Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery
Dirisala A; Uchida S; Toh K; Li J; Liu X; Wen P; Fukushima S; Kataoka K · 2025 · Journal of Controlled Release
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Polycation-based mRNA delivery systems have an issue with mRNA integrity in the physiological milieu, particularly in blood compartments, despite their vast potential in mRNA therapeutics. Without comprehensive mechanistic analyses, design…
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Metadata source: Europe PMC