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Browse the failure-mode index

12,260 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of Inhaled Corticosteroids and Long-Acting β2-Agonists on Efferocytosis and Inflammatory Cell Survival: An In Vitro Study Relevant to COPD and Lung Cancer.

Redwan B, Biancosino C, Fischer S et al. · 2026 · International journal of molecular sciences

Efferocytosis-the tightly regulated clearance of apoptotic cells by phagocytes-maintains tissue homeostasis and is impaired in chronic obstructive pulmonary disease (COPD), where it contributes to persistent inflammation and increases the…

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Failed Experiment ReportOpen accessMedicine

Promotion of recovery from Traumatic Brain Injury (TBI) by Granulocyte Colony-Stimulating Factor (G-CSF) treatment requires cannabinoid receptor type 2 activity.

Song S, Wang B, Kong X et al. · 2025 · Journal of cannabis research

Granulocyte colony-stimulating factor (G-CSF) has the capacity to enhance brain repair following various injuries to brain. G-CSF treatment after TBI in rodents has been reported to promote brain repair, hippocampal neurogenesis, and…

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Negative / Null Result ReportMedicine

Medetomidine Administration at the Subcutaneous GV20 Acupoint Compared with the Intramuscular Route in Guinea Pigs (Cavia porcellus): Sedation Score, Onset, and Duration of Action.

Esjaita EI, Fuensalida SE, Giansanti NH et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Recent research in both humans and animals has explored alternative routes for drug administration, such as pharmacopuncture, a technique involving the subcutaneous administration of low drug doses at acupuncture points. Among these…

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Negative / Null Result ReportMedicine

The added value of artificial intelligence using Quantib Prostate for the detection of prostate cancer at multiparametric magnetic resonance imaging.

Russo T, Quarta L, Pellegrino F et al. · 2025 · La Radiologia medica

Purpose Artificial intelligence (AI) has been proposed to assist radiologists in reporting multiparametric magnetic resonance imaging (mpMRI) of the prostate. We evaluate the diagnostic performance of radiologists with different levels of…

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Negative / Null Result ReportMedicine

Rheological properties, microstructure, and encapsulation efficiency of inulin-type dietary fiber-based gelled emulsions at different concentrations

Gomes A, Costa ALR, Fasolin LH et al. · 2025 · Carbohydrate Polymers.

Gelled emulsion systems offer promising matrices for encapsulating bioactive compounds, enhancing stability, bioavailability, and controlled release. Incorporating inulin-type dietary fibers into emulsion-filled gels can innovate food…

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Negative / Null Result ReportMedicine

Caffeine's influence on vertical jump height: a real-life collegiate student-athlete approach.

Papadakis Z, Panoutsakopoulos V, Schwarz A et al. · 2025 · Journal of the International Society of Sports Nutrition

Background Caffeine's ergogenic potential in vertical jumping remains contested, particularly at dosages compliant with collegiate athletic regulations. The NCAA enforces a caffeine urinary threshold equivalent to ~5 mg/kg body mass, yet…

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Negative / Null Result ReportOpen accessMedicine

Microencapsulated Quercetin and Bifidobacterium animalis Independently Preserve Jejunal Enteric Neurons During Colorectal Carcinogenesis.

Casagrande L, Bernardo CCO, Sestak SS et al. · 2026 · Neurogastroenterology and motility

Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths, significantly disrupting enteric neurotransmission within the colon. While the effects of CRC on the enteric nervous system (ENS) of the colon are well…

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Negative / Null Result ReportOpen accessMedicine

Listen for a change? A longitudinal field experiment on listening's potential to enhance persuasion.

Santoro E, Broockman DE, Kalla JL et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America

Scholars and practitioners widely posit that listening to other people enhances efforts to persuade them. Listening may enhance persuasion by promoting cognitive processing, reducing defensiveness, and improving perceptions of the…

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Negative / Null Result ReportOpen accessMedicine

Automated AI fracture detection in initial presentation pediatric wrist X-rays: effects and benefits of adding follow-up examinations.

