BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study
Robert Massey; Yu Chen; Marina Panova‐Noeva; Michaela Mattheus; Moneeza K. Siddiqui; Nanette C. Schloot; Antonio Ceriello; Ewan R. Pearson · 2024 · Cardiovascular Diabetology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: BMI variability has been associated with increased cardiovascular disease risk in individuals with type 2 diabetes, however comparison between clinical studies and real-world observational evidence has been lacking. Furthermore, it is not known whether BMI variability has an effect independent of HbA1c variability. METHODS: We investigated the association between BMI variability and 3P-MACE risk in the Harmony Outcomes trial (n = 9198), and further analysed placebo arms of REWIND (n = 4440) and EMPA-REG OUTCOME (n = 2333) trials, followed by real-world data from the Tayside Bioreso
Abstract by Robert Massey; Yu Chen; Marina Panova‐Noeva; Michaela Mattheus; Moneeza K. Siddiqui; Nanette C. Schloot; Antonio Ceriello; Ewan R. Pearson, Cardiovascular Diabetology (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12933-024-02299-8