12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Meeta Prasad Kerlin, Dylan S. Small, Elizabeth Cooney et al. · 2013 · New England Journal of Medicine
BACKGROUND: Increasing numbers of intensive care units (ICUs) are adopting the practice of nighttime intensivist staffing despite the lack of experimental evidence of its effectiveness. METHODS: We conducted a 1-year randomized trial in an…
View details →Alisa J. Prager, Nina Martinez, Kathryn Beal et al. · 2015 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Treatment-related changes and recurrent tumors often have overlapping features on conventional MR imaging. The purpose of this study was to assess the utility of DWI and DSC perfusion imaging alone and in combination to differentiate treatment-related effects and recurrent high-grade gliomas. MATERIALS AND METHODS: We retrospectively identified 68 consecutive patients with high-grade gliomas treated by surgical resection followed by radiation therapy and temozolomide, who then developed increasing enhancing mass lesions indeterminate for treatment-related changes versus
View details →Nevert Badreldin, William A. Grobman, Lynn M. Yee · 2019 · Obstetrics and Gynecology
OBJECTIVE: To evaluate racial and ethnic differences in women's postpartum pain scores, inpatient opioid administration, and discharge opioid prescriptions. METHODS: We conducted a retrospective cohort study of all deliveries at a single…
View details →Lee Fong Ling, Thomas H. Marwick, Demetrio Roland Flores et al. · 2013 · Circulation Cardiovascular Imaging
BACKGROUND: Although the recent surgical treatment of ischemic heart failure substudy reported that revascularization of viable myocardium did not improve survival, these results were limited by the viability imaging technique used and the…
View details →F. Perry Wilson, Melissa Martin, Yu Yamamoto et al. · 2021 · BMJ
Abstract Objective To determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression of acute kidney injury. Design Double blinded, multicenter, parallel,…
View details →US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA
Importance: Breast cancer is the most common nonskin cancer among women in the United States and the second leading cause of cancer death. The median age at diagnosis is 62 years, and an estimated 1 in 8 women will develop breast cancer at…
View details →Elena Myasoedova, Cynthia S. Crowson, Carl Turesson et al. · 2011 · The Journal of Rheumatology
OBJECTIVE: To assess incidence and mortality effects of extraarticular rheumatoid arthritis (ExRA) in patients with incident RA in 1995-2007 compared to 1985-1994, in Olmsted County, Minnesota, USA. METHODS: Data on incident ExRA were…
View details →Tony Mok, Sang‐We Kim, Yi‐Long Wu et al. · 2017 · Journal of Clinical Oncology
Purpose The Iressa Mutation-Positive Multicentre Treatment Beyond ProgRESsion Study (IMPRESS) compared the continuation of gefitinib plus chemotherapy with placebo plus chemotherapy in patients with epidermal growth factor receptor ( EGFR)…
View details →Benjamin Gravesteijn, Daan Nieboer, Ari Ercole et al. · 2020 · Journal of Clinical Epidemiology
OBJECTIVE: We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. STUDY DESIGN AND SETTING: We performed logistic regression (LR), lasso…
View details →Stephan Willems, Roland Richard Tilz, Daniel Steven et al. · 2020 · Circulation
Background: Catheter ablation for ventricular tachycardia (VT) reduces the recurrence of VT in patients with implantable cardioverter-defibrillators (ICDs). The appropriate timing of VT ablation and its effects on mortality and heart…
View details →Nina Johnston, Johan Bodegård, Susanna Jerström et al. · 2016 · American Heart Journal
BACKGROUND: Patients with myocardial infarction (MI) seldom reach recommended targets for secondary prevention. This study evaluated a smartphone application ("app") aimed at improving treatment adherence and cardiovascular lifestyle in MI…
View details →Shannon Fraser, Paul A. Gardner, Maria Koutourousiou et al. · 2017 · Journal of neurosurgery
OBJECTIVE The aim in this paper was to determine risk factors for the development of a postoperative CSF leak after an endoscopic endonasal approach (EEA) for resection of skull base tumors. METHODS A retrospective review of patients who…
View details →Adam M. Lee, Qian Shi, Emily S. Pavey et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Previous studies have suggested the potential importance of three DPYD variants (DPYD*2A, D949V, and I560S) with increased 5-FU toxicity. Their individual associations, however, in 5-FU-based combination therapies, remain…
View details →Roham T. Zamanian, David B. Badesch, Lorinda Chung et al. · 2021 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Systemic sclerosis (SSc)–pulmonary arterial hypertension (PAH) is one of the most prevalent and deadly forms of PAH. B cells may contribute to SSc pathogenesis. Objectives We investigated the safety and efficacy of…
View details →Angela Kuznia, Anita K Hernandez, Lydia U Lee · 2020 · PubMed
