Negative / Null Result ReportMedicine
Moira Strand Hutchinson, Guri Grimnes, Ragnar M. Joakimsen et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: Ecologic and observational studies have suggested an association between serum 25-hydroxyvitamin D (25(OH)D) levels and cardiovascular disease (CVD) risk factors, CVD mortality, and cancer mortality. Based on this, low serum…
View details →Negative / Null Result ReportOpen accessMedicine
Aletta P. I. Houwink, Saskia Rijkenberg, Rob J. Bosman et al. · 2016 · Critical Care
BACKGROUND: During resuscitation in severe sepsis and septic shock, several goals are set. However, usually not all goals are equally met. The aim of this study is to determine the relative importance of the different goals, such as mean arterial pressure (MAP), lactate, central venous oxygen saturation (ScvO2) and central to forefoot temperature (delta-T), and how they relate to intensive care unit (ICU) and hospital mortality. METHODS: In a retrospective cohort study in a 20-bed mixed medical and surgical ICU of a teaching hospital we studied consecutive critically ill patients who were admi
View details →Negative / Null Result ReportOpen accessMedicine
Adam C. Naj, Gary W. Beecham, Eden R. Martin et al. · 2010 · PLoS Genetics
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492 LOAD cases and 496 controls and from an independent set of 439 LOAD cases and 608 controls to strengthen power to identify novel genetic association signals. Associations exceeding the ex
View details →Negative / Null Result ReportOpen accessMedicine
Anja Laschkolnig, Barbara Kollerits, Claudia Lamina et al. · 2014 · Cardiovascular Research
AIMS: The relevance of lipoprotein(a) [Lp(a)] concentrations and low-molecular-weight (LMW) apo(a) phenotypes in peripheral arterial disease (PAD) has only been investigated by few studies. Therefore, we analysed this association in three…
View details →Negative / Null Result ReportOpen accessMedicine
Zvinka Z. Zlatar, Martha C. Muniz, Douglas Galasko et al. · 2016 · The Journals of Gerontology Series B
Objectives: Subjective cognitive decline (SCD) is common in older adults; however, its utility in clinic-based samples remains controversial given its strong associations with mood symptoms. Methods: Five hundred nineteen individuals aged…
View details →Negative / Null Result ReportOpen accessMedicine
Vijayvel Jayaprakash, Mihai Merzianu, Graham Warren et al. · 2013 · Head & Neck
BACKGROUND: The survival rates and prognostic factors for salivary duct carcinoma (SDC) are not clear. METHODS: Survival estimates and prognostic factors were evaluated for 228 patients with SDC identified from the Surveillance,…
View details →Negative / Null Result ReportOpen accessMedicine
Daniel Gelfond, Sonya L. Heltshe, Chang‐Xing Ma et al. · 2017 · Clinical and Translational Gastroenterology
OBJECTIVES: A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications in patients with cystic fibrosis (CF). We measured gastrointestinal pH, clinical outcomes, and intestinal transit profiles…
View details →Negative / Null Result ReportOpen accessMedicine
Mary Dankbaar, Jelmer Alsma, Els E. H. Jansen et al. · 2015 · Advances in Health Sciences Education
Simulation games are becoming increasingly popular in education, but more insight in their critical design features is needed. This study investigated the effects of fidelity of open patient cases in adjunct to an instructional e-module on students' cognitive skills and motivation. We set up a three-group randomized post-test-only design: a control group working on an e-module; a cases group, combining the e-module with low-fidelity text-based patient cases, and a game group, combining the e-module with a high-fidelity simulation game with the same cases. Participants completed questionnaires
View details →Negative / Null Result ReportMedicine
