12,262 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Connacher, Hu, Roden et al. · 2026 · RNA biology
Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo…
View details →Taylor, Roberts, Rayner · 2026 · Viruses
Chikungunya virus (CHIKV) is an alphavirus that infects dermal fibroblasts as a primary target cell during natural mosquito-borne transmission. While primary human dermal fibroblasts (hDFs) have been implicated as a key source of type I…
View details →Canton, Ceballos, Canton et al. · 2026 · Pharmaceutics
Background/Objectives: Combination of antiparasitic drugs with different mechanisms of action has been suggested as an effective strategy to delay the development of parasite resistance. Considering the need to understand the…
View details →Perez Arteaga, Yeh · 2026 · Nutrients
Surgical trauma triggers a complex metabolic and inflammatory response that can profoundly affect patient recovery and clinical outcomes. The magnitude of this stress response correlates with surgical complexity, patient comorbidities, and…
View details →Tan, Lye, Patel et al. · 2026 · International journal of molecular sciences
Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this…
View details →Ullah, Li, Aljasir et al. · 2026 · Life (Basel, Switzerland)
Background : Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with limited treatment options. Tumors harboring the BRAF V600E mutation exhibit aggressive behavior and present therapeutic challenges. Although…
View details →Kuchana, Repalle, Alahari et al. · 2026 · Cancers
Artificial intelligence (AI) is reshaping oncology at every stage of the cancer care pathway, from population-level screening through molecular diagnosis, treatment planning, and post-treatment surveillance. Despite an exponential growth…
View details →Jiang, Qi, Ma et al. · 2026 · Veterinary research
Feline calicivirus (FCV) evolves rapidly under immune pressure, yet the genetic basis of antigenic escape remains poorly understood, particularly when sequence divergence is limited. We isolated 13 FCV strains from cats in Jilin Province,…
View details →Liu, Su, Gong et al. · 2026 · BMC infectious diseases
Chlamydia abortus primarily causes abortion and stillbirth in animals and is associated with pregnancy-related complications in humans. However, it is an extremely rare cause of pneumonia in humans. While Chlamydia psittaci is a…
View details →Faurholt-Jepsen, Hammershøi, Bruun et al. · 2026 · Journal of affective disorders
Distinguishing between bipolar disorder type I and II constitutes a significant clinical challenge that relies on retrospective patient recall. Misclassification carries risks of inappropriate pharmacological management. Digital…
View details →He, Lin, Zhang et al. · 2026 · Diabetes research and clinical practice
Cardiovascular-kidney-metabolic (CKM) syndrome defines a pathophysiological continuum linking obesity, metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Stages 0-3 represent a critical subclinical window for…
View details →Romero-Alfano, Prats, Raldúa et al. · 2026 · The Science of the total environment
Mixture toxicity studies on neuroactive chemicals remain scarce and often rely on simplified combinations of compounds with known modes of action (MoA), despite the frequent non-monotonicity of neuroactive responses. Furthermore, real…
View details →Lin, Li, Cheng et al. · 2026 · Briefings in bioinformatics
Current metabolomics approaches predominantly rely on group-level differential abundance screening. While effective for identifying biomarkers, this paradigm often overlooks upstream regulatory hubs and fails to resolve the…
View details →Oduncu, Zor, Çimen et al. · 2026 · Forensic science, medicine, and pathology
Gunshot wounds (GSW) pose serious risks to both mother and fetus. Determining the trajectory and cause of death in the fetus in GSW is of forensic importance. This study aims to contribute to the literature with two rare GSW cases leading…
View details →Lu, Wang, Chen et al. · 2026 · Cell death discovery
Proper oocyte maturation is critical for female fertility, yet whether cuproptosis, a recently identified copper-dependent cell death pathway, affects meiotic maturation remains unknown. Here, we show that Cu(II)-elesclomol (ELC-Cu(II))…
View details →Walther, Hänel, Krohn et al. · 2026 · International journal of sports physiology and performance
