Negative / Null Result ReportMedicine
Jin Kim, Se Jin Baek, Dong-Woo Kang et al. · 2017 · Diseases of the Colon & Rectum
BACKGROUND: Robotic total mesorectal excision for rectal cancer has rapidly increased and has shown short-term outcomes comparable to conventional laparoscopic total mesorectal excision. However, data for long-term oncologic outcomes are…
View details →Negative / Null Result ReportOpen accessMedicine
James Galea, Kayode Ogungbenro, Sharon Hulme et al. · 2017 · Journal of neurosurgery
OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular event with long-term morbidity and mortality. Patients who survive the initial bleeding are likely to suffer further early brain injury arising from a…
View details →Negative / Null Result ReportOpen accessMedicine
Máté Rudas, Ian Seppelt, Robert Herkes et al. · 2014 · Critical Care
INTRODUCTION: Long-term ventilated intensive care patients frequently require tracheostomy. Although overall risks are low, serious immediate and late complications still arise. Real-time ultrasound guidance has been proposed to decrease complications and improve the accuracy of the tracheal puncture. We aimed to compare the procedural safety and efficacy of real-time ultrasound guidance with the traditional landmark approach during percutaneous dilatational tracheostomy (PDT). METHODS: A total of 50 patients undergoing PDT for clinical indications were randomly assigned, after obtaining infor
View details →Negative / Null Result ReportOpen accessMedicine
Jennifer Ryan, Mark D. Peterson, Nicola Ryan et al. · 2019 · Developmental Medicine & Child Neurology
AIM: To compare mortality rates for cardiovascular disease, cancer, and respiratory disease between adults with cerebral palsy (CP) and the general population. METHOD: A cohort study was conducted using data from adults with CP in England,…
View details →Negative / Null Result ReportOpen accessMedicine
Joon‐Tae Kim, Reza Jahan, Jeffrey L. Saver et al. · 2015 · Stroke
BACKGROUND AND PURPOSE: Sparse data are available regarding the association between hyperglycemia and outcomes in acute ischemic stroke patients receiving mechanical thrombectomy (MT). We investigated whether hyperglycemia affected the…
View details →Negative / Null Result ReportMedicine
Christopher G. Salib, Nicolas Reina, Kevin I. Perry et al. · 2019 · The Bone & Joint Journal
AIMS: Concurrent hip and spine pathologies can alter the biomechanics of spinopelvic mobility in primary total hip arthroplasty (THA). This study examines how differences in pelvic orientation of patients with spine fusions can increase…
View details →Negative / Null Result ReportOpen accessMedicine
Kevin Kalinsky, Sandra Lee, Krista M. Rubin et al. · 2017 · Cancer
BACKGROUND KIT‐directed tyrosine kinase inhibitors such as imatinib have demonstrated benefits in KIT‐mutant (KIT+) mucosal, acral, vulvovaginal, and chronically sun‐damaged (CSD) melanoma. Dasatinib has superior preclinical activity in…
View details →Negative / Null Result ReportOpen accessMedicine
Hidekazu Suzuki, Juntaro Matsuzaki, Yasushi Fukushima et al. · 2014 · Neurogastroenterology & Motility
BACKGROUND: Rikkunshito, a standardized Japanese herbal medicine, is thought to accelerate gastric emptying and relieve dyspepsia, although no large-scale, randomized, placebo-controlled trials of rikkunshito have been conducted. This…
View details →Negative / Null Result ReportOpen accessMedicine
Nga M. Lau, Peter H.R. Green, Annette K. Taylor et al. · 2013 · PLoS ONE
OBJECTIVE: Gastrointestinal symptoms are a common feature in children with autism, drawing attention to a potential association with celiac disease or gluten sensitivity. However, studies to date regarding the immune response to gluten in autism and its association with celiac disease have been inconsistent. The aim of this study was to assess immune reactivity to gluten in pediatric patients diagnosed with autism according to strict criteria and to evaluate the potential link between autism and celiac disease. METHODS: Study participants included children (with or without gastrointestinal sym
View details →Negative / Null Result ReportOpen accessMedicine
Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa et al. · 2017 · BMC Cancer