Laurence Lepage, A Dufour, Jessica Doiron et al. · 2015 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Hyperkalemia affects up to 10% of patients with CKD. Sodium polystyrene sulfonate has long been prescribed for this condition, although evidence is lacking on its efficacy for the treatment of mild hyperkalemia…
View details →Negative / Null Result ReportOpen accessMedicine
Padhma Ranganathan, Paul A. Clark, John S. Kuo et al. · 2011 · Journal of Virology
Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is a malignant and…
View details →Negative / Null Result ReportOpen accessMedicine
Zhongheng Zhang, Gensheng Zhang, Hemant Goyal et al. · 2018 · Critical Care
BACKGROUND AND OBJECTIVE: Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts of fluid resuscitation. METHODS: This was a retrospective study conducted in an intensive care unit at a large tertiary care hospital. The patients fulfilling the diagnostic criteria of sepsis from June 1, 2001 to October 31, 2012 were included. Clinical and laboratory variables were used to perform the latent profile analysis (LPA). A multivariable logistic regr
View details →Negative / Null Result ReportOpen accessMedicine
Nicholas J. Short, Naval Daver, Courtney D. DiNardo et al. · 2024 · Journal of Clinical Oncology
PURPOSE Azacitidine plus venetoclax is a standard of care for patients with newly diagnosed AML who are unfit for intensive chemotherapy. However, FLT3 mutations are a common mechanism of resistance to this regimen. The addition of…
View details →Negative / Null Result ReportOpen accessMedicine
Ignacio Illán‐Gala, Alberto Lleó, Anna Karydas et al. · 2020 · Neurology
OBJECTIVE: To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (FTLD-S) and clinically diagnosed…
View details →Negative / Null Result ReportOpen accessMedicine
Andrea B. Apolo, Karla V. Ballman, Guru Sonpavde et al. · 2024 · New England Journal of Medicine
BACKGROUND: Muscle-invasive urothelial carcinoma is an aggressive disease with high rates of relapse. Whether pembrolizumab as adjuvant therapy would be effective in patients with high-risk muscle-invasive urothelial carcinoma after…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaoyi Huang, Jian Zhao, Jinyi Bai et al. · 2019 · Journal of bone oncology
Osteosarcoma is the most common primary sarcoma of the bone. Lung osteosarcoma metastases at diagnosis have a significantly poor prognosis, even when surgery plus chemotherapy are performed. Our goal was to analyze clinical and sarcoma…
View details →Negative / Null Result ReportOpen accessMedicine
Sergio Livigni, Guido Bertolini, Carlotta Rossi et al. · 2014 · BMJ Open
OBJECTIVES: Coupled plasma filtration adsorption (CPFA, Bellco, Italy), to remove inflammatory mediators from blood, has been proposed as a novel treatment for septic shock. This multicenter, randomised, non-blinded trial compared CPFA…
View details →Negative / Null Result ReportOpen accessMedicine
María‐Victoria Mateos, Albert Oriol, Joaquín Martínez‐López et al. · 2012 · Blood
Maintenance therapy has become a hot field in myeloma, and it may be particularly relevant in elderly patients because the major benefit results from the initial therapy. We report the results of a randomized comparison of maintenance with…
View details →Negative / Null Result ReportOpen accessMedicine
Clara Montagut, Guillem Argilés, Fortunato Ciardiello et al. · 2018 · JAMA Oncology
IMPORTANCE: Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory patients…
View details →Negative / Null Result ReportMedicine
David S.P. Tan, Marjan Iravani, W. Glenn McCluggage et al. · 2011 · Clinical Cancer Research
PURPOSE: Ovarian clear cell carcinomas (OCCC) are a drug-resistant and aggressive type of epithelial ovarian cancer. We analyzed the molecular genetic profiles of OCCCs to determine whether distinct genomic subgroups of OCCCs exist.…
View details →Negative / Null Result ReportOpen accessMedicine
Rakesh Awasthi, Lida Pacaud, Edward Waldron et al. · 2020 · Blood Advances
The anti-CD19 chimeric antigen receptor (CAR)-T cell therapy tisagenlecleucel was evaluated in the global, phase 2 JULIET study in adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). We correlated…
