Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Multicenter, Double-Blind, Randomized, Placebo-controlled Trial
Roham T. Zamanian; David B. Badesch; Lorinda Chung; Robyn T. Domsic; Thomas A. Medsger; Ashley Pinckney; Lynette Keyes-Elstein; Carla D’Aveta · 2021 · American Journal of Respiratory and Critical Care Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Abstract Rationale Systemic sclerosis (SSc)–pulmonary arterial hypertension (PAH) is one of the most prevalent and deadly forms of PAH. B cells may contribute to SSc pathogenesis. Objectives We investigated the safety and efficacy of…
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Metadata source: OpenAlex · DOI 10.1164/rccm.202009-3481oc