To compare effects of block periodization against evenly distributed low-intensity training on endurance performance in well-trained junior cross-country (XC) skiers. Twenty junior cross-country skiers participated in a crossover design…
View details →LaRue-Nolan, Flores, Vera et al. · 2026 · Molecular and cellular biology
Nuclear envelope (NE) proteins are essential for maintaining nuclear morphology, a central process controlling cellular phenotypes. While these proteins and structures are largely characterized in developmental biology, their function and…
View details →Gu, Wen, Liu et al. · 2026 · Circulation
Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion (ie, Na + /H + and Ca 2 + ) cycling underlies reduced cardiac contractility. The…
View details →Srimanan, Sawangsribanterng, Poolsawat et al. · 2026 · Cureus
Internuclear ophthalmoplegia (INO) is a classic neuro-ophthalmologic syndrome caused by disruption of the medial longitudinal fasciculus (MLF), resulting in impaired adduction of the affected eye and abducting nystagmus of the…
View details →Patel, Patel · 2026 · Cureus
Chronic pain is a complex phenomenon whose assessment involves not only physiological but also psychological and social components. Due to its subjective and variable nature, accurately measuring chronic pain remains challenging in both…
View details →Songthap, Wanaratwichit, Mekrungrongwong · 2026 · BMC public health
Despite existing efforts, premarital sex among Thai adolescents remains a critical public health concern, exacerbated by nearly universal smartphone access and prolonged daily digital exposure. Traditional surveillance often fails to…
View details →Krida, Tang, Mangalath et al. · 2026 · Nature communications
Thin-shell structures, found in biological systems such as beetle carapaces and widely used in aerospace and civil engineering, achieve remarkable strength-to-mass ratios given their slenderness and curved geometries. However, their…
View details →Versyck, Tollenaere, Schelfaut et al. · 2026 · Journal of spine surgery (Hong Kong)
Cervical kyphotic deformity is a recognized complication following posterior cervical spine surgery, particularly after laminectomy. However, post-laminoplasty kyphosis remains an underreported entity. We present a case of progressive…
View details →Cruciani, Cafaro, Perricone et al. · 2026 · Clinical and experimental rheumatology
This study aimed to compare different treatment strategies for rheumatoid arthritis (RA) patients following inadequate response to initial methotrexate (MTX) therapy, evaluating clinical outcomes, tolerability profiles, and factors…
View details →Zhang, Wei, Wu et al. · 2026 · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Alcohol-associated liver disease (ALD) progresses from steatosis to steatohepatitis, but the underlying mechanisms remain unclear. Here, we investigated SETDB1's role in ALD progression involving LC3B-mediated LC3-associated phagocytosis…
View details →Bonglack, Carrel-Lammert, Hoehn et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Acute urinary tract infections (UTIs) are common after prolapse and anti-incontinence surgery, with incidence rates varying from 14% to 64%. The objective was to decrease rates of symptomatic urinary tract infections in patients undergoing…
View details →Mizuno, Chretien, Nishida et al. · 2026 · Journal of gastroenterology
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), including cholangitis, a rare but clinically severe hepatobiliary phenotype. Whether potassium-competitive acid blockers (PCABs) such as vonoprazan are…
View details →Wu, Liu, Wang et al. · 2026 · Scientific reports
Prolonged preoperative fasting is common in pediatric anesthesia, yet its effect on gastric residual volume (GRV) remains inadequately explored. We conducted a prospective cross-sectional study to examine the association between prolonged…
View details →Costa de Oliveira, Caminha Souza, Cândido Alves et al. · 2026 · Clinical nutrition ESPEN
Breast cancer remains a critical global public health concern, with diet representing one of the primary modifiable lifestyle factors influencing both disease prevention and the risk of recurrence. This study aimed to evaluate the…
View details →Pham, Vu, Le et al. · 2026 · PloS one
C5a and its receptor, C5aR, are involved in the degranulation of mast cells and basophils, leading to the release of proinflammatory cytokines. However, to date, their roles in the pathogenesis of chronic spontaneous urticaria (CSU) remain…
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