View details →Negative / Null Result ReportMedicine
Mitchel Seruya, Mark Fisher, Eduardo D. Rodriguez · 2013 · Plastic & Reconstructive Surgery
BACKGROUND: There has been rising interest in computer-aided design/computer-aided manufacturing for preoperative planning and execution of osseous free flap reconstruction. The purpose of this study was to compare outcomes between…
View details →Negative / Null Result ReportOpen accessMedicine
Miquel Pujol, J. M. Miró, Evelyn Shaw et al. · 2020 · Clinical Infectious Diseases
BACKGROUND: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. METHODS: A randomized (1:1)…
View details →Negative / Null Result ReportMedicine
Joanna J. Wykrzykowska, Scot Garg, Yoshinobu Onuma et al. · 2011 · Circulation Cardiovascular Interventions
BACKGROUND: The age, creatinine, and ejection fraction (ACEF) score (age/left ventricular ejection fraction+1 if creatinine >2.0 mg/dL) has been established as an effective predictor of clinical outcomes in patients undergoing elective…
View details →Replication FailureOpen accessMedicine
Michelle Luciano, Janie Corley, Simon R. Cox et al. · 2017 · Neurology
OBJECTIVE: To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years). METHODS: We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline i
View details →Negative / Null Result ReportMedicine
Wim Van Paesschen, Édouard Hirsch, Martin Johnson et al. · 2012 · Epilepsia
PURPOSE: To evaluate the efficacy and tolerability of adjunctive brivaracetam (BRV), a novel high-affinity synaptic vesicle protein 2A ligand that also displays inhibitory activity at neuronal voltage-dependent sodium channels, in adult…
View details →Negative / Null Result ReportOpen accessMedicine
Timothy F. Cloughesy, Kevin Petrecca, Tobias Walbert et al. · 2020 · JAMA Oncology
Importance: New treatments are needed to improve the prognosis of patients with recurrent high-grade glioma. Objective: To compare overall survival for patients receiving tumor resection followed by vocimagene amiretrorepvec (Toca 511)…
View details →Negative / Null Result ReportOpen accessMedicine
Petra Langerbeins, Michael Hallek · 2022 · Blood
The coronavirus infectious disease (COVID-19) shows a remarkable symptomatic heterogeneity. Several risk factors including advanced age, previous illnesses, and a compromised immune system contribute to an unfavorable outcome. In patients…
View details →Negative / Null Result ReportOpen accessMedicine
Yukinori Kurokawa, Mitsuru Sasako, Takeshi Sano et al. · 2015 · British journal of surgery
BACKGROUND: The optimal surgical approach for treatment of oesophagogastric junction (OGJ) cancer is controversial. A randomized clinical trial (JCOG9502) comparing transhiatal (TH) and left thoracoabdominal (LTA) approaches was stopped…
View details →Negative / Null Result ReportOpen accessMedicine
Floris Dammeijer, Lysanne A. Lievense, Margaretha E. Kaijen-Lambers et al. · 2017 · Cancer Immunology Research
Abstract New immunotherapeutic strategies are needed to induce effective antitumor immunity in all cancer patients. Malignant mesothelioma is characterized by a poor prognosis and resistance to conventional therapies. Infiltration of…
View details →Negative / Null Result ReportOpen accessMedicine
Daniel J. Renouf, Jonathan M. Loree, Jennifer J. Knox et al. · 2022 · Nature Communications
Immunotherapy-based monotherapy treatment in metastatic pancreatic ductal adenocarcinoma (mPDAC) has shown limited benefit outside of the mismatch repair deficiency setting, while safety and efficacy of combining dual-checkpoint inhibitor immunotherapy with chemotherapy remains uncertain. Here, we present results from the CCTG PA.7 study (NCT02879318), a randomized phase II trial comparing gemcitabine and nab-paclitaxel with and without immune checkpoint inhibitors durvalumab and tremelimumab in 180 patients with mPDAC. The primary endpoint was overall survival. Secondary endpoints included pr
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