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Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The Use of Non-Contrast Abbreviated MRI for the Detection of Recurrent Hepatocellular Carcinoma in Postoperative Surveillance.

Chen J, Zhu Y, Zheng D et al. · 2026 · Journal of magnetic resonance imaging : JMRI

Background MRI is sensitive for detecting hepatocellular carcinoma (HCC), but its routine use is hindered by low accessibility. Purpose To evaluate the performance of non-contrast abbreviated MRI (NC-AMRI) alone and in combination with…

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Negative / Null Result ReportMedicine

Achilles tendon rupture does not significantly reduce career longevity in professional soccer players compared with matched controls.

Khan HA, Khan A, Rosenberg A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To compare the career longevity of professional soccer players after achilles tendon rupture (ATR) with that of an uninjured matched control cohort. Methods A retrospective analysis of ATR cases in professional male athletes from…

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Negative / Null Result ReportMedicine

Does a Brochure Reduce Dental Anxiety in Patients Undergoing Third Molar Extraction? A Randomized Clinical Trial.

Schemel-Suarez M, Egido-Moreno S, Martínez-Lizan I et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Dental anxiety frequently compromises patient cooperation and outcomes during third molar (3M) extraction prompting the use of nonpharmacological strategies such as detailed written information. Evidence on reducing preoperative…

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Negative / Null Result ReportMedicine

Effect of additive manufacturing technology and print orientation on the accuracy of static guided implant surgery: An in vitro study.

Amini S, Alshammari M, Abdulhameed N et al. · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

Purpose The aim of this in vitro study was to investigate the effect of print orientation and printing technology on the accuracy of static computer-aided implant surgery (s-CAIS). Materials and methods A cone beam computed tomography…

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Negative / Null Result ReportMedicine

Exploring a Single Music Therapy Session to Reduce 22q11.2 Deletion Syndrome Child and Adolescent's Outpatient Clinic-Related Anxiety.

Broughton MC, Bunzli E, Pagel S et al. · 2026 · Journal of paediatrics and child health

Aim This study explored whether a single music therapy session could reduce 22q11.2 deletion syndrome (DS) children and adolescents' clinic-related anxiety when visiting the hospital outpatient clinic for health appointments. Methods The…

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Negative / Null Result ReportMedicine

Mediating effects of depression, stigma, and self-efficacy on self-management improvement in an evidence-based epilepsy self-management program.

Armah L, Tan L, Branning R et al. · 2026 · Epilepsy & behavior : E&B

Aims To evaluate whether improvements in depressive symptoms, epilepsy self-efficacy, and perceived stigma mediate the association between the SMART intervention and epilepsy self-management. Methods 160 people with epilepsy were enrolled…

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Negative / Null Result ReportMedicine

Relationship Between Mental Health and Protective Health Behaviors in Adolescents: A Secondary Data Analysis.

Mahat G, Zha P · 2026 · Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

Evidence highlights rising mental health concerns among youth. This study investigated the relationship between protective behaviors, including physical activity, regular breakfast, sleep, and parental monitoring, and adolescent mental…

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Negative / Null Result ReportMedicine

Impact of oral glucocorticoids on the effectiveness of romosozumab: the multicenter OASIS cohort study.

Yukishima T, Kobayakawa T, Hirano Y et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

This multicenter retrospective cohort compared romosozumab outcomes between oral glucocorticoid users and non-users. Bone turnover marker responses and lumbar spine bone mineral density gains were similar, whereas total hip bone mineral…

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Negative / Null Result ReportMedicine

Attention Networks and Speech Disfluencies among Monolingual Dutch and Bilingual Dutch-Turkish Speaking Children: A Pilot Study.

Aslan G, Eggers K · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction This pilot study investigated whether attention skills influence speech disfluencies in school-aged children, comparing monolingual Dutch (MONO) speakers and bilingual Dutch-Turkish speakers (BIL). Disfluencies frequently…

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Negative / Null Result ReportMedicine

Influence of the correct placement of external ventricular drainage on puncture channel bleeding in patients with aneurysmal subarachnoid hemorrhage.

Marschal V, Ziebart A, Abdoullahi M et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

While ventriculostomy-associated hemorrhages are well-documented in spontaneous subarachnoid hemorrhage (SAH), the impact of external ventricular drainage (EVD) placement accuracy on puncture channel bleeding (PCB) remains underexplored.…

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Negative / Null Result ReportMedicine

Effects of glucose ingestion on blood flow in the small intestine and exercising limbs during endurance exercise.

Endo MY, Kashima H, Miura A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Performance during endurance exercise depends on the balance between the blood flow (BF) to active muscles and their energy use. We compared the acute cardiovascular regulation after the ingestion of a 300-mL drink containing 50 g glucose…

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Negative / Null Result ReportMedicine

Clinical Characteristics and Management for Flares in Patients With Rheumatