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WASTE Journal

Browse the failure-mode index

12,241 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Increasing Facial Attractiveness by Lateralizing the Auricle-Analyzing the Pan-Facial Effects of the Postauricular Injection Technique in Chinese Patient Populations.

Hong WJ, Huang JM, Liu YH et al. · 2025 · Aesthetic plastic surgery

Background The postauricular injection technique is a needle-based technique that places soft tissue fillers behind the ears into the supra-periosteal plane of the mastoid process of the temporal bone. The resulting clinical effect pushes…

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Negative / Null Result ReportMedicine

The impact of total laparoscopic excision of deep endometriosis (DE) on bladder and bowel dysfunction: a prospective longitudinal study.

Morris JS, Rajshekhar S, Gremmo G et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Deep endometriosis (DE) is established to cause chronic pelvic pain (CPP), lower urinary tract symptoms (LUTS) and altered bowel function. Although the aim of surgical excision is often to relieve CPP, evidence suggests it could also…

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Negative / Null Result ReportOpen accessMedicine

Molecular imaging of lymphatic organs provides prognostic value after acute myocardial infarction.

Reiter T, Dörrler AL, Hasenauer N et al. · 2026 · European journal of nuclear medicine and molecular imaging

Introduction Acute myocardial infarction (AMI) triggers local inflammation in the injured myocardium, followed by a systemic inflammatory response of lymphatic organs. This prospective trial (NCT05519735) focused on molecular imaging of…

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Negative / Null Result ReportMedicine

Effects of heat stress on human health and physio-biochemical attributes of quinoa growing in arsenic contaminated soil.

Shabbir A, Abbas G, Alharby HF et al. · 2026 · International journal of phytoremediation

Heat stress and soil arsenic (As) contamination are resulting in severe decline in crop production around the world. The present experiment aimed to assess physiological and biochemical changes induced by the combination of As and heat…

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Negative / Null Result ReportMedicine

Evaluation of incisional negative pressure wound therapy with anterior approach total ankle arthroplasty.

Cottom JM, Verdoni TJ · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background Total ankle replacement continues to find significantly increased utilization as the technology advances. While there are different systems on the market, most are implanted through an anterior incisional approach just lateral…

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Negative / Null Result ReportMedicine

Exposure levels and target attainment of meropenem in adult patients admitted to the intensive care unit: a prospective observational study.

El-Haffaf I, Marsot A, Paillault A et al. · 2025 · Canadian journal of physiology and pharmacology

In this study, we evaluate the exposure and pharmacokinetic/pharmacodynamic target attainment of meropenem in critically ill patients. We conducted a prospective observational study in two Canadian intensive care units (ICUs) from January…

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Negative / Null Result ReportOpen accessMedicine

Comment on "A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children".

Wang J · 2025 · Scandinavian journal of trauma, resuscitation and emergency medicine

This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09),…

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Negative / Null Result ReportMedicine

How prior racing performance influences competition level in off-the-track Thoroughbred horses' post-racing eventing careers.

Bacon EK, Parnell D, Muscatello G et al. · 2025 · Journal of equine veterinary science

Background The ongoing discussion surrounding the well-being of retired racehorses underscores the importance of implementing effective rehoming strategies that prioritise animal welfare. A significant knowledge gap persists regarding…

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Negative / Null Result ReportMedicine

Placental morphofunctional adaptations and offspring outcomes after protein restriction before and during pregnancy in mice.

Felicioni F, Nivia-Riveros JA, Caldeira-Brant AL et al. · 2026 · The Journal of nutritional biochemistry

Proper fetal development depends on maternal nutrition. We investigated the placental morphofunctional adaptations to a low-protein diet, and their impact on fetal and newborn outcomes. Swiss mice were fed either normal (NPD, 20% crude…

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Negative / Null Result ReportMedicine

Conventional Cytogenetic Analysis of Constitutional Abnormalities: A 20-Year Review of Proficiency Test Results From the College of American Pathologists/American College of Medical Genetics and Genomics Cytogenetics Committee.

