Integrating systemic toxicity and toxicokinetic data to inform the need for subchronic dog studies in human health safety assessments of agrochemicals.
Murphy L; Mingoia R; Bianchi E; Lukacova V; Domoradzki J; Terry C; Gehen S; Brunner R · 2026 · Regulatory toxicology and pharmacology : RTP
WASTE classifies this as Null Dataset · AI classification, approximate
A negative-result dataset — reusable evidence that an expected effect wasn't there.
Abstract (excerpt)
Regulatory testing for agrochemicals has traditionally included a 90-day toxicity study in a non-rodent species, usually the dog. With growing emphasis on the 3Rs-replacement, reduction, and refinement of animal use-and increased adoption…
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Metadata source: Europe PMC · DOI 10.1016/j.yrtph.2026.106081