Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jong Won Shin, Minh Nguyen Thien, Sun Ha Jee · 2025 · Healthcare
Background: Bilirubin is a potent endogenous antioxidant that plays a key role in regulating oxidative stress and inflammation, both closely linked to lung carcinogenesis. This study reinterprets the ALBI (Albumin–Bilirubin) and PALBI (Platelet–Albumin–Bilirubin) indices as composite markers of antioxidant and inflammatory status and evaluates their associations with lung cancer risk by sex, including stratified analyses by major lifestyle factors such as smoking and alcohol use. Methods: This study utilized data from the Korean Cancer Prevention Study-II (KCPS-II) cohort, which included 133,6
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Borbála Turcsán, Dorottya Júlia Ujfalussy, Andrea Kerepesi et al. · 2025 · Scientific Reports
Most dog owners in Western countries regard their dogs as companions or family members, prompting extensive research on the human-animal bond. However, many studies rely on broad categories or single dimensions, such as satisfaction or attachment, which can oversimplify the complexity of these relationships. In contrast, our study employed a multifaceted approach, examining the dog-owner bond across 13 relationship scales and comparing these scales to four different types of human relationships to reveal the human-like roles of dogs within a family. Participants (N = 717) characterized their r
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras et al. · 2026 · Nature Medicine
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome. In multivariable confounder-adjusted regression models, antibiotic use <1 year before fecal sampling was associated with the greatest reduction in species diversity, but significant asso
View details →Replication FailureBiochemistry, Genetics and Molecular Biology
Jérôme Paul, Michel Verleysen, Pierre Dupont · 2013
Abstract. Embedded feature selection can be performed by analyzing the variables used in a Random Forest. Such a multivariate selection takes into account the interactions between variables but is not easy to interpret in a statistical…
View details →Abandoned HypothesisBiochemistry, Genetics and Molecular Biology
Kirstin R.W. Matthews, Ana S. Iltis · 2019 · Accountability in Research
After the announcement that a scientist genetically altered human embryos and implanted them for gestation last November, the increased discussion has revolved around the ethical lapses that occurred in the process. The scientist, He…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sami Alobaidi · 2025 · Frontiers in Medicine
Chronic kidney disease (CKD) remains a major global health issue, affecting millions and presenting persistent diagnostic and therapeutic challenges. Conventional biomarkers such as serum creatinine and estimated glomerular filtration rate have well-recognized limitations, underscoring the need for novel diagnostic tools and interventions. Emerging evidence highlights the gut-kidney axis as a central contributor to CKD pathogenesis, shaped by microbial dysbiosis and altered metabolite production. Harmful metabolites such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide promote
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Sukeshi Patel Arora, Laura Tenner, John Sarantopoulos et al. · 2019 · Journal of Clinical Oncology
3551 Background: Agents targeting the angiogenic pathway have been a cornerstone therapy in mCRC. In chemo-refractory mCRC, RGF, an oral multikinase inhibitor with considerable angiogenic inhibition, has shown modest effects on survival.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhongwei Liu, Shuang Shi, Haitao Zhu et al. · 2018 · International Heart Journal
The phenotype shifting of vascular smooth muscle cells (VSMCs) was indicated to play a role during the initial stage of atherosclerotic plaque formation by facilitating extracellular matrix deposition. This study was aimed at investigating…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Amalie Kjær Andresen, Mathilde Sophie Felding, Margarida M. A. Sacramento et al. · 2025 · Journal of Controlled Release
Bacterial biofilms pose a significant clinical challenge due to their intrinsic resistance to antibiotics and immune clearance. Traditional systemic antibiotic therapies are often ineffective against the structured microbial communities, emphasizing the urgent need for localized and targeted drug delivery systems. Hydrogels are three-dimensional, water-rich polymeric networks, and have emerged as a versatile platform for localized delivery of antimicrobial agents, offering controlled release, biocompatibility and the potential for functionalization with bioactive components. This review explor
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sk. Kayum Alam, Li Wang, Zhu Zhu et al. · 2023 · npj Precision Oncology
Non-small cell lung cancer (NSCLC) accounts for 80-85% cases of lung cancer cases. Diagnosis at advanced stages is common, after which therapy-refractory disease progression frequently occurs. Therefore, a better understanding of the molecular mechanisms that control NSCLC progression is necessary to develop new therapies. Overexpression of IκB kinase α (IKKα) in NSCLC correlates with poor patient survival. IKKα is an NF-κB-activating kinase that is important in cell survival and differentiation, but its regulation of oncogenic signaling is not well understood. We recently demonstrated that IK
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marcin A. Sowa, Haoyu Sun, Tricia T. Wang et al. · 2024 · JACC Basic to Translational Science
We investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y12 inhibitor, platelets from healthy volunteers receiving aspirin or…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eva S. M. van der Heijden, Karin Näsvall, Fernando Seixas et al. · 2025 · Proceedings of the National Academy of Sciences
A central question in evolutionary biology is what drives the diversification of lineages. Rapid, recent radiations are ideal systems for this question because they still show key morphological and ecological adaptations associated with speciation. While most research on recent radiations focuses on those occurring in insular environments, less attention has been given to continental radiations with complex species interactions. Here, we study the drivers of continental radiations of Melinaea and Mechanitis butterflies (Nymphalidae: Ithomiini), which have rapidly radiated in the continental Ne
