12,375 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Serrano, Gueugneau, Ravier · 2026 · Scientific reports
This study examined modulations of the cardiac autonomic nervous system, neuromuscular performance and psychological states during the menstrual cycle (MC) in naturally menstruating women. Fifteen healthy young females were tested during…
View details →Kitahara, Ohshima, Nakajima et al. · 2026 · Scientific reports
Full-endoscopic spine surgery performed under local anesthesia offers clinical advantages, particularly for elderly patients. However, its reliance on fluoroscopy raises concerns about occupational radiation exposure. Although several…
View details →da Silva, Alves, Jalkh et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials
To evaluate microbial inhibition at the implant-abutment interface of 5Y-PSZ zirconia abutments coated with boron-doped soda-lime glass, with or without silver, and to evaluate the fatigue lifetime of boron-doped soda-lime glass-coated…
View details →Shang, Ma, Chen et al. · 2026 · Waste management (New York, N.Y.)
Ammonia (NH 3 ) is a key odorous gas emitted from livestock and poultry farming, and biofiltration has been widely used for NH 3 removal. Temperature plays a critical role in regulating microbial activity and greenhouse gas emissions in…
View details →Zhou, He, Cheng et al. · 2026 · CNS neuroscience & therapeutics
To compare the real-world effectiveness, surgical and economic outcomes of preoperative rapid antibody clearance therapy (RACT: lymphoplasmapheresis (LPE), efgartigimod (EFG)) versus oral immunosuppressants (Oral IS) in generalized…
View details →Fukuda, Blackwood, Kim et al. · 2026 · Journal of neurointerventional surgery
Combined delivery catheter systems (CDCS) with ledge-reducing obturators are designed to streamline aspiration-first mechanical thrombectomy, yet comparative multicenter data across platforms remain limited. To determine whether an…
View details →Giorgini, Xavier, da Silva et al. · 2026 · Topics in companion animal medicine
LINE-1 (long interspersed nuclear element-1) is a family of related class I transposable elements in the DNA that is dispersed throughout the entire genome and the study of its methylation pattern is used in the understanding of several…
View details →Tran, Padda, Sharma et al. · 2026 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
A major challenge in teaching slit-lamp biomicroscopy is providing adequate depth perception and anatomical detail; the Deep Reality Viewer (DRV) addresses this by enabling stereopsis. This study evaluated the utility of DRV for slit-lamp…
View details →Björkman, Malusek, Persson et al. · 2026 · European radiology experimental
The aim was to compare the image quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT) in patients with tibial plateau fractures treated with metallic osteosynthesis material, and to identify optimal…
View details →Michael R Gionfriddo, Yirui Hu, Bhumika Maddineni et al. · 2022 · JMIR Formative Research
BackgroundDespite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources. ObjectiveWe aim to evaluate th
View details →A. J. Oswald, R. L. Hollis, M. Churchman et al. · 2026 · Scientific Reports
Abstract Copy number loss (CNL) of tumour suppressors genes, such as BRCA1/2, are frequent but under-researched tumour driver events. Accurate identification of BRCA1/2 CNL has potential therapeutic implications, particularly in high grade serous tubo-ovarian carcinoma (HGSOC), and cost-effective detection methods are desirable. This study assessed quantitative PCR (qPCR) as a method of BRCA1/2 CNL detection in HGSOC, in two patient cohorts (cohort 1 n = 355, cohort 2 n = 86) and a cell line panel (n = 10) using sequencing-based copy number (CN) assessment as a comparator (panel-based sequenci
View details →A. Bühler, Johannes Thrul, Evelin Strüber et al. · 2015 · Health Promotion International
Because of scarce research, the effectiveness of substance abuse prevention in leisure settings remains unclear. In this study, we evaluated the effectiveness of a peer-led educational prevention measure with adolescent groups in…
View details →David J. Harris, Shawn D. Taylor, Ethan P. White · 2018 · PeerJ
Biodiversity forecasts are important for conservation, management, and evaluating how well current models characterize natural systems. While the number of forecasts for biodiversity is increasing, there is little information available on how well these forecasts work. Most biodiversity forecasts are not evaluated to determine how well they predict future diversity, fail to account for uncertainty, and do not use time-series data that captures the actual dynamics being studied. We addressed these limitations by using best practices to explore our ability to forecast the species richness of bre
View details →Cláudia Saraiva, Daniela Talhada, Akhilesh Rai et al. · 2018 · PLoS ONE
