12,244 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Yang Z, Pajuste FD, Zguro K et al. · 2025 · Nature genetics
Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with…
View details →Horton CB Jr, Adam H, Galinsky AD · 2025 · Personality & social psychology bulletin
Enclothed cognition refers to the systematic influence that clothes can have on the wearer's feelings, thoughts, and behaviors through their symbolic meaning. It has attracted considerable academic and nonacademic interest, with the 2012…
View details →Chen TA, Chuang YT, Pai SC et al. · 2025 · Microorganisms
Ventilator-associated pneumonia (VAP) remains a significant concern in intensive care units (ICUs), contributing to increased morbidity, mortality, and healthcare costs. Probiotics and synbiotics have been explored as potential preventive…
View details →Alben N, Arthur C · 2024 · Attention, perception & psychophysics
In the present paper, we carry out a replication of a seminal paper by Kahneman, D. & Beatty, J. (1967). Perception & Psychophysics, 2(3),101-105 for using pupillometry as an implicit measure of auditory processing load, specifically,…
View details →Aicoboaie S, Pappaianni E, Abdulkadir M et al. · 2025 · Psychological medicine
Background Shared genetic risk has been shown across psychiatric disorders. In particular, anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and schizophrenia (SCZ) show shared genetic risk that matches clinical evidence of…
View details →Bechtel GN, Kostelnik CJ, Rausch MK · 2025 · Journal of biomedical materials research. Part A
Tissue mimicking materials are designed to represent real tissue in applications such as medical device testing and surgical training. Thanks to progress in 3D-printing technology, tissue mimics can now be easily cast into arbitrary…
View details →Saladini F, Giannini A, Giammarino F et al. · 2026 · Open forum infectious diseases
Background HIV-1 sub-subtype A6 is predominant in Eastern Europe and was associated with increased risk of treatment failure with the long-acting cabotegravir plus rilpivirine regimen. In this study, we aimed to evaluate the in vitro…
View details →Hoth KF, Voorhies K, Wu AC et al. · 2022 · Journal of psychiatry and brain science
Depression is the most common mental illness in the U.S. affecting nearly 40 million adults age 18 years and older. Depression has both genetic and environmental influences. In addition, women are more likely to be affected by depression…
View details →Davis CN, Jinwala Z, Justice AC et al. · 2025 · Alcohol, clinical & experimental research
Background Topiramate reduces alcohol consumption in individuals who drink heavily. Candidate gene studies aimed at identifying genetic variants that predict topiramate's effects on drinking have yielded inconsistent findings. To identify…
View details →Bender O, Shemesh OA, Bar DZ · 2026 · Journal of Alzheimer's disease : JAD
The etiology of Alzheimer's disease (AD) remains a subject of intense investigation. While the 2024 Lancet Commission report attributes approximately 45% of global dementia cases to 14 modifiable risk factors, it notably excludes…
View details →Ruuskanen V, Hagen T, Espeseth T et al. · 2024 · Journal of cognition
Over the past few years, several studies have explored the relationship between resting-state baseline pupil size and cognitive abilities, including fluid intelligence, working memory capacity, and attentional control. However, the results…
View details →Baldé AM, Schellenberg EG, Lima CF · 2026 · Psychonomic bulletin & review
Why does musical expertise predict enhanced emotion recognition in speech prosody? Evidence for a causal role of music training is weak, and correlations with musical aptitude could reflect basic auditory abilities rather than musicality…
View details →Beckner AG, Voss AT, Phillips L et al. · 2023 · Infant behavior & development
Two experiments were conducted to examine mental rotation in 6- to 12-month-old infants (N = 166) using a change detection task. These experiments were replications of Lauer and Lourenco (Lauer et al., 2015; Lauer & Lourenco, 2016), using…
View details →Abad-Malo D, Alvarado-Cando O, Karsilar H · 2025 · Journal of eye movement research
Our interaction with the world depends on our ability to process temporal information, which is a key component of human cognition that directly impacts decision-making, planning, and prediction of events. Visual information plays a…
View details →Lorente P, Ruuskanen V, Mathôt S et al. · 2025 · Psychonomic bulletin & review
Recent studies have investigated resting-state, or baseline, pupil size as a general measure of cognitive abilities, based on the earlier finding that larger pupils might be predictive of higher general intelligence or working memory…
View details →Van der Burg E, Jertberg RM, Geurts HM et al. · 2026 · Translational psychiatry
