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WASTE Journal

Browse the failure-mode index

12,218 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Randomized Phase III Trial of Induction Chemotherapy With Docetaxel, Cisplatin, and Fluorouracil Followed by Surgery Versus Up-Front Surgery in Locally Advanced Resectable Oral Squamous Cell Carcinoma

Lai-ping Zhong, Chen-ping Zhang, Guo-xin Ren et al. · 2012 · Journal of Clinical Oncology

PURPOSE: To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced…

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Negative / Null Result ReportOpen accessMedicine

Phase III Trial of Prophylactic Cranial Irradiation Compared With Observation in Patients With Locally Advanced Non–Small-Cell Lung Cancer: Neurocognitive and Quality-of-Life Analysis

A. Sun, Kyounghwa Bae, Elizabeth Gore et al. · 2010 · Journal of Clinical Oncology

PURPOSE: There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and quality of life (QOL). Radiation Therapy Oncology Group trial 0214 showed no overall survival (OS) benefit…

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Negative / Null Result ReportOpen accessMedicine

Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms

Cornelis Blauwendraat, Karl Heilbron, Costanza L. Vallerga et al. · 2019 · Movement Disorders

BACKGROUND: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants…

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Negative / Null Result ReportOpen accessMedicine

Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group

Danny Rischin, Lester J. Peters, Brian O’Sullivan et al. · 2010 · Journal of Clinical Oncology

PURPOSE: Promising results in a randomized phase II trial with the hypoxic cytotoxin tirapazamine (TPZ) combined with cisplatin (CIS) and radiation led to this phase III trial. PATIENTS AND METHODS: Patients with previously untreated stage…

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Negative / Null Result ReportMedicine

Increasing incidence of acute Achilles tendon rupture and a noticeable decline in surgical treatment from 1994 to 2013. A nationwide registry study of 33,160 patients

Ann Ganestam, Thomas Kallemose, Anders Troelsen et al. · 2015 · Knee Surgery Sports Traumatology Arthroscopy

The purpose of this study is to investigate the incidence of acute Achilles tendon rupture in Denmark from 1994 to 2013 with focus on sex, age, geographical areas, seasonal variation and choice of treatment. The National Patient Registry…

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Negative / Null Result ReportOpen accessMedicine

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential

May Al-Nbaheen, Radhakrishnan Vishnubalaji, Dalia Ali et al. · 2012 · Stem Cell Reviews and Reports

Human stromal (mesenchymal) stem cells (hMSCs) are multipotent stem cells with ability to differentiate into mesoderm-type cells e.g. osteoblasts and adipocytes and thus they are being introduced into clinical trials for tissue regeneration. Traditionally, hMSCs have been isolated from bone marrow, but the number of cells obtained is limited. Here, we compared the MSC-like cell populations, obtained from alternative sources for MSC: adipose tissue and skin, with the standard phenotype of human bone marrow MSC (BM-MSCs). MSC from human adipose tissue (human adipose stromal cells (hATSCs)) and h

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Negative / Null Result ReportMedicine

Assessment of Quality Outcomes for Robotic Pancreaticoduodenectomy

Brian A. Boone, Mazen S. Zenati, Melissa E. Hogg et al. · 2015 · JAMA Surgery

IMPORTANCE: Quality assessment is an important instrument to ensure optimal surgical outcomes, particularly during the adoption of new surgical technology. The use of the robotic platform for complex pancreatic resections, such as the…

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Negative / Null Result ReportOpen accessMedicine

Treatment of Multisystem Inflammatory Syndrome in Children

Andrew McArdle, Ortensia Vito, Harsita Patel et al. · 2021 · New England Journal of Medicine

BACKGROUND: Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS: We performed an international…

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Negative / Null Result ReportMedicine

Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial*

Jens‐Ulrik Stæhr Jensen, Lars Hein, Bettina Lundgren et al. · 2011 · Critical Care Medicine

OBJECTIVE: For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis. The objective of this trial was to determine whether a…

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Negative / Null Result ReportOpen accessMedicine

The Relationship Between Diabetes Distress and Clinical Depression With Glycemic Control Among Patients With Type 2 Diabetes

Lawrence Fisher, Russell E. Glasgow, Lisa A. Strycker · 2010 · Diabetes Care

OBJECTIVE: To clarify previous findings that diabetes distress is related to glycemic control and self-management whereas measures of depression are not, using both binary and continuous measures of depression. RESEARCH DESIGN AND METHODS:…

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Negative / Null Result ReportOpen accessMedicine

Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

Alessandro Doria, Andrzej T. Gałecki, Cathie Spino et al. · 2020 · New England Journal of Medicine

BACKGROUND: Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration rate (GFR) in persons with type 1…

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Negative / Null Result ReportOpen accessMedicine

Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding

James Y. Lau, Yuanyuan Yu, Raymond S. Tang et al. · 2020 · New England Journal of Medicine

BACKGROUND: It is recommended that patients with acute upper gastrointestinal bleeding undergo endoscopy within 24 hours after gastroenterologic consultation. The role of endoscopy performed within time frames shorter than 24 hours has not…

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Negative / Null Result ReportMedicine