There is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro and in vivo model of stroke. For that, neuroprotective and neurogenic responses were assessed in an in vitro model of stroke. Here, we found that miR-124 NPs decreased cell death and imp
View details →Athan P Papailiou, David V Yokum, Christopher T Robertson · 2015 · PLoS ONE
In recent decades, social scientists have shown that the reliability of eyewitness identifications is much worse than laypersons tend to believe. Although courts have only recently begun to react to this evidence, the New Jersey judiciary has reformed its jury instructions to notify jurors about the frailties of human memory, the potential for lineup administrators to nudge witnesses towards suspects that they police have already identified, and the advantages of alternative lineup procedures, including blinding of the administrator. This experiment tested the efficacy of New Jersey's jury ins
View details →Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE
Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des
View details →Benedikt J. Wiggli, Reno Frei, Reto Laffer et al. · 2017 · Swiss Medical Weekly
PURPOSE Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MSSA) strains. In the unusual setting of a very low MRSA prevalence institution, we investigated incidence, mortality and trends of BSI caused by MSSA over the last 20 years. OBJECTIVE To evaluate and demonstrate trends in incidence and mortality of MSSA BSI as well as risk factors
View details →Fernando Naclerio, Eneko Larumbe-Zabala, Robert Cooper et al. · 2015 · PLoS ONE
We investigated the effects of ingesting a multi-ingredient (53 g carbohydrate, 14.5 g whey protein, 5 g glutamine, 1.5 g L-carnitine-L-tartrate) supplement, carbohydrate only, or placebo on intermittent performance, perception of fatigue, immunity, and functional and metabolic markers of recovery. Sixteen amateur soccer players ingested their respective treatments before, during and after performing a 90-min intermittent repeated sprint test. Primary outcomes included time for a 90-min intermittent repeated sprint test (IRS) followed by eleven 15 m sprints. Measurements included creatine kina
View details →Hiroyuki Daida, Tomoyuki Takura, Tetsuya Shiina et al. · 2022 · BMJ Open
Objectives Follow-up invasive coronary angiography (FUICA) after percutaneous coronary intervention (PCI) has been shown to increase the rate of early coronary revascularisation without reducing the incidence of subsequent myocardial infarction or death. However, no studies have evaluated the cost-effectiveness of FUICA in patients after coronary stenting. Therefore, this study aimed to evaluate the cost-effectiveness of FUICA after PCI.Design Retrospective observational cohort study.Setting 497 hospitals.Participants and interventions Overall, 558 patients who underwent coronary artery stenti
View details →Scott R Ceresnak, Robert H Pass, Anne M Dubin et al. · 2019 · PLoS ONE
Background In previous pilot work we demonstrated that a novel automated signal analysis tool could accurately identify successful ablation sites during Wolff-Parkinson-White (WPW) ablation at a single center. Objective We sought to validate and refine this signal analysis tool in a larger multi-center cohort of children with WPW. Methods A retrospective review was performed of signal data from children with WPW who underwent ablation at two pediatric arrhythmia centers from 2008-2015. All patients with WPW ≤ 21 years who underwent invasive electrophysiology study and ablation with ablation si
View details →Kaushal Kabir , Keshav Middha , Arora KK et al. · 2023 · Asian Journal of Medical Sciences
Background: Supreme laryngeal mask airway (SLMA) and i-gel airway devices are second generation supraglottic airway devices (SAD) and are good alternatives to intubation during elective surgeries. Aims and Objectives: This study was conducted with the objective of comparing the two SAD with respect to ease of insertion, number of attempts of insertion, insertion time, ease of gastric tube insertion, accompanying hemodynamic changes, incidence of adverse effects like regurgitation, lip and dental trauma, post-operative sore throat, dysphagia, and hoarseness. Materials and Methods: This study wa
View details →S. Iburg, Dandan Izabel-Shen, Å. Austin et al. · 2021 · Msphere
With the increase of recreational boating activity and development of boating infrastructure in shallow, wave-protected areas, there is growing concern for their impact on coastal ecosystems. In order to properly assess the effects and…
View details →M. Helal, A. Said, G. El-DinShams et al. · 2021
This study aimed to determine the effect of cefepime on different liver and kidney functions of healthy rabbits (35days/1kg) were injected with singular intramuscular dose once daily for 5 successive days with 75 mg/kg body weight.…
