Negative / Null Result ReportMedicine
Brian K. Yorkgitis, Danielle Tatum, Sharven Taghavi et al. · 2021 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND Trauma teams are often faced with patients on antithrombotic (AT) drugs, which is challenging when bleeding occurs. We sought to compare the effects of different AT medications on head injury severity and hypothesized that AT…
View details →Negative / Null Result ReportOpen accessMedicine
Lei Sun, Sergey Yagoda, Baiyun Yao et al. · 2019 · Clinical Drug Investigation
BACKGROUND AND OBJECTIVE: Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine…
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Kirsi‐Maija Kaukonen, Suvi T. Vaara, Ville Pettilä et al. · 2013 · Critical Care
INTRODUCTION: Transfusion of red blood cells (RBCs) and, in particular, older RBCs has been associated with increased short-term mortality in critically ill patients. We evaluated the association between age of transfused RBCs and acute kidney injury (AKI), hospital, and 90-day mortality in critically ill patients. METHODS: We conducted a prospective, observational, predefined sub-study within the FINNish Acute Kidney Injury (FINNAKI) study. This study included all elective ICU admissions with expected ICU stay of more than 24 hours and all emergency admissions from September to November 2011.
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Thi Yen Loan Le, Hilda A. Pickett, Andrian Yang et al. · 2019 · Scientific Reports
We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and adventitial cell fraction. Here we further characterise PDGFRα/CD90-expressing cardiac MSCs (PDGFRα + cMSCs) and use human telomerase reverse transcriptase (hTERT) over-expression to increase cMSCs ability to repair the heart after induced myocardial infarction. hTERT over-expression in PDGFRα + cardiac MSCs (hTERT + PDGFRα + cMSCs) modulates cell differentiation, proliferation, survival and angiogenesis re
View details →Failed Experiment ReportOpen accessMedicine
Penelope‐Georgia Papayanni, D. Chasiotis, Kiriakos Koukoulias et al. · 2021 · Clinical Infectious Diseases
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an urgent need for the development of effective therapies for coronavirus disease 2019 (COVID-19). METHODS: We first tested SARS-CoV-2-specific…
View details →Negative / Null Result ReportOpen accessMedicine
Santiago Moreno, Bernardino Alcázar-Navarrete, Carlos Dueñas et al. · 2022 · Drug Design Development and Therapy
The aim of this report is to review the literature and shed light on the uncertainties surrounding the use of antiviral agents in general and remdesivir in COVID-19 patients. This review evaluated a battery of antiviral compounds and their…
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Ana C. Ruiz Pardo, John Paul Minda · 2022 · Acta Psychologica
The present study was a pre-registered direct replication of Ward et al.'s (2017) second experiment (OSF pre-registration found at: https://osf.io/5fq4r). This replication assigned both smartphone location (on desk, in pocket/bag, or outside of the testing room) and smartphone power (on, or off) for a total of six conditions. Participants completed an automated operation span (OSpan) task, a Cue-Dependent Go/No-Go task, and the smartphone attachment and dependency inventory. It was hypothesized that performance on an attention-demanding task (i.e., the OSpan task) would be worse for those in c
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Jong Hoon Hyun, Moo Hyun Kim, Yujin Sohn et al. · 2021 · BMC Infectious Diseases
Abstract Background Coronavirus disease 2019 (COVID-19) is associated with acute respiratory distress syndrome, and corticosteroids have been considered as possible therapeutic agents for this disease. However, there is limited literature on the appropriate timing of corticosteroid administration to obtain the best possible patient outcomes. Methods This was a retrospective cohort study including patients with severe COVID-19 who received corticosteroid treatment from March 2 to June 30, 2020 in seven tertiary hospitals in South Korea. We analyzed the patient demographics, characteristics, and
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Hwa Young Ahn, Hye Sook Min, Yohwan Yeo et al. · 2015 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Previous studies on the extent to which radioactive iodine (RAI) therapy for thyroid cancer increases the risk of subsequently developing breast cancer have given conflicting results. OBJECTIVE: This study aimed to evaluate the…
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Tanguy Y. Seiwert, Sara Kochanny, Kevin Wood et al. · 2020 · Cancer
BACKGROUND: Patients with cetuximab-resistant, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) have poor outcomes. This study hypothesized that dual blockade of mammalian target of rapamycin and epidermal growth factor…
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Laurent Chiche · 2012 · Therapeutics and Clinical Risk Management
Belimumab is the first biologic approved for patients with systemic lupus erythematosus (SLE). Belimumab is the first of a new class of drug targeting B cell-stimulating factors or their receptors to reach the market. Its target, BLyS,…