BACKGROUND: Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to estimate the incidence and survival rates. Furthermore, limited information is available on the efficacy of various treatment modalities in relation to primary tumor sites. METHODS: The data for this retrospective study were drawn from the Surveillance, Epidemiology and End Resu
View details →Negative / Null Result ReportMedicine
Mary Wang · 2016 · PubMed
Anemia, defined as a hemoglobin level two standard deviations below the mean for age, is prevalent in infants and children worldwide. The evaluation of a child with anemia should begin with a thorough history and risk assessment.…
View details →Negative / Null Result ReportOpen accessMedicine
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami et al. · 2021 · Nature Communications
IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS, activation of ERK, JNK and caspase-3, impaired mitochondrial function and reduced fatty acid oxidation. Paracrine IL11 activity stimulates hepatic stellate cells and causes fibrosis. In mouse models of NASH, hepatocyte-specific deletion of Il11ra1
View details →Negative / Null Result ReportOpen accessMedicine
M. Lukasiewicz, Stéphanie Gerard, Adeline Besnard et al. · 2013 · International Journal of Methods in Psychiatric Research
The aim of this analysis was to identify Young Mania Rating Scale (YMRS) meaningful benchmarks for clinicians (severity threshold, minimal clinically significant difference [MCSD]) using the Clinical Global Impressions Bipolar (CGI-BP)…
View details →Negative / Null Result ReportOpen accessMedicine
Laura J. Wozniak, Michelle J. Hickey, Robert S. Venick et al. · 2015 · Transplantation
BACKGROUND: The role of donor-specific HLA antibodies (DSA) after pediatric liver transplantation (LTx) is not clearly established. We completed a cross-sectional study to characterize DSA in long-term survivors of pediatric LTx and assess…
View details →Negative / Null Result ReportOpen accessMedicine
Lotte A van de Stadt, Wouter H Bos, Marlies Meursinge Reynders et al. · 2010 · Arthritis Research & Therapy
INTRODUCTION: Ultrasonography (US) has better sensitivity than clinical evaluation for the detection of synovitis in early rheumatoid arthritis (RA). Patients presenting with arthralgia and a positive anti-citrullinated protein antibodies (ACPA) and/or Rheumatoid Factor (IgM-RF) status are at risk for developing RA. In the present study, US utility and predictive properties in arthralgia patients at risk for the development of arthritis were studied. METHODS: 192 arthralgia patients with ACPA and/or IgM-RF were included. Absence of clinical arthritis was confirmed by two physicians. US was per
View details →Negative / Null Result ReportMedicine
Sydney Ch’ng, Roman J. Skoracki, Jesse C. Selber et al. · 2014 · Head & Neck
BACKGROUND: Dental restoration is an integral part of head and neck cancer reconstruction. METHODS: We evaluated the success rate of osseointegrated implants in patients with head and neck cancer, comparing outcomes between implants placed…
View details →Negative / Null Result ReportMedicine
Daniel A. Shoskes, Hannah Wang, A. Scott Polackwich et al. · 2016 · The Journal of Urology
PURPOSE: Chronic prostatitis/chronic pelvic pain syndrome is a common disorder with heterogeneous etiologies and clinical features. The gut microbiome is a metabolically active ecosystem linked to systemic conditions (gut-brain axis). We…
View details →Negative / Null Result ReportOpen accessMedicine
Jennifer L. Marti, Kunal Jain, Luc G.T. Morris · 2015 · Thyroid
INTRODUCTION: The long-term sequelae of radioactive iodine (RAI) for differentiated thyroid cancer (DTC) in pediatric and young adult patients are not well-defined. Epidemiologic analyses of second primary malignancy (SPM) risk have only…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Valenzuela, Carol Brayne, Perminder S. Sachdev et al. · 2011 · American Journal of Epidemiology
An active cognitive lifestyle has been linked to dementia incidence and survival, but the separate and combined effects of its subcomponents are not clear. Data were derived from the Medical Research Council Cognitive Function and Ageing…
View details →Negative / Null Result ReportMedicine
Philip J. Mease, Chitra Karki, Jacqueline B. Palmer et al. · 2017 · Arthritis Care & Research
