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WASTE Journal

Browse the failure-mode index

12,250 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Preoperative Factors Associated With Postoperative Delirium in Older Patients With Cancer Undergoing Surgery: Retrospective Cohort Study.

Kumura Y, Maruta M, Yokota H et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background Post-operative delirium (POD) is a common complication in older patients with cancer undergoing surgery, leading to prolonged hospitalisation and cognitive decline. This study examined the relationship between pre-operative…

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Negative / Null Result ReportOpen accessMedicine

Barium-associated intestinal ischemia complicated with massive hepatic portal venous gas: A successful survival case report.

Xu P, Zhong S, Peng X · 2026 · The Journal of international medical research

Barium-associated intestinal ischemia is a rare but life-threatening complication following upper gastrointestinal barium contrast examinations, with an incidence of less than 0.01%. Hepatic portal venous gas is a condition secondary to…

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Negative / Null Result ReportMedicine

Diet Quality, Healthy Practices, and Psychosocial Functioning Across School Youth, Students, and Adults in Poland: A Cross-Sectional Online Survey.

Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients

Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…

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Negative / Null Result ReportMedicine

Is outcome observed in performance of clinical tests associated with patient-reported outcome measures after patellofemoral pain treatment? Secondary analysis of data from a randomized clinical trial.

Machado EM, Matthews M, Rathleff MS et al. · 2026 · Brazilian journal of physical therapy

Background Clinical functional tests for patellofemoral pain (PFP), such as step-up, step-down and squat, are commonly used in clinic practice, although the extent to which changes in these tests reflect changes in patient-reported outcome…

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Replication FailureOpen accessMedicine

Association of psychotropic medications with the use of coercive measures and recidivism during forensic psychiatric care: a Swedish nationwide register-based study.

Sitter TM, Savinen S, Andiné P et al. · 2026 · BMJ mental health

Background Patients in forensic psychiatric care (FPC) are often treated with various psychotropic medications. However, evidence regarding their effectiveness in this setting is lacking. Objective The study aimed to estimate how different…

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Negative / Null Result ReportMedicine

Long Term Growth and Rupture Risk, and Associated Factors of Splenic Artery Aneurysms in a Large Observational Cohort.

Larkio J, Söderström M, Holmström J et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective The aim of this retrospective observational study was to analyse imaging and patient related parameters of splenic artery aneurysms (SAAs) and their impact on SAA growth and rupture. Methods The term "aneurysm" was systematically…

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Replication FailureMedicine

Prognostic Markers Associated with Short-Term Mortality in Dogs Hospitalised with Acute Pancreatitis: A Retrospective Study of 192 Cases.

Juárez Sarrión C, Armas IR, Torrano Guillamón A et al. · 2026 · Animals : an open access journal from MDPI

Objectives To describe the clinical, clinicopathological and ultrasonographic characteristics of dogs with an acute pancreatitis (AP) and to identify prognostic markers associated with short-term mortality in a referral population. Methods…

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Negative / Null Result ReportMedicine

Factors Associated with Infection Control Competency Among Infection Control Nurses and Physicians in Long-Term Care Hospitals: A Cross-Sectional Study.

Choi JS, Kim KM · 2026 · Healthcare (Basel, Switzerland)

Background The number of long-term care hospitals (LTCHs) in Korea has been increasing. Because LTCHs primarily care for older adults who are vulnerable to infection, strict infection control (IC) practices are essential. This study aimed…

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Negative / Null Result ReportMedicine

Preoperative hypoalbuminemia as a prognostic factor in patients with gastric cancer undergoing radical gastrectomy: Construction of a nomogram.

Qu ZW, Zhang Y, Guo MY · 2026 · The Journal of international medical research

ObjectiveTo investigate the association of preoperative hypoalbuminemia (serum albumin <35 g/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct…

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Negative / Null Result ReportMedicine

Acetazolamide-induced metabolic acidosis in pediatric idiopathic intracranial hypertension: associations with bone mineral density, growth, and kidney function.

Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…

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Negative / Null Result ReportMedicine

Identification of Gait Patterns Associated with Paretic Propulsion and Velocity in Community-Dwelling Individuals with Stroke: A Multicenter Retrospective Study.

Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering

Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…

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Negative / Null Result ReportOpen accessMedicine

Nature Connectedness and Work Engagement in the Relationship Between Emotional Exhaustion and Life Satisfaction Among Employees.

Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education

This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…

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Negative / Null Result ReportMedicine

Aqueous PFOS exposure decouples gaseous carbon loss from mineral-associated carbon retention in controlled wetland-interface mesocosms.

Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…

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Negative / Null Result ReportMedicine

Factors associated with achieving knee flexion around one hundred and twenty five degrees and numerical rating scale around one at one year after posterior cruciate-retaining total knee arthroplasty.

Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics

Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…

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Negative / Null Result ReportMedicine

Risk factors for multidrug resistance and mortality in healthcare-associated neonatal gram-negative bloodstream infections.

Turgut H, Özdemir R, Memişoğlu F · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Purpose This study aimed to characterize pathogen distribution and antimicrobial resistance patterns of gram-negative bloodstream infections in a tertiary neonatal intensive care unit and to determine which factors were associated with…

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Negative / Null Result ReportMedicine

Risk factors and the effect of belimumab on flares during glucocorticoid tapering in systemic lupus erythematosus: A multicentre ANSWER-SLE cohort study.

Miyake H, Onishi A, Tsuji H et al. · 2026 · Modern rheumatology

To identify factors associated with flare after glucocorticoid (GC) reduction in systemic lupus erythematosus (SLE) and determine whether belimumab influences this risk. Using the ANSWER-SLE cohort, this retrospective multicentre study…

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Negative / Null Result ReportMedicine

Structural and load-dependent arterial stiffness are differentially associated with cognition or biomarkers of Alzheimer's disease and related dementias: The healthy brain study.

Deconne TM, Suerken CK, Lipford ME et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundArterial stiffness is an emerging risk factor for Alzheimer's disease (AD) and related dementias (ADRD) and is assessed by measuring pulse wave velocity (PWV). Recent mathematical modeling has allowed for the delineation of…

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Negative / Null Result ReportMedicine

Transitioning to Adult Caregiving and Grandchild Care Are Associated With Mental and Physical Health Outcomes Among Middle-Aged and Older Adults: Longitudinal Evidence From South Africa, 2015-2022.

Pengpid S, Peltzer K, Hajek A · 2026 · Australasian journal on ageing

Objectives The aim of this study was to assess the longitudinal association between transitioning to adult caregiving, grandparent childcare and mental health outcomes (depressive symptoms, life satisfaction and cognitive functioning) and…

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Negative / Null Result ReportOpen accessMedicine

Chronic kidney disease screening and associated factors among people living with HIV on anti-retroviral therapy in Dar Es Salaam, Tanzania: Hospital-based cross-sectional study.

Theophil M, Lyimo AA, Ambikile JS · 2026 · PloS one

Background Chronic Kidney Disease (CKD) is a significant global health challenge, particularly among people living with HIV (PLHIV) on antiretroviral therapy (ART). The combined effects of HIV infection, long-term ART exposure, and other…

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