View details →Negative / Null Result ReportOpen accessMedicine
Kogieleum Naidoo, Santhanalakshmi Gengiah, Nonhlanhla Yende‐Zuma et al. · 2022 · EClinicalMedicine
Background HIV-TB treatment integration reduces mortality. Operational implementation of integrated services is challenging. This study assessed the impact of quality improvement (QI) for HIV-TB integration on mortality within primary…
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Yan Tong, Peter Jezzard, Thomas W. Okell et al. · 2020 · Magnetic Resonance in Medicine
PURPOSE: To improve the labeling efficiency of pseudo-continuous arterial spin labeling (PCASL) at 7T using parallel transmission (pTx). METHODS: maps were acquired in the labeling plane for tagging pulse design. Complex weights of the labeling pulses for each of the 8 transmit channels were calculated to produce a homogenous radiofrequency (RF) -shimmed labeling across the ROIs. Variable-Rate Selective Excitation (VERSE) pulses were also implemented as a part of the labeling pulse train. Whole-brain perfusion-weighted images were acquired under conditions of RF shimming, VERSE with RF shimmin
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Sergio Luis‐Lima, Tomás H. Higuera Linares, Laura Henríquez-Gómez et al. · 2019 · Journal of Clinical Medicine
Type 2 diabetes mellitus represents 30-50% of the cases of end stage renal disease worldwide. Thus, a correct evaluation of renal function in patients with diabetes is crucial to prevent or ameliorate diabetes-associated kidney disease. The reliability of formulas to estimate renal function is still unclear, in particular, those new equations based on cystatin-C or the combination of creatinine and cystatin-C. We aimed to assess the error of the available formulas to estimate glomerular filtration rate in diabetic patients. We evaluated the error of creatinine and/or cystatin-C based formulas
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Lara J. Mentink, Joao Guimaraes, Myrthe Faber et al. · 2021 · NeuroImage
Structural and functional alterations of the brain in persons genetically at-risk for Alzheimer's disease (AD) are crucial in unravelling AD development. Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation. We aimed to replicate the early findings of Filippini et al, using the APOE gene, still the principal AD risk gene, and extended this with a polygenic risk score (PRS) analysis for AD, using the Human Connectome Project dataset (HCP). We include
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Pierina Navarria, Federico Pessina, Stefano Tomatis et al. · 2017 · Oncotarget
// Pierina Navarria 1, * , Federico Pessina 2, * , Stefano Tomatis 1 , Riccardo Soffietti 3 , Marco Grimaldi 4 , Egesta Lopci 5 , Arturo Chiti 5, 7 , Antonella Leonetti 9 , Alessandra Casarotti 2 , Marco Rossi 2 , Luca Cozzi 1 , Anna Maria Ascolese 1 , Matteo Simonelli 6, 7 , Simona Marcheselli 8 , Armando Santoro 6, 7 , Elena Clerici 1 , Lorenzo Bello 2 and Marta Scorsetti 1, 7 1 Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Rozzano, Italy 2 Neurosurgical Oncology Department, Humanitas Cancer Center and Research Hospital, Rozzano, Italy 3 Consultant
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Mohan Li, Yuelun Zhang, Lijian Pei et al. · 2022 · Frontiers in Oncology
Background Effects of anesthetic interventions on cancer prognosis remain controversial. There is evidence that estrogen receptor (ER)-negative breast cancer patients have an early recurrence peak. We aimed to assess the potential benefit of regional anesthesia-analgesia versus general anesthesia regarding early recurrence in breast cancer according to ER expression. Methods Based on a multicenter randomized controlled trial (clinicaltrials.gov, NCT00418457), we included all the patients from Peking Union Medical College Hospital research center in this study. The primary outcome was breast ca
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Lekshmi Santhosh, Snigdha Jain, Anna K. Brady et al. · 2017 · Annals of the American Thoracic Society
RATIONALE: It is important for attending physicians to know which behaviors influence learner perceptions. To date, two studies focusing on general medicine attending physicians have been published addressing internal medicine residents'…
View details →Negative / Null Result ReportMedicine
Amy K. Sheaffer, Min S. Lee, Dennis Hernandez et al. · 2011 · Antiviral Therapy
BACKGROUND: To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically…
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Malin Assarsson, Jan Söderman, Olaf Dienus et al. · 2020 · Acta Dermato Venereologica
Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial…
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Oluwamayokun Oshinowo, Renee Copeland, Yumiko Sakurai et al. · 2021 · Blood Advances
Key Points Human, canine, ovine, and porcine platelets exhibit disparate biophysical signatures, whereas human and murine platelets are similar. Multiple biophysical parameters integrate during clot formation, measured by bulk clot…
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Lily R. Aleksandrova, Yu Tian Wang, Anthony G. Phillips · 2017 · Chronic Stress
