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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of Three Types of Specially-Designed Myopia Control Spectacle Lenses on Astigmatism: A Two-Year Result.

Wen K, Yang B, Liu L et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose This study sought to determine whether specially-designed myopia control spectacle lenses had any effect on astigmatism in clinical practice. Methods Medical records of 74 patients (age: 6 to 12 years old) involving the use of…

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Negative / Null Result ReportMedicine

Age and sex differences in longitudinal CPAP adherence patterns.

Vodapally M, Chan-Golston AM, Sandhu J et al. · 2026 · Respiratory medicine

Study objective This study investigated long-term adherence to continuous positive airway pressure (CPAP) therapy among adult patients with obstructive sleep apnea (OSA), with a focus on identifying associations between age, sex, residual…

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Negative / Null Result ReportMedicine

Inflammation may explain part of atherosclerotic cardiovascular disease risk conferred by elevated remnant lipoproteins: a cohort and Mendelian randomization study.

Wadström BN, Wulff AB, Pedersen KM et al. · 2026 · Atherosclerosis

Background and aims Elevated remnant lipoproteins are a causal risk factor for atherosclerotic cardiovascular disease. We tested the hypothesis that low-grade inflammation can explain part of the increased risk of peripheral artery disease…

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Negative / Null Result ReportOpen accessMedicine

Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort.

Talathi R, Juhasz V, Delgado M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Data on the metabolic effects of contemporaneous gender-affirming hormone therapy (GAHT) are limited. Objective To characterize the metabolic effects of GAHT ie, estradiol with anti-androgen therapy. Design Prospective…

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Negative / Null Result ReportMedicine

Active Aging: Learning English and Developing Fine Psychomotor Abilities.

Baranowska K, Dylewski R, Fugiel J et al. · 2026 · Experimental aging research

Background Recent studies highlight that cognitive processes involved in learning share neural pathways with those controlling fine motor skills. Building on this insight, the mini-EDUball method was developed to integrate cognitive and…

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Negative / Null Result ReportMedicine

Profession-Specific Ageism Changes Following a Two-Day Long-Term Care Placement in Dental Students.

Izumi M, Mizutani S, Fujimoto A et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Background Ageism among dental students can impede equitable geriatric care. Developing educational interventions to reduce profession-specific and general ageist attitudes is an urgent priority in aging societies. Objective To determine…

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Negative / Null Result ReportMedicine

Impact of Emicizumab on Coagulation Potential in Plasma From Healthy Women and Carriers of Haemophilia A During Late Pregnancy.

Takeyama M, Kimura F, Furukawa S et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Background Intra-cranial haemorrhage (ICH) in neonates with haemophilia A (HA) remains a serious perinatal complication. Prophylactic administration of emicizumab (Emi) to pregnant HA carriers has been discussed as a potential preventive…

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Null DatasetMedicine

Integrating systemic toxicity and toxicokinetic data to inform the need for subchronic dog studies in human health safety assessments of agrochemicals.

Murphy L, Mingoia R, Bianchi E et al. · 2026 · Regulatory toxicology and pharmacology : RTP

Regulatory testing for agrochemicals has traditionally included a 90-day toxicity study in a non-rodent species, usually the dog. With growing emphasis on the 3Rs-replacement, reduction, and refinement of animal use-and increased adoption…

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Negative / Null Result ReportMedicine

A Video Analysis Study Examining Neuromuscular Training Warm-Up Practices in Youth Soccer.

Lutz D, van den Berg C, Neill MG et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

Objectives To investigate time spent completing neuromuscular training (NMT) exercises in youth soccer team warm-up across a season considering sex, level of play, session type, and coach exposure and awareness of NMT. Design…

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Negative / Null Result ReportMedicine

Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT).

Pathak BK, Maurya M, Mishra N et al. · 2026 · Clinical pediatrics

Microcytic hypochromic anemia is common in severe acute malnutrition (SAM) children, but macrocytic anemia (vitamin B12/folate deficiency) is not uncommon. Vitamin B12 deficiency leads to anemia and developmental slowing. We looked for the…

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Negative / Null Result ReportOpen accessMedicine

An Online Pilates Program for People with Hypermobility: A Pragmatic Clinical Trial Looking at Function, Interoception, Kinesiophobia, and Physical Activity Levels.

Russek LN, Di Bon J, Herbland A et al. · 2026 · Journal of multidisciplinary healthcare

Purpose This study evaluated whether an independent, online modified Pilates program alters function, interoception (internal body awareness), activity levels, and kinesiophobia (fear of movement) in people with symptomatic joint…

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Negative / Null Result ReportMedicine

Variations in outcomes following burn injury and admission to an Australian or New Zealand intensive care unit: A retrospective data linkage cohort study.

Garside T, Udy A, Reade MC et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Introduction The Burns Registry of Australia and New Zealand (BRANZ) has been used to identify significant variation in burn injury management and outcomes across Australia and New Zealand. This study aimed to assess variation in clinical…

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Negative / Null Result ReportMedicine

The Effect of a Mobile Game Developed for Children with Familial Mediterranean Fever on Disease Management and Quality of Life: A Randomized Controlled Trial.

Kaş Alay G, Mutlu B · 2026 · Games for health journal

Objective To determine the effect of training children with familial Mediterranean fever (FMF) using a mobile game (MG) or training booklet (TB) on self-efficacy, symptom management, and quality of life (HRQoL) compared with a control…

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Negative / Null Result ReportMedicine

Body temperature and time perception in morning and evening types

Erdoğan Ş, Tavat BC · 2025 · Physiology & behavior

Previous studies have suggested that time perception fluctuates throughout the day in relation to daily fluctuations of body temperature, and that there is a negative relationship between body temperature and time perception. The aim of…

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