Platelet-Rich Plasma Versus Autologous Whole Blood for the Treatment of Chronic Lateral Elbow Epicondylitis

C. Thanasas, George N. Papadimitriou, Charalambos Charalambidis et al. · 2011 · The American Journal of Sports Medicine

BACKGROUND: Chronic lateral elbow epicondylitis is a tendinosis with angiofibrolastic degeneration of the wrist extensors' origin. Healing of this lesion is reported with the use of autologous blood as well as with platelet-rich plasma…

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Negative / Null Result ReportMedicine

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

Joeli Marrero, Kyu Y. Rhee, Dirk Schnappinger et al. · 2010 · Proceedings of the National Academy of Sciences

Metabolic adaptation to the host niche is a defining feature of the pathogenicity of Mycobacterium tuberculosis (Mtb). In vitro, Mtb is able to grow on a variety of carbon sources, but mounting evidence has implicated fatty acids as the…

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Negative / Null Result ReportOpen accessMedicine

A survey on the attitudes towards research in medical school

D. Robert Siemens, Sanoj Punnen, James M.W. Wong et al. · 2010 · BMC Medical Education

BACKGROUND: An observed decrease of physician scientists in medical practice has generated much recent interest in increasing the exposure of research programs in medical school. The aim of this study was to review the experience and attitudes regarding research by medical students in Canada. METHODS: An anonymous, cross-sectional, self-report questionnaire was administered to second and fourth year students in three medical schools in Ontario between February and May of 2005. Questions were primarily closed-ended and consisted of Likert scales. Descriptive and correlative statistics were used

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Negative / Null Result ReportOpen accessMedicine

The Barrow Ruptured Aneurysm Trial: 3-year results

Robert F. Spetzler, Cameron G. McDougall, Felipe C Albuquerque et al. · 2013 · Journal of neurosurgery

OBJECT: The authors report the 3-year results of the Barrow Ruptured Aneurysm Trial (BRAT). The objective of this ongoing randomized trial is to compare the safety and efficacy of microsurgical clip occlusion and endovascular coil…

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Negative / Null Result ReportOpen accessMedicine

Randomized Phase III Trial of Amrubicin Versus Topotecan As Second-Line Treatment for Patients With Small-Cell Lung Cancer

Joachim von Pawel, Robert M. Jotte, David R. Spigel et al. · 2014 · Journal of Clinical Oncology

PURPOSE: Amrubicin, a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials. This phase III trial compared the safety and efficacy of amrubicin…

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Negative / Null Result ReportOpen accessMedicine

Non-superiority of lumen-apposing metal stents over plastic stents for drainage of walled-off necrosis in a randomised trial

Ji Young Bang, Udayakumar Navaneethan, Muhammad K. Hasan et al. · 2018 · Gut

OBJECTIVE: Although lumen-apposing metal stents (LAMS) are increasingly used for drainage of walled-off necrosis (WON), their advantage over plastic stents is unclear. We compared efficacy of LAMS and plastic stents for WON drainage.…

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Negative / Null Result ReportOpen accessMedicine

Early Results of the Swiss Multicentre Bypass or Sleeve Study (SM-BOSS)

Ralph Peterli, Yves Borbély, Béatrice Kern et al. · 2013 · Annals of Surgery

In Brief Objective: Laparoscopic sleeve gastrectomy (LSG) has been proposed as an effective alternative to the current standard procedure, laparoscopic Roux-en-Y gastric bypass (LRYGB). Prospective data comparing both procedures are rare.…

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Negative / Null Result ReportOpen accessMedicine

HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research

Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein et al. · 2021 · Circulation

Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular risk. Low HDL-C is also associated with increased risk of…

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Negative / Null Result ReportOpen accessMedicine

Colorectal and Other Cancer Risks for Carriers and Noncarriers From Families With a DNA Mismatch Repair Gene Mutation: A Prospective Cohort Study

Aung Ko Win, Joanne Young, Noralane M. Lindor et al. · 2012 · Journal of Clinical Oncology

PURPOSE: To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the general population. PATIENTS AND METHODS: We prospectively followed a…

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Negative / Null Result ReportMedicine

Formula choice: Hoffer Q, Holladay 1, or SRK/T and refractive outcomes in 8108 eyes after cataract surgery with biometry by partial coherence interferometry

Petros Aristodemou, Nathaniel E. Knox Cartwright, J M Sparrow et al. · 2010 · Journal of Cataract & Refractive Surgery

PURPOSE: To assess how intraocular lens (IOL) formula choice affects refractive outcomes after cataract surgery using IOLMaster biometry. SETTING: Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham,…

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Negative / Null Result ReportOpen accessMedicine

No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over

Jane Warwick, Emanuela Falaschetti, Kenneth Rockwood et al. · 2015 · BMC Medicine

BACKGROUND: Treatment for hypertension with antihypertensive medication has been shown to reduce stroke, cardiovascular events, and mortality in older adults, but there is concern that such treatment may not be appropriate in frailer older adults. To investigate whether there is an interaction between effect of treatment for hypertension and frailty in older adults, we calculated the frailty index (FI) for all available participants from the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 an

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