Adolescent idiopathic scoliosis affects 1% to 3% of U.S. adolescents. It is defined by a lateral curvature of the spine (Cobb angle) of at least 10 degrees in the absence of underlying congenital or neuromuscular abnormalities. Adolescent…
View details →Peter Sundström, Anders Wåhlin, Khalid Ambarki et al. · 2010 · Annals of Neurology
The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we studied 21 relapsing-remitting multiple sclerosis cases and…
View details →DK Patel, R Kumar, SK Prasad et al. · 2011 · Asian Pacific Journal of Tropical Biomedicine
OBJECTIVE: To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models. METHODS: The oral glucose tolerance test (OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus (AHE) were…
View details →Myung‐Ju Ahn, Kentaro Tanaka, Luis Paz‐Ares et al. · 2024 · Journal of Clinical Oncology
PURPOSE The randomized, open-label, global phase III TROPION-Lung01 study compared the efficacy and safety of datopotamab deruxtecan (Dato-DXd) versus docetaxel in patients with pretreated advanced/metastatic non–small cell lung cancer…
View details →Ilaria Montagni, Elie Guichard, Claire Carpenet et al. · 2015 · Cephalalgia
Objective The objective of this article is to investigate whether excessive screen time exposure is associated with non-migraine headache and migraine in young adults. Background Increased levels of television time have been associated…
View details →Miriam M. Boxer, Shalini Vinod, Jesmin Shafiq et al. · 2011 · Cancer
BACKGROUND: There is limited evidence regarding the effectiveness of multidisciplinary team (MDT) meetings in lung cancer. The objective of this study was to compare the patterns of care for patients with newly diagnosed lung cancer who…
View details →Ranjani R. Starr · 2015 · American Journal of Public Health
Millions of people in the United States consume dietary supplements hoping to maintain or improve their health; however, extensive research has failed to demonstrate the efficacy of numerous supplements in disease prevention. In addition,…
View details →J. F. Keating, Elizabeth Will · 2011 · Journal of Bone and Joint Surgery - British Volume
A total of 80 patients with an acute rupture of tendo Achillis were randomised to operative repair using an open technique (39 patients) or non-operative treatment in a cast (41 patients). Patients were followed up for one year. Outcome…
View details →Robert H. Squires, Anil Dhawan, Estella M. Alonso et al. · 2012 · Hepatology
UNLABELLED: N-acetylcysteine (NAC) was found to improve transplantation-free survival in only those adults with nonacetaminophen (non-APAP) acute liver failure (ALF) and grade 1-2 hepatic encephalopathy (HE). Because non-APAP ALF differs…
View details →Armin Zittermann, Jana B. Ernst, Sylvana Prokop et al. · 2017 · European Heart Journal
AIMS: Circulating 25-hydroxyvitamin D (25OHD) levels <75 nmol/L are associated with a nonlinear increase in mortality risk. Such 25OHD levels are common in heart failure (HF). We therefore examined whether oral vitamin D supplementation…
View details →Siaw Cheok Liew, Esha Dasgupta, Shew Fung Wong et al. · 2012 · Nutrition Journal
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels. METHODS: This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fa
View details →Mengyue Niu, Yang Li, Gerald Li et al. · 2020 · European Journal of Neurology
BACKGROUND AND PURPOSE: The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exosomes as a…
View details →US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Skin cancer is the most common type of cancer in the United States. Although invasive melanoma accounts for only 2% of all skin cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma,…
View details →Charles Pilgrim, Richard McIntyre, Michael Bailey · 2010 · Diseases of the Colon & Rectum
PURPOSE: There is little evidence regarding the prevalence or incidence of parastomal hernia, but it is thought to be common. Repair of parastomal hernia can be troublesome, and methods of repair need to be validated based on reduced…
View details →Farzana Saleh, Shirin Jahan Mumu, Ferdous Ara et al. · 2014 · BMC Public Health
BACKGROUND: Non-adherence to lifestyle modification among diabetic patients develops the short-term risks and the long-term complications as well as declines the quality of life. This study aimed to find out the association between non-adherence to self-care practices, medication and health related quality of life (HR-QoL) among type 2 diabetic patients. METHODS: At least 1 year diagnosed patients with type 2 diabetes (N = 500), age>25 years were conveniently selected from the Out-Patient Department of Bangladesh Institute of Health Sciences Hospital. Patients' self-care practices were assesse
View details →Maximilian Christopeit, Oliver Kuß, Jürgen Finke et al. · 2013 · Journal of Clinical Oncology
PURPOSE: To evaluate the role of a second allogeneic hematopoietic stem-cell transplantation (HSCT2) given for relapsed acute leukemia (AL) after related or unrelated first hematopoietic stem-cell transplantation (HSCT1) and to analyze the…
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