Boles B, Gardner JA, Rehder CW et al. · 2025 · Archives of pathology & laboratory medicine

Context.— The joint College of American Pathologists/American College of Medical Genetics and Genomics Cytogenetics Committee works to ensure competency and proficiency of clinical cytogenetics testing laboratories through proficiency…

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Negative / Null Result ReportOpen accessMedicine

Comparing a Conceptual Framework and Factor Analysis to Achieve Survey Item Reduction in Predicting Medication Non-Persistence.

Umeaghadi CF, Taylor JG, Yao S et al. · 2026 · Patient preference and adherence

Adherence surveys can be lengthy due to the high number of potential risk factors to be analyzed. As a result, researchers often reduce items into conceptual domains (eg, beliefs, economic factors) to overcome power constraints or focus…

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Negative / Null Result ReportMedicine

Acceptability of Adolescent Portal Access Policies to Parents and Adolescents: A Delphi Study.

Sisk BA, Antes AL, Bereitschaft C et al. · 2025 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Purpose United States healthcare systems have enacted varied adolescent online patient portal policies. No prior work has established whether these policies are acceptable to adolescents and parents. Methods Mixed-method Delphi approach…

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Negative / Null Result ReportOpen accessMedicine

Safety Audit of a Large Language Model for Lay Self-Triage Using Japanese Symptom Vignettes: Persistent Red-Flag Under-Triage Despite Improved Reproducibility Under Near-Deterministic Decoding.

Harada Y · 2026 · Cureus

Introduction Large language models are increasingly discussed as tools for patient-facing symptom assessment, but safe self-triage depends on the concrete next action recommended to the user rather than on generic urgency language alone.…

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Negative / Null Result ReportMedicine

The State of Surgery in Botswana, 2018 to 2022.

Romeo DJ, Wagner CS, Ahluwalia V et al. · 2025 · The Journal of craniofacial surgery

Many people living in low-income and middle-income countries (LMICs) lack access to safe surgical and anesthetic care. The Lancet Commission on Global Surgery (LCGS) recommended that all countries track surgical volume and target 5,000…

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Negative / Null Result ReportMedicine

Factors associated with failure to achieve Scoliosis Research Society-22r minimal clinically important difference despite achieving optimal global alignment in adult spinal deformity surgery.

Park SJ, Park JS, Kang DH et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To identify factors associated with failure to achieve the minimal clinically important difference (MCID) in the Scoliosis Research Society-22r (SRS-22r) despite achieving optimal global alignment in adult spinal deformity (ASD)…

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Negative / Null Result ReportOpen accessMedicine

Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery.

Drew RH, Turner NA, Keil E et al. · 2026 · Infection control and hospital epidemiology

In a propensity-matched cohort of adult cardiac or neurosurgical procedures ( n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically…

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Negative / Null Result ReportMedicine

Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry.

Schmitt A, Behnes M, Bertsch T et al. · 2025 · European journal of internal medicine

Background Elevated uric acid (UA) is a recognized biomarker in patients with cardiovascular disease. However, the prognostic significance of UA levels in patients with heart failure (HF), particularly those with HF with mildly reduced…

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Negative / Null Result ReportMedicine

Vaccine hesitancy among nurses in the Marche Region.

Fortunato C, Gasperini B, Mengarelli Rinaldini D et al. · 2025 · Annali di igiene : medicina preventiva e di comunita

Background Vaccine hesitancy is considered one of the top ten threats to global health by the World Health Organization due to the potential public health consequences. Since April 1, 2021, the Italian Government has made COVID-19…

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Negative / Null Result ReportOpen accessMedicine

A randomised, double-blind, placebo-controlled trial to assess the postprandial dose-dependent effects of wild blueberries on metabolic and cognitive outcomes following a high-carbohydrate breakfast.

Ellis LR, O'Connor D, Khan H et al. · 2026 · European journal of nutrition

Purpose Despite equivocal human study data, anthocyanin-rich blueberries are associated with positive glycaemic effects which could benefit satiety and other cardiometabolic outcomes. The objective of this study was to examine the…

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