The prevailing hypothesis of ketamine's unique antidepressant effects implicates N-methyl-d-aspartate receptor (NMDAR) inhibition-dependent enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated transmission,…
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Catherine Gutierrez, Anthony S. Stein, Amir T. Fathi et al. · 2025 · American Journal of Hematology
Acute myeloid leukemia is a molecularly heterogenous disease caused by the rapid expansion and impaired differentiation of malignant myeloid progenitors. Overall, outcomes remain poor, and more than half of patients develop relapsed or…
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Harriet Lampe, Laura Tam, Aaron R. Hansen · 2024 · Frontiers in Pharmacology
Metastatic castrate resistant prostate cancer (mCRPC) continues to have poor survival rates due to limited treatment options. Bi-specific T cell engagers (BiTEs) are a promising class of novel immunotherapies with demonstrated success in haematological malignancies and melanoma. BiTEs developed for tumour associated antigens in prostate cancer have entered clinical testing. These trials have been hampered by high rates of treatment related adverse events, minimal or transient anti-tumour efficacy and generation of high titres of anti-drug antibodies. This paper aims to analyse the challenges f
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Alejandro Borrego-Ruiz, Juan J. Borrego · 2024 · Nutrients
BACKGROUND/OBJECTIVES: Diet is one of the major determinants of the composition and function of the gut microbiome, and diverse studies have established directional connections between gut microbiome dysbiosis and skin dyshomeostasis. Furthermore, a significant link between the gut and certain skin-related disorders has been reported. This work reviews the mechanisms underlying the relationship between nutritional factors, gut microbiome, and certain skin diseases such as acne vulgaris, alopecia, and atopic dermatitis. In addition, it explores how the modulation of the gut microbiome and human
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Simon Bowman, Raphaèle Séror, Raphaël Porcher et al. · 2025 · Annals of the Rheumatic Diseases
Primary Sjögren's disease (pSjD) is an autoimmune rheumatic disease involving exocrine glands and associated with high symptom burden (dryness, fatigue, pain), systemic features and salivary gland dysfunction. B-cell hyperactivity is common, with an increased risk of mucosa-associated lymphoid tissue lymphoma. This review describes the unmet need, scientific validity of outcome measures, optimisation of clinical trial design, therapeutic advances and how clinical improvement relates to health-related quality of life, additional quality-adjusted life years and economic benefit in pSjD. It deriv
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Stefano Fiorucci, Ginevra Urbani, Eleonora Distrutti et al. · 2025 · Pharmaceuticals
The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR ligands that have been approved for clinical use for the treatment of patients with primary biliary cholangitis (PBC) who are unresponsive or intolerant to ursodeoxycholic acid. In this narrative review, we will examine the current status and future perspective of clinical use of OCA. Based on results
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Caterina Peraldo‐Neia, Giuliana Cavalloni, Elisabetta Fenocchio et al. · 2018 · PLoS ONE
The association of anti-EGFR to gemcitabine and oxaliplatin (GEMOX) chemotherapy did not improve survival in biliary tract carcinoma (BTC) patients. Multiple mechanisms might be involved in the resistance to anti-EGFR. Here, we explored the mutation profile of EGFR extracellular domain (ECD), of tyrosine kinase domain (TKD), and its amplification status. EGFR mutational status of exons 12, 18-21 was analyzed in 57 tumors by Sanger sequencing. EGFR amplification was evaluated in 37 tumors by Fluorescent In Situ Hybridization (FISH). Kaplan-Meier curves were calculated using the log-rank test. S
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Ömer Aydın, Enis Karaarslan, Fatih Safa Erenay et al. · 2026 · Turkish Journal of Engineering
DeepSeek v3, developed in China, was released in December 2024, followed by Alibaba’s Qwen 2.5 Max in January 2025 and Qwen3 235B in April 2025. These free and open-source models offer significant potential for academic writing and content…
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Harm A.W.M. Tiddens, Eleni‐Rosalina Andrinopoulou, Joe McIntosh et al. · 2020 · PLoS ONE
A phase 3 randomized double blind controlled, trial in 238 people with cystic fibrosis (CF) and at least one nonsense mutation (nmCF) investigated the effect of ataluren on FEV1. The study was of 48 weeks duration and failed to meet its primary endpoint. Unexpectedly, while FEV1 declined, chest computed tomography (CT) scores using the Brody-II score as secondary outcome measures did not show progression in the placebo group. Based on this observation it was concluded that the role of CT scans in CF randomized clinical trials was limited. However, more sensitive scoring systems were developed
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