DPYD Variants as Predictors of 5-fluorouracil Toxicity in Adjuvant Colon Cancer Treatment (NCCTG N0147)
Adam M. Lee; Qian Shi; Emily S. Pavey; Steven R. Alberts; Daniel J. Sargent; Frank A. Sinicrope; Jeffrey L. Berenberg; Richard M. Goldberg · 2014 · JNCI Journal of the National Cancer Institute
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: Previous studies have suggested the potential importance of three DPYD variants (DPYD*2A, D949V, and I560S) with increased 5-FU toxicity. Their individual associations, however, in 5-FU-based combination therapies, remain…
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Metadata source: OpenAlex · DOI 10.1093/jnci/dju298