12,380 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Nguyen AQ, Nguyen HTN, Ho NT et al. · 2026 · Allergy and asthma proceedings
Background: Nonsteroidal anti-inflammatory drugs (NSAID) are the second most frequent cause of drug-induced hypersensitivity after β-lactam antibiotics. Diagnosing cross-intolerance reactions to NSAIDs remains challenging because…
View details →Mucci TJ, Adam JA, Hirsa AH · 2026 · Soft matter
Modeling the flow of insoluble surfactant monolayers undergoing rapid expansion and compression remains a long-standing challenge in hydrodynamics. In a recent letter, compressible flow of a DPPC monolayer in the coexisting…
View details →Feldmeier JJ, Gesell LB · 2026 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
The application of hyperbaric oxygen (HBO₂) to the treatment and prevention of late radiation injury (LRTI) is the focus for this chapter. Additional miscellaneous topics related to radiation exposure and HBO₂ will also be explored,…
View details →Valdezate S, Valiente M, Díaz-Ramón S et al. · 2026 · Frontiers in cellular and infection microbiology
Botulism is a rare but severe neurological disease caused by botulinum neurotoxins (BoNTs). Standard diagnostic methods including the mouse bioassay (SMB) and bont gene type-specific PCR, are often limited by the high genetic diversity…
View details →Kurtipek FB, Yozgat AK, Gökçek E et al. · 2026 · BMC infectious diseases
Background Febrile neutropenia (FN) is a frequent and potentially life-threatening complication in patients with hematologic malignancies. Prompt and accurate identification of bloodstream pathogens is essential to optimize antimicrobial…
View details →McCavitt DG, Culler MW, Palmer RC et al. · 2026 · The Journal of arthroplasty
Background The utility of synovial C-reactive protein (CRP) in diagnosing periprosthetic joint infection (PJI) remains controversial. This study examined the performance of synovial CRP for PJI diagnosis following total knee arthroplasty…
View details →Koh SJ, Liou WL, Gan S et al. · 2026 · Cureus
Hepatitis C virus (HCV) screening is routinely performed in patients undergoing haemodialysis (HD) to detect incident infections. Currently, patients undergoing HD are screened using enzyme immunoassays (EIA) that detect hepatitis C…
View details →Mura T, Aso M, Kawamura K et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Rapid diagnostic tests like the Xpert MRSA/SA BC assay are valuable for the early detection of Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) in positive blood cultures. However, genetic variations in target regions…
View details →Li X, Ou X, Liu X et al. · 2025 · BMC infectious diseases
BACKGROUND: In China, most health facilities for Tuberculosis(TB) prevention and treatment are not TB-designated. Underdiagnosis in non-TB-designated health facilities(NTDHFs) is a major cause of under-detection and underdiagnosis of…
View details →Guleria S, Dutta U, Mewara A et al. · 2026 · Diagnostic microbiology and infectious disease
Background Giardia duodenalis is globally distributed intestinal protozoan parasite responsible for giardiasis causing various clinical manifestations ranging from asymptomatic to chronic diarrhea and malabsorption. Accurate diagnosis is…
View details →Yang YJ, Lee MR, Chung CL et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Despite the availability of rapid tuberculosis (TB) nucleic acid amplification (NAA) testing, prevention of TB transmission within healthcare facilities remains a challenge due to ongoing difficulties in promptly isolating…
View details →Wu M, Bukowski BR, Hickman JA et al. · 2026 · The Journal of arthroplasty
Background Accurate diagnosis of periprosthetic joint infection (PJI) remains suboptimal. Of the tests used, one is the alpha defensin lateral flow assay (ADLFA). This study assessed ADLFA for the diagnosis of PJI in total hip…
View details →Ismail A, Abunasser S, Salameh IM et al. · 2026 · Microorganisms
Fourth-generation immunoassays are widely used for HIV and syphilis screening; however, false-reactive results may increase confirmatory testing and operational burden in high-throughput laboratories. This study evaluated the comparative…
View details →Kaya B, Can E, Karakurt Y et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses
Background Early-onset neonatal sepsis (EOS) remains a diagnostic challenge because clinical signs are nonspecific and blood cultures, although the diagnostic gold standard may yield false-negative results due to low blood volumes or…
View details →Wang D, Huang D, Shen H et al. · 2026 · Nature human behaviour
