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Browse the failure-mode index

12,262 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Opposing Roles of Testosterone and Cortisol in Prosocial Risk-Taking.

Huang S, Zhang D, Zhuang J · 2026 · Behavioral sciences (Basel, Switzerland)

Prosocial risk-taking is defined as engagement in altruistic behaviors that may have personal costs. Emerging research indicates that testosterone-a gonadal steroid hormone-is linked to behaviors aimed at promoting one's social status. In…

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Negative / Null Result ReportOpen accessMedicine

Social identification and paranoia.

Greenburgh A, Zamperetti L, Bell V et al. · 2024 · Royal Society open science

Paranoia is associated with variation in social behaviour, such as lower inclination to trust others or to behave generously in economic game settings. Such variation may stem, in part, from a reduced tendency to socially identify with…

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Negative / Null Result ReportMedicine

Effects of an Exercise Program to Reduce Falls in Older People Living in Long-Term Care: A Randomized Controlled Trial.

Taylor LM, Parsons J, Moyes SA et al. · 2024 · Journal of the American Medical Directors Association

Objectives To investigate the effect of an exercise program on falls in intermediate and high-level long-term care (LTC) residents and to determine whether adherence, physical capacity, and cognition modified outcomes. Design Randomized…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Transcranial Near-infrared Laser Therapy on Chronic Ischemic Stroke Patients: A Randomized, Single-blind, Sham-controlled Trial.

Hassan M, Al Balah O, Hegazy A et al. · 2026 · Journal of the Saudi Heart Association

Background Transcranial photobiomodulation (TPBM) using near-infrared (NIR) light is a novel, non-invasive neuromodulation strategy with potential to enhance neurorecovery. While preclinical studies are promising, clinical evidence in…

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Negative / Null Result ReportOpen accessMedicine

Sneezing in response to naturalistic bright light exposure.

Bickerstaff L, Trinkl J, Munkwitz S et al. · 2025 · F1000Research

Background The photic sneeze reflex (PSR) is a common but underexplored phenomenon where bright light triggers sneezing, affecting ~30% of the population. This study aimed to characterise the light conditions inducing PSR. Methods One male…

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Negative / Null Result ReportOpen accessMedicine

Effect of <i>Echinacea purpurea</i> on cytokine gene expression (IL10, IL1β, TNFα, IFNγ), telomere length, lipid peroxidation, and nitric oxide in broilers reared at high altitude.

Bahadoran S, Vaeznia S, Hassanpour H · 2026 · Veterinary and animal science

This study evaluated the effects of dietary Echinacea purpurea supplementation on immune regulation, oxidative stress, and cellular aging in broiler chickens reared at high altitude (2100 m). One hundred and eight day-old male Ross 308…

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Negative / Null Result ReportOpen accessMedicine

Achievement (not effort) makes people feel entitled to rewards.

Cusimano C, Kim J, Wong J · 2025 · Proceedings of the National Academy of Sciences of the United States of America

It is common to say that people feel entitled to rewards-they think they have earned or deserve them-based on their effort and achievement. However, effort and achievement draw on different principles to justify reward. They can also…

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Failed Experiment ReportOpen accessMedicine

The Causal Effects of Inflammation and Coagulation-Related Biomarkers on Sepsis-Related Complications: A Mendelian Randomization Study.

Yao Q, Yao Y, Liao Z et al. · 2026 · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

BackgroundSepsis and its complications pose a major global health burden. Mendelian randomization (MR) provides a genetic approach to assess causality.MethodsWe conducted a two-sample Mendelian randomization (MR) study using data from…

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Failed Experiment ReportOpen accessMedicine

Nudging accurate scientific communication.

Allard A, Clavien C · 2023 · PloS one

The recent replicability crisis in social and biomedical sciences has highlighted the need for improvement in the honest transmission of scientific content. We present the results of two studies investigating whether nudges and soft social…

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Negative / Null Result ReportMedicine

Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.

Abelovska, Malinova, Sucha et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

This pilot study evaluated "Your Health Belongs to You," a six-week group intervention combining psychotherapy and exercise to improve quality of life, emotional health, and symptom management in individuals with Multiple Sclerosis (MS),…

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Negative / Null Result ReportMedicine

Effects, Acceptability, and Use of a Dynamically Tailored Mobile What Do You Drink Intervention to Reduce Excessive Drinking Among Adolescents and Young Adults in the Netherlands: Randomized Controlled Trial.

van Keulen, Voogt, Kleinjan et al. · 2026 · JMIR mHealth and uHealth

Excessive alcohol consumption among adolescents and young adults is a serious health problem. Dynamically tailored interventions could reduce their excessive drinking. We therefore developed "What Do You Drink" (WDYD), a 17-week…

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Negative / Null Result ReportMedicine

Comparison of Submental Muscle Activation and Tongue Pressure of Tongue Hold, Effortful Swallow and Mendelsohn Maneuvers in Different Gravitational Positions.

Cengiz, Y&#x131;ld&#x131;r&#x131;m, Ya&#x15f;aro&#x11f;lu et al. · 2026 · Dysphagia

This study aimed to investigate the effects of Tongue Hold Maneuver (THM), Mendelsohn Maneuver (MM), and Effortful Swallow Maneuver (ESM) performed under different gravitational positions (90&#xb0; sitting, 45&#xb0; sitting, supine, and…

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Negative / Null Result ReportMedicine

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum.

Bakhshalipoor, Bolandi, Nahidi et al. · 2026 · Scientific reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

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Negative / Null Result ReportMedicine

Cholinesterase activity determines the action potential-dependent increase in glycine receptor-mediated inhibitory synaptic transmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat.

Kawamura, Masaki, Kato · 2026 · Journal of pharmacological sciences

Acetylcholine-mediated modulation of pain-associated behaviors has been progressively well described. The mechanisms of cholinergic antinociception have been reported to involve the activation of nAChRs or mAChRs modulating GABAergic…

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