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dana Lengel, Paul J. Kenny · 2023 · Addiction Neuroscience
Diseases associated with nicotine dependence in the form of habitual tobacco use are a major cause of premature death in the United States. The majority of tobacco smokers will relapse within the first month of attempted abstinence.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sven E. Weber, Harmeet Singh Chawla, Lennard Ehrig et al. · 2023 · Frontiers in Plant Science
In modern plant breeding, genomic selection is becoming the gold standard to select superior genotypes in large breeding populations that are only partially phenotyped. Many breeding programs commonly rely on single-nucleotide polymorphism (SNP) markers to capture genome-wide data for selection candidates. For this purpose, SNP arrays with moderate to high marker density represent a robust and cost-effective tool to generate reproducible, easy-to-handle, high-throughput genotype data from large-scale breeding populations. However, SNP arrays are prone to technical errors that lead to failed al
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Pengfei Fu, Xijie Li, Zhongxiang Sun et al. · 2025 · Evolutionary Applications
As a migratory agricultural pest, the fall armyworm has been in the spotlight since it invaded Africa in 2016. Invasive populations have now colonized much of the Eastern Hemisphere, causing severe damage to a wide range of crops. However, there is still disagreement internationally on the origin and mode of invasion of fall armyworm populations, especially from the Americas to China. In this study, we provided an in-depth insight into the invasion of the fall armyworm in the Eastern hemisphere based on genome-wide data from 124 fall armyworm individuals collected from 14 sites across three co
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Korenjak, Nuri A. Temiz, Stéphane Keïta et al. · 2026 · Genome Medicine
BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Pamela J. Kaisaki, Georg Otto, Karène Argoud et al. · 2016 · G3 Genes Genomes Genetics
Abstract To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (BN) controls, which contain well-defined blocks (1–183 Mb) of genetic polymorphisms, and in 123 genetically heterogeneous rats of an (GK × BN)F2 offspring. Within each congenic we identified 73–1351 differentially expressed genes (DEGs), only 7.7% of which mapped within the congenic blocks, and which may be regulated in cis. The remai
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chunmei Cai, Guohua Ni, Lei Chen et al. · 2026 · Signal Transduction and Targeted Therapy
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a cascade of physiological responses. However, inadequate or excessive responses can lead to malacclimatization, resulting in hypoxemia and various high-altitude illnesses, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and high-altitude pulmonary hy
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Efrain Ricardo Torres, Jennifer Wilcox, W. H. Wilson Tang · 2025 · Gut Microbes
Trimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease. Gut microbes produce trimethylamine (TMA) moieties from common dietary precursors, such as choline or carnitine, which are subsequently metabolized by the liver into TMAO. Circulating TMAO then exerts various effects, influencing dyslipidemia, metabolic syndrome, endothelial dysfunction, and inflammation, as well as other detrimental processes. Many existing medications have been shown to decrease TMAO levels
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Andrew J. Steward, Daniel J. Kelly, Diane R. Wagner · 2016 · Tissue Engineering Part A
Although hydrostatic pressure (HP) is known to regulate chondrogenic differentiation of mesenchymal stromal/stem cells (MSCs), improved insight into the mechanotransduction of HP may form the basis for novel tissue engineering strategies.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yi-Lun Ge, Pu-Zhi Wang, Jia-Hui Yan et al. · 2022 · Advanced Neurology
Hyposmia is one of the cardinal symptoms of Parkinson&rsquo;s disease (PD), with a considerably high prevalence rate in PD individuals. However, some individuals still retain normal olfactory function. Recent studies have shown that genetic factors may play a role in such a phenomenon. This study aimed to explore the potential genetic factors underlying the variation of olfactory function among PD individuals. Two hundred and three Han Chinese individuals with PD were recruited into this study. All the individuals underwent detailed clinical assessment conducted by experienced neurologists
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yuko Shimizu‐Motohashi · 2025 · Brain and Development
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by variants of the DMD that leads to progressive muscle degeneration. Recent advances in gene therapy have opened new therapeutic avenues, particularly through the use of adeno-associated virus (AAV)-mediated micro-dystrophin delivery. Delandistrogene moxeparvovec, the first FDA-approved gene therapy for DMD, has demonstrated transgene expression and potential functional improvement in early phase trials, although its long-term efficacy, durability, and safety remain unconfirmed. Immune-mediated toxicities including
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna Barton, Maciej Jaśkiewicz, Anna Więch -Walów et al. · 2025 · Cell Communication and Signaling
Abstract The cellular and tissue response to acute hypoxia is mediated by a complex adaptive response initiated by hypoxia-inducible factors (HIF) 1 and 2. HIF proteins are key transcription factors that modulate gene expression to adapt cells to the low oxygen tension. Cellular studies of hypoxia have used the low oxygen model by using hypoxia chambers to monitor the gene expression changes, while others have utilized hypoxia mimetics in normoxic conditions. Here, we provide a comparison of the utility and limitations of two hypoxia mimetics by studying the changes in the miRNA and mRNA expre
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Breanne Cuddington, Meghan L. Verschoor, Ali A. Ashkar et al. · 2015 · Molecular Therapy — Oncolytics
Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the…
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