View details →Dawid Schellingerhout, Lucia G LeRoux, Brian P Hobbs et al. · 2012 · PLoS ONE
Background and purpose The purpose of our study was to utilize a molecular imaging technology based on the retrograde axonal transport mechanism (neurography), to determine if oxaliplatin-induced neurotoxicity affects retrograde axonal transport in an animal model. Materials and methods Mice (n = 8/group) were injected with a cumulative dose of 30 mg/kg oxaliplatin (sufficient to induce neurotoxicity) or dextrose control injections. Intramuscular injections of Tetanus Toxin C-fragment (TTc) labeled with Alexa 790 fluorescent dye were done (15 ug/20 uL) in the left calf muscles, and in vivo flu
View details →Hashem Heshmati, Karim darvishpour · 2015 · مجله ایرانی آموزش در علوم پزشکی
Introduction: Clinical education is one of the most important aspects of medical and paramedical students' education and has a determining role in the professional future of these students as well as other professionals in health care. So this study aimed to evaluate the effective factors in the quality of clinical education from the viewpoints of operation room and Anesthesiology students in Torbat Heydarieh University of Medical Sciences. Methods: In this descriptive cross-sectional study, a number of 115 students of operation room and Anesthesiology studying in Torbat Heydarieh university o
View details →Jan Walleczek, Nikolaus von Stillfried, Stefan Schmidt et al. · 2025 · PLoS ONE
This metascientific project studied the replicability of Bem Experiment 1, which had claimed a precognitive effect, i.e., the ability to successfully guess the outcome of future random events (Bem. J Pers Soc Psychol. 2011;100: 407-25). The use of advanced methodologies-based on the advanced meta-experimental protocol (AMP) and transparent psi project (TPP) procedures-reduced the risk of false discoveries as a function of (i) confirmation bias, (ii) non-transparency, and (iii) intrinsic measurement bias. The combined AMP-TPP test strategy performed three replication studies with a total of 26,
View details →Caitlin N Jacques, Anna K Hulbert, Shelby Westenskow et al. · 2020 · PLoS ONE
BACKGROUND:Recently, it was found that 1% Phytagel plates used to conduct Arabidopsis thaliana seedling phenotypic analysis no longer reproduced previously published results. This Phytagel, which is produced in China (Phytagel C), has replace American-made Phytagel (Phytagel), which is no longer commercially available. In this study, we present the impact of Phytagel produced in the United States vs. China on seedling phenotypic analysis. As a part of this study, an alternative gelling agent has been identified that is capable of reproducing previously published seedling morphometrics. RESULTS
View details →Karen E Mulak, Hannah S Sarvasy, Alba Tuninetti et al. · 2021 · PLoS ONE
Adapting laboratory psycholinguistic methods to fieldwork contexts can be fraught with difficulties. However, successful implementation of such methods in the field enhances our ability to learn the true extent and limitations of human behavior. This paper reports two attempts to run word learning experiments with the small community of Nungon speakers in Towet village in the Saruwaged Mountains, Papua New Guinea. A first attempt involved running a cross-situational task in which word-object pairings were presented ambiguously in each trial, and an explicit word learning task in which pairings
View details →Rukhsana Tumrani, S. Sabahat Haider, Mehvish Sana · 2024 · Pakistan Journal of Medical Research
Background: Serum electrolytes are one of the most frequently requested tests in patients from critical care settings. Methodsfor estimation of serum electrolytes include direct and indirect ion selective electrode (ISE). In case of indirect ISE, the pre-analytical dilution step can result in pseudonormonatremia or pseudohypernatremia in setting of hypoalbuminemia. Discrepancy in sodium results can lead to the misdiagnosis and mismanagement of critically ill patients. Objective: To evaluate the difference of mean serum sodium level measured by direct and indirect ISE in critically ill patients
View details →Teerachate Nantakeeratipat · 2026 · Frontiers in Digital Health
BackgroundLarge Language Models (LLMs) in healthcare holds immense promise yet carries the risk of perpetuating social biases. While artificial intelligence (AI) fairness is a growing concern, a gap exists in understanding how these models perform under conditions of clinical ambiguity, a common feature in real-world practice.MethodsWe conducted a study using an ambiguity-probe methodology with a set of 42 sociodemographic personas and 15 clinical vignettes based on the 2018 classification of periodontal diseases. Ten were clear-cut scenarios with established ground truths, while five were int
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