · JAMA Oncology
IMPORTANCE: The delivery of palliative care is not standard of care within most emergency departments (EDs). OBJECTIVE: To compare quality of life, depression, health care utilization, and survival in ED patients with advanced cancer…
View details →Negative / Null Result ReportMedicine
Shitao Rao, Alexandria Lau, Hon‐Cheong So · 2020 · Diabetes Care
OBJECTIVE COVID-19 has become a major public health problem. There is good evidence that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase susceptibility to infection. We aimed to explore risk factors affecting…
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Margie E. Lachman, Stefan Agrigoroaei, Patricia A. Tun et al. · 2013 · Assessment
Assessment of cognitive functioning is an important component of telephone surveys of health. Previous cognitive telephone batteries have been limited in scope with a primary focus on dementia screening. The Brief Test of Adult Cognition…
View details →Negative / Null Result ReportOpen accessMedicine
Carole Clair, Nancy A. Rigotti, Bianca Porneala et al. · 2013 · JAMA
IMPORTANCE: Smoking cessation reduces the risks of cardiovascular disease (CVD), but weight gain that follows quitting smoking may weaken the CVD benefit of quitting. OBJECTIVE: To test the hypothesis that weight gain following smoking…
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Bharat Randive, Vishal Diwan, Ayesha De Costa · 2013 · PLoS ONE
BACKGROUND: India accounts for 19% of global maternal deaths, three-quarters of which come from nine states. In 2005, India launched a conditional cash transfer (CCT) programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality ratio (MMR) through promotion of institutional births. JSY is the largest CCT in the world. In the nine states with relatively lower socioeconomic levels, JSY provides a cash incentive to all women on birthing in health institution. The cash incentive is intended to reduce financial barriers to accessing institutional care for delivery. Increased institutional
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Yuhei Kobayashi, Hiroyuki Okura, Teruyoshi Kume et al. · 2014 · Circulation Journal
BACKGROUND: Stent underexpansion remains a concern as a cause of drug-eluting stent (DES) failure. Although coronary calcification is considered to be a contributing factor in stent underexpansion, previous intravascular ultrasound studies…
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Haresh Kirpalani, Edward F. Bell, Susan R. Hintz et al. · 2020 · New England Journal of Medicine
BACKGROUND: Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia. METHODS: We performed an open, multicenter trial in…
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Lyna Z. Schieber, Gery P. Guy, Puja Seth et al. · 2019 · JAMA Network Open
Importance: Risk of opioid use disorder, overdose, and death from prescription opioids increases as dosage, duration, and use of extended-release and long-acting formulations increase. States are well suited to respond to the opioid crisis through legislation, regulations, enforcement, surveillance, and other interventions. Objective: To estimate temporal trends and geographic variations in 6 key opioid prescribing measures in 50 US states and the District of Columbia. Design, Setting, and Participants: Population-based cross-sectional analysis of opioid prescriptions filled nationwide at US r
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Elizabeth DiNenno, Joseph Prejean, Kathleen L. Irwin et al. · 2017 · MMWR Morbidity and Mortality Weekly Report
CDC's 2006 recommendations for human immunodeficiency virus (HIV) testing state that all persons aged 13-64 years should be screened for HIV at least once, and that persons at higher risk for HIV infection, including sexually active gay,…
View details →Negative / Null Result ReportMedicine
Jane W. Newburger, Lynn A. Sleeper, J. William Gaynor et al. · 2018 · Circulation
Background: In the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for the Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared with a modified Blalock–Taussig shunt in…
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