Objective To characterize psoriatic arthritis (PsA) patients with dactylitis or enthesitis and evaluate the associations of these manifestations with disease activity and patient‐reported outcomes. Methods Using the Corrona…
View details →Negative / Null Result ReportOpen accessMedicine
Christine Desmedt, Roberto Salgado, Marco Fornili et al. · 2017 · JNCI Journal of the National Cancer Institute
Background: Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating the prevalence, levels, and composition of tumor-infiltrating…
View details →Negative / Null Result ReportOpen accessMedicine
Aysegül Ilhan‐Mutlu, Matthias Osswald, Yunxiang Liao et al. · 2016 · Molecular Cancer Therapeutics
Patients with nonsquamous non-small cell lung cancer (nsNSCLC; largely lung adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti-VEGF-A therapy may prevent the formation of nsNSCLC brain…
View details →Negative / Null Result ReportOpen accessMedicine
Vaibhav Sahai, Paul J. Catalano, Mark M. Zalupski et al. · 2018 · JAMA Oncology
Importance: Gemcitabine with platinum has limited efficacy for treatment of advanced cholangiocarcinoma, necessitating an evaluation of alternative drug combinations. Recent evidence suggests that paclitaxel may potentiate gemcitabine…
View details →Negative / Null Result ReportOpen accessMedicine
Isabel Holmbäck, Ulrika Ericson, Bo Gullberg et al. · 2010 · British Journal Of Nutrition
The role of eating frequency in obesity development is debated. Therefore, we investigated the association between eating frequency, BMI and waist circumference (WC), as well as how eating frequency is related to diet composition and…
View details →Negative / Null Result ReportOpen accessMedicine
Laura Salvador, Gunasekaran Singaravelu, Calvin B. Harley et al. · 2016 · Rejuvenation Research
TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 ± 180 bp; p = 0.005)
View details →Negative / Null Result ReportOpen accessMedicine
Harry Horsley, James Malone‐Lee, David Holland et al. · 2013 · PLoS ONE
Bacterial urinary tract infections (UTI) are a major growing concern worldwide. Uropathogenic Escherichia coli has been shown to invade the urothelium during acute UTI in mice and humans, forming intracellular reservoirs that can evade antibiotics and the immune response, allowing recurrence at a later date. Other bacterial species, such as Staphylococcus saprophyticus, Klebsiella pneumonia and Salmonella enterica have also been shown to be invasive in acute UTI. However, the role of intracellular infection in chronic UTI causing more subtle lower urinary tract symptoms (LUTS), a particular pr
View details →Negative / Null Result ReportOpen accessMedicine
Lingling Fang, Fangjian Guo, Lihua Zhou et al. · 2015 · Adipocyte
AIMS/HYPOTHESIS: Regional deposition of adipose tissue and adipocyte morphology may contribute to increased risk for insulin resistance. The aim of this study was to compare adipocyte cell size and size distribution from multiple fat…
View details →Failed Experiment ReportOpen accessMedicine
Laura Evgin, Amanda L. Huff, Phonphimon Wongthida et al. · 2020 · Nature Communications
The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial strategies to overcome immune suppression associated with the tumor microenvironment. Here we test whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells. Contrary to our hypothesis, VSVmIFNβ infection is associated with attrition of murine EGFRvIII CAR T cells in a B16EGFRvIII model, despite inducing a robust proinflam
View details →Negative / Null Result ReportOpen accessMedicine
Ji Min Choi, Jong In Yang, Seung Joo Kang et al. · 2018 · Journal of Neurogastroenterology and Motility
BACKGROUND/AIMS: The different clinical manifestations of gastroesophageal reflux disease (GERD) may be influenced by associated psychological factors. We evaluated the psychological status (anxiety and depression) according to each…
View details →Negative / Null Result ReportOpen accessMedicine
Athanassios Argiris, Michalis V. Karamouzis, William E. Gooding et al. · 2011 · Journal of Clinical Oncology
PURPOSE: We hypothesized that bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), will potentiate the activity of pemetrexed, a multitargeted antifolate, in squamous cell carcinoma of the head and neck…
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