Traditional subjective measures are limited in the insight they provide into underlying behavioral differences associated with autism and, accordingly, their ability to predict diagnosis. Performance-based measures offer an attractive…
View details →Ashburn-Nardo L, Moss-Racusin CA, Smith JL et al. · 2022 · Frontiers in psychology
The reproducibility movement in psychology has resulted in numerous highly publicized instances of replication failures. The goal of the present work was to investigate people's reactions to a psychology replication failure vs. success,…
View details →Mura F, Catrambone V, Valenza G et al. · 2026 · Biological psychiatry global open science
Background Various cognitive and emotional factors shape our perception of time. Notably, individuals experiencing depressive symptoms often report changes in their time perception, characterized by a phenomenon termed depressive time…
View details →Hawkes JA, Flygare AD, Moodie LWK et al. · 2025 · Analytical chemistry
Dissolved organic matter (DOM) is one of the most complex chemical mixtures known, with its chemical composition having long puzzled biogeochemists. Identifying the chemical structures within DOM is essential for unraveling its origins and…
View details →Galvin HR, Boffo M, Snippe L et al. · 2023 · Addictive behaviors
Evidence for approach bias tendencies to underly automatic behavioural impulses towards seeking out gambling activities in the presence of appetitive salient cues was first shown by Boffo et al. (2018) in a Dutch sample. Relative to…
View details →Hashemi Tayer A, Shokoohi G · 2026 · Iranian journal of microbiology
Background and objectives Umbilical cord blood-derived platelet gel (CBPG) is rich in growth factors (GFs) and antimicrobial peptides. This study evaluated its in vitro antibacterial and antifungal activity against dominant nosocomial…
View details →Landolt MA, Strebel NL, Moehrlen U et al. · 2026 · Epigenetics
Fetal repair of spina bifida aperta (fSBA) is an established intervention that improves neurological and neurodevelopmental outcomes. The present exploratory study examines whether molecular signatures related to stress regulation are…
View details →Stump K, Morar H, Talsania A et al. · 2026 · Hand (New York, N.Y.)
Background Glucagon-like peptide-1 receptor agonist (GLP-1 RA) use has demonstrated positive effects on bone metabolism and pseudoarthrosis following fusion surgery. There is, however, little evidence regarding the preoperative use of…
View details →Egeskov-Cavling AM, van Wijhe M, Yakimov V et al. · 2024 · The Journal of infectious diseases
Background Worldwide, respiratory syncytial virus (RSV) infections are among the most common causes of infant hospitalization. Host genetic factors influencing the risk and severity of RSV infection are not well known. Methods We conducted…
View details →Tan E, Williams HC · 2026 · American journal of clinical dermatology
Nicotinamide has been widely promoted as a low-cost safe chemopreventive agent against non-melanoma skin cancer. A recent large retrospective study of more than 33,000 US veterans reported a 14% reduction in overall skin cancer risk and a…
View details →Lien MC, Ruthruff E · 2023 · Journal of cognition
There is emerging evidence that suppressing distractors occur to prevent capture by those distractors. Theeuwes (2022) claimed that the absence of capture is not because of suppression but rather because a difficult, serial search causes…
View details →Mochizuki M · 2022 · Cognitive processing
The QWERTY effect is a phenomenon in which words typed with more characters from the right side (everything to the right of T, G, and B) of a standard keyboard (i.e. QWERTY keyboard) are evaluated as having a higher valence or a more…
View details →Famularo RL, Aboelata A, Schatz T et al. · 2026 · Developmental science
Human newborns are able to discriminate between certain languages but not others. This ability has long been attributed to sensitivity to rhythm-the temporal regularities in speech of different languages. Here, we demonstrate through a…
View details →Warman A, Clark A, Malcolm GL et al. · 2024 · Quarterly journal of experimental psychology (2006)
It's been repeatedly shown that pictures of graspable objects can facilitate visual processing, even in the absence of reach-to-grasp actions, an effect often attributed to the concept of affordances. A classic demonstration of this is the…
View details →Melton ZJ, Chaffin R, Kangas-Dick K et al. · 2023 · Quarterly journal of experimental psychology (2006)
The causal relationship of interpersonal liking affecting interpersonal synchrony is inconsistently documented. This study tests whether (a) interpersonal liking increases both behavioural and perceived synchrony and (b) people will…
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