Human-machine partnerships are increasingly used to address grand societal challenges, yet knowledge of the comparative strengths of humans and machines to innovate is nascent. Here we compare the ability of humans (N = 9,198) and large…
View details →Hajkowicz K, Woodford J, Pillai ES et al. · 2025 · Emerging infectious diseases
Using metatranscriptomics, we identified Trubanaman virus in cerebrospinal fluid from a severely immunocompromised man who died of encephalitis in Queensland, Australia. Virus sequences were related to orthobunyaviruses previously detected…
View details →Greenfield PT, Phillips BB, Throckmorton TW et al. · 2026 · Journal of surgical orthopaedic advances
Despite studies highlighting magnetic resonance imaging (MRI)/magnetic resonance angiogram (MRA) accuracy in diagnosing shoulder pathologies, there remains a paucity of data regarding false negative results of these tests. The authors…
View details →Burleigh-Flayer H, Canatsey R, Jean PA et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were…
View details →Rosiles T, Nguyen M, Calin-Jageman RJ et al. · 2026 · eNeuro
Forming a long-term memory requires changes in neuronal transcription. What happens, though, as the memory is forgotten? And how does the transcriptional state relate to the maintenance and recall of the long-term memory? To answer these…
View details →Al Ayoubi O, Aldakak MA, Ibrahim B et al. · 2026 · Clinical case reports
Pleural tuberculosis is a common manifestation of extrapulmonary tuberculosis; however, its diagnosis remains challenging in paucibacillary disease, where clinical presentation may be atypical and microbiological tests frequently yield…
View details →Nielsen SM, Russell EM, Ellsworth RE et al. · 2025 · Journal of the National Comprehensive Cancer Network : JNCCN
Background The presence of variants of uncertain significance (VUS) should not influence clinical management; however, prior studies on breast cancer-related health care utilization in women with VUS versus negative germline genetic test…
View details →McGuier M, Bragg E, Holtzheimer P et al. · 2026 · eNeuro
There is a critical need for robust and reliable preclinical models for posttraumatic stress disorder (PTSD) to better understand pathophysiological mechanisms and support the development of novel treatments. The single prolonged stress…
View details →Salman E · 2026 · Indian journal of medical microbiology
Background The primary reason for increased lab use is inappropriate or needless test requests. Our study examined the benefits of repeated antinuclear antibody (ANA) testing and the reasons for ANA test requests in accordance with…
View details →Watanabe K, Takahashi H, Narumi R et al. · 2025 · The journal of obstetrics and gynaecology research
Non-invasive prenatal testing (NIPT) is a screening method that analyzes cell-free DNA (cfDNA) in maternal plasma to detect major aneuploidies. However, NIPT can fail to identify subtle chromosomal aberrations. We report a case in which…
View details →Hartady T, Sugandi SD, Viqih M · 2026 · Veterinary sciences
Poultry disease outbreaks are frequently multifactorial, involving complex interactions between infectious agents and environmental stressors. This report describes a case of avian influenza (AI) co-infection in a commercial broiler farm…
View details →İpek Demir K, Yılmaz D, Güvenir FA et al. · 2026 · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Background and objective Adverse drug reactions (ADRs) are a serious public health problem. This study aimed to evaluate reaction characteristics and diagnostic test results in pediatric patients in whom suspected drug allergy was…
View details →Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Cancers
Backgrounds : Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…
View details →Sridapan T, Jaturapaktrarak C, Rujirawat T et al. · 2026 · Journal of fungi (Basel, Switzerland)
Pythiosis is an emerging infectious disease caused by the oomycete Pythium insidiosum , affecting humans and animals primarily in subtropical and tropical regions. The pathogen is commonly found in swampy environments, and exposure can…
View details →Meng S, Zhao W, Zhang H et al. · 2026 · EJHaem
Objective To retrospectively analyze the early efficacy and safety of azacitidine plus lisaftoclax in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome with increased blasts (MDS-IB), providing a reliable clinical…
View details →Castle PE, Befano B, Hyer M et al. · 2026 · Journal of the National Cancer Institute
Background We demonstrated that cervical cancer risk following any screening result is lower if there is a known prior negative screening history vs an unknown screening history. We extended these findings to look at how screening performs…
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