Negative / Null Result ReportOpen accessMedicine
Zhiyong Liu, Weitao Yao, Yao Zhao et al. · 2021 · Cancer Management and Research
PURPOSE: Anlotinib is a novel tyrosine kinase inhibitor with promising anti-tumor activity in patients with advanced soft tissue sarcomas (STS) in China. Liposomal doxorubicin monotherapy showed an encouraging effect on this disease. The…
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Ruby Yu, Grace Leung, Jean Woo · 2021 · International Journal of Environmental Research and Public Health
(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video
View details →Negative / Null Result ReportOpen accessMedicine
Wilhelmina G. Melsen, Anne Marie G. A. de Smet, Jan Kluytmans et al. · 2011 · British journal of surgery
BACKGROUND: Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) are effective in improving survival in patients under intensive care. In this study possible differential effects in surgical and…
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Gonzague Jourdain, Sophie Le Cœur, Nicole Ngo‐Giang‐Huong et al. · 2013 · PLoS Medicine
BACKGROUND: Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was to determine whether a CD4-based monitoring and switching strategy would provide a similar clinical outcome compared to the standard VL-based strategy in Thailand. METHODS AND FINDINGS: The Programs for HIV Prevention and Treatment (PHPT-3) non-inferiority randomized clinical trial compared a treatment switching strategy based on CD4-only (CD4) monitoring versus viral-load (VL
View details →Negative / Null Result ReportMedicine
Emilie Sundqvist, Peter Sundström, Magdalena Lindén et al. · 2012 · Neurology
BACKGROUND: Epstein-Barr virus infection, smoking, HLA-A*02, and DRB1*15 have all been proposed as risk factors for multiple sclerosis (MS). In 2010, Simon et al. described an interaction on the multiplicative scale between EBNA1…
View details →Negative / Null Result ReportOpen accessMedicine
Tory A. Eisenlohr‐Moul, Susan S. Girdler, Jacqueline L. Johnson et al. · 2017 · Depression and Anxiety
BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some…
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Yuri Chaves Martins, Graziela Maria Zaniní, John A. Frangos et al. · 2012 · PLoS ONE
BACKGROUND: Low nitric oxide (NO) bioavailability plays a role in the pathogenesis of human as well as of experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA (PbA). ECM is partially prevented by administration of the NO-donor dipropylenetriamine NONOate (DPTA-NO) at high concentration (1 mg/mouse), which also induces major side effects such as a sharp drop in blood pressure. We asked whether alternative strategies to improve NO bioavailability with minor side effects would also be effective in preventing ECM. METHODOLOGY/PRINCIPAL FINDINGS: Mice were infected with PbA and pro
View details →Negative / Null Result ReportOpen accessMedicine
Michael Huang, Kenneth G. Lucas · 2010 · Sarcoma
Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches available, including the different upfront and salvage chemotherapy regimens, the role for stem cell transplantation, and potential use of immunotherapy.
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João Pedro Ferreira, Francisco Vasques‐Nóvoa, Diana Ferrão et al. · 2022 · Diabetes Care
OBJECTIVE: Patients with type 2 diabetes (T2D) have a high risk for developing heart failure (HF), which is associated with poor prognosis. Fenofibrate may reduce HF events through multiple mechanisms. We sought to study the effect of…
View details →Replication FailureOpen accessMedicine
Lena Hafrén, Elísabet Einarsdóttir, Erna Kentala et al. · 2015 · PLoS ONE
BACKGROUND: Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts. METHODS: We investigated 53 gene polymorphisms in a Finnish cohort of 624 cases and 778 controls. A positive association signal was followed up in a tagging approach and tested in an independent Finnish cohort of 205 cases, in a British cohort of 1269 trios, as well as in two cohorts from the United States (US); on
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Junjie Ding, Nguyễn Thụy Thương Thương, Toi Van Pham et al. · 2020 · Clinical Pharmacology & Therapeutics
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e
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Virve I. Enne, Susan Stirling, Julie Barber et al. · 2025 · Intensive Care Medicine
PURPOSE: INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia (HAP and VAP). METHODS: This pragmatic multicentre, open-label RCT…
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Ali Azarbarzin, Daniel Vena, Neda Esmaeili et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and…
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Ruben A. Mesa, Jean‐Jacques Kiladjian, Srđan Verstovšek et al. · 2013 · Haematologica
Prior to Janus kinase inhibitors, available therapies for myelofibrosis were generally supportive and did not improve survival. This analysis compares efficacy outcomes of patients with myelofibrosis in the control arms (placebo [n=154]…
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Christopher J. Hoffmann, Katherine Fielding, Salome Charalambous et al. · 2010 · AIDS
OBJECTIVE: To assess the effectiveness of cotrimoxazole preventive therapy (CPT) among individuals with CD4 cell count above 200 cells/microl and varying WHO clinical stages in reducing mortality during combination antiretroviral therapy…
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Ellen W. Demerath, Nikki Lynn Rogers, Derek Reed et al. · 2010 · Annals of Human Biology
BACKGROUND: Elevated visceral adiposity is strongly predictive of cardiometabolic disease, but, due to the high cost of biomedical imaging, assessment of factors contributing to normal variation in visceral (VAT) and subcutaneous (SAT)…
View details →Replication FailureMedicine
Joyce O’Shaughnessy, D Paul, Christopher Stokoe et al. · 2010 · Cancer Research
Abstract Background: Combination regimens incorporating anthracyclines and taxanes are among the most effective for EBC and are particularly suitable for pts with high-risk disease. Significant efficacy benefit has been shown in phase III…
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Cissy Kityo, Alexander J. Szubert, Abraham Siika et al. · 2018 · PLoS Medicine
BACKGROUND: In sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality associated with immune reconstitution inflammatory syndrome (IRIS), a paradoxical response to successful ART. Integrase inhibitors lead to significantly more rapid declines in HIV viral load (VL) than all other ART classes. We hypothesised that intensifying standard triple-drug ART with the integrase inhibitor, raltegravir, would reduce HIV VL fast
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Hongbo Zhou, Jiping Zhu, Jiagang Tu et al. · 2010 · The Journal of Infectious Diseases
To study the effect of NS1 eIF4GI binding domain on virulence and pathogenicity of H5N1 influenza A virus, 5 recombinant H5N1 viruses encoding eIF4GI binding domain-truncated NS1 proteins and parental NS1 (NS1‐wt) were generated by an…
View details →Negative / Null Result ReportMedicine
Hye-Ryoung Kim, Choi-Ku Park, Jae‐Ku Oem et al. · 2010 · Journal of General Virology
We characterized low pathogenic avian influenza (LPAI) H5N2 and H9N2 viruses isolated in South Korea from 2008 to 2009. Genetic analysis of the H5N2 viruses isolated from wild birds and domestic ducks demonstrated that they were related to…
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Mads Lawaetz, Fatima Birch‐Johansen, Søren Friis et al. · 2016 · Acta Oncologica
Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national…
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Feiyu Niu, Yi‐Long Wu · 2014 · Experimental Hematology and Oncology
Since the recognition of epidermal growth factor receptor (EGFR) as a therapeutic target, EGFR tyrosine kinase inhibitors (TKIs) have been used in lung cancer patients with EGFR mutations, which has been a major breakthrough for lung cancer treatment.. The progression-free survival (PFS) of patients with EGFR mutations treated with EGFR TKIs is significantly prolonged compared with that of patients who underwent standard chemotherapy. However, all patients who initially respond to EGFR TKIs eventually develop acquired resistance (AR). Many small molecule agents and monoclonal antibodies (McAb)
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Valery Matthys, Elena E. Gorbunova, Irina N. Gavrilovskaya et al. · 2011 · Journal of Virology
Hantaviruses primarily infect the endothelial cell lining of capillaries and cause two vascular permeability-based diseases. The ability of pathogenic hantaviruses to regulate the early induction of interferon determines whether…
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James West, Bryan Voss, Leo Pavliv et al. · 2016 · Pulmonary Circulation
Right ventricular (RV) failure is the primary cause of death in pulmonary arterial hypertension (PAH) and is a significant cause of morbidity and mortality in other forms of pulmonary hypertension. There are no approved therapies directed…
View details →Negative / Null Result ReportOpen accessMedicine
Dafna Ben Yaakov, Yana Shadkchan, Nathaniel D. Albert et al. · 2017 · Journal of Antimicrobial Chemotherapy
Objectives: Over the last 30 years, the number of invasive fungal infections among immunosuppressed patients has increased significantly, while the number of effective systemic antifungal drugs remains low. The aim of this study was to…
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Wouter Claeys, Lien Van Hoecke, Anja Geerts et al. · 2022 · Scientific Reports
Hepatic encephalopathy (HE) is a common complication of chronic liver disease, characterized by an altered mental state and hyperammonemia. Insight into the brain pathophysiology of HE is limited due to a paucity of well-characterized HE models beyond the rat bile duct ligation (BDL) model. Here, we assess the presence of HE characteristics in the mouse BDL model. We show that BDL in C57Bl/6j mice induces motor dysfunction, progressive liver fibrosis, liver function failure and hyperammonemia, all hallmarks of HE. Swiss mice however fail to replicate the same phenotype, underscoring the import
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Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto et al. · 2019 · Arthritis Research & Therapy
Abstract Background Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used to diagnose and monitor diseases; however, accurate assessment of vascular disease activity status can be difficult. In this study, we investigated comprehensive immuno-phenotyping to explore useful biomarkers associated with clinical characteristics. Methods Consecutive patients with newly diagnosed LVV who visited our institution between May 2016 and May 2019 were en
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Woo‐Ri Shin, Hyun Tae Lee, Heejin Lim et al. · 2018 · Nature Communications
BAFF, a member of the TNF superfamily, has been recognized as a good target for autoimmune diseases. Belimumab, an anti-BAFF monoclonal antibody, was approved by the FDA for use in treating systemic lupus erythematosus. However, the molecular basis of BAFF neutralization by belimumab remains unclear. Here our crystal structure of the BAFF-belimumab Fab complex shows the precise epitope and the BAFF-neutralizing mechanism of belimumab, and demonstrates that the therapeutic activity of belimumab involves not only antagonizing the BAFF-receptor interaction, but also disrupting the formation of th
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Kenji Fujiwara, May Tun Saung, Hao Jing et al. · 2020 · Journal for ImmunoTherapy of Cancer
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal…
View details →Replication FailureOpen accessMedicine
Jing You, Shuchai Zhu, Jiancheng Li et al. · 2022 · International Journal of Radiation Oncology*Biology*Physics
PurposeThe standard dose (SD) of definitive concurrent chemoradiotherapy (dCRT) remains 50.4 Gy in patients with esophageal cancer; a higher dose, when applied with conventional radiation therapy techniques, increases toxicities without…
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