Scherkl M, Stranger N, Ciornei-Hoffman A et al. · 2026 · La Radiologia medica

Background Artificial Intelligence (AI) in radiology has shown promise in detecting fractures on initial X-rays. However, the role of follow-up examinations in enhancing AI performance remains unexplored. This study evaluates the impact of…

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Negative / Null Result ReportOpen accessMedicine

Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?

Toomey D, Lewis G, Tuck N et al. · 2026 · International journal of rheumatic diseases

Objective Recent evidence suggests that education on the pain-relieving effects of exercise may enhance exercise-induced hypoalgesia (EIH) in healthy individuals. However, its impact in populations with osteoarthritis (OA), where EIH…

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Negative / Null Result ReportMedicine

Belowground Interactions in a Barley Cultivar Mixture: Root Distribution and Arbuscular Mycorrhizal Contributions to Uptake of Heterogeneous Phosphorus

Siegwart L, Müller‐Stöver D, Dresbøll DB et al. · 2025 · Physiologia Plantarum.

Cultivar mixtures have the potential to mitigate abiotic stress and stabilize crop yields, but their belowground dynamics remain poorly understood. We evaluated phosphorus (P) uptake by two contrasting spring barley (Hordeum vulgare L.)…

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Negative / Null Result ReportMedicine

Data-Driven Techniques for Estimating Energy Expenditure in Wheelchair Users.

Doshmanziari R, Strand Aandahl H, Pettersen Reierstad H et al. · 2025 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Providing feedback on energy expenditure (EE) may be an important tool to support obesity prevention among manual wheelchair users (MWU). This paper presents a data-driven approach for estimating EE based on data collected from 40…

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Negative / Null Result ReportMedicine

Responses to Hypoxia and Hyperoxia in Embryonic Tiger Keelbacks (Rhabdophis tigrinus lateralis; Colubridae).

Li XM, Su S, Zhang LW et al. · 2025 · Journal of experimental zoology. Part A, Ecological and integrative physiology

Studies examining the oxygen dependency of embryonic survival, growth, and differentiation have been conducted for decades in a diverse array of animal taxa but including only one oviparous snake, the viperine water snake Natrix maura.…

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Negative / Null Result ReportMedicine

Effect of preharvest boron spraying on the firmness and microstructure of winter-harvested frozen broccoli among maturity types.

Viriyarattanasak C, Takemura Y, Hashimoto T et al. · 2025 · Journal of the science of food and agriculture

Background Softening of winter-harvested frozen broccoli is a challenge. Application of boron (B) can improve fruit texture, but its effects on processed vegetables remain unexplored. This study is the first to investigate the impact of…

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Negative / Null Result ReportMedicine

The temporal copulatory patterns of female rat sexual behavior.

Oyem JC, Heijkoop R, Snoeren EMS · 2025 · Behavioural processes

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

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Negative / Null Result ReportOpen accessMedicine

Limited Utility of the CALLY Index in Enhancing Mortality Prediction for Trauma Patients in Intensive Care Units: A Retrospective Analysis.

Kuo PJ, Huang CY, Liao KH et al. · 2026 · Risk management and healthcare policy

Background Accurate prognostication for trauma patients in intensive care units (ICUs) remains challenging. This study investigated whether incorporating the C-reactive protein-albumin-lymphocyte (CALLY) index into traditional ICU scoring…

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Negative / Null Result ReportMedicine

Increasing cervical penetrability in sheep by long-acting treatments with oxytocin (Carbetocin) and/or prostaglandin E2 (Dinoprostone).

Rodríguez-Piñón M, Casuriaga D, García-Barcelo G et al. · 2025 · Domestic animal endocrinology

The aim was to study the effect of long-acting treatments with oxytocin (Carbetocin, Cb) and/or prostaglandin E2 (Dinoprostone, Dp) on cervical penetrability and collagenolysis in synchronized ewes (12 days MAP-eCG). At 42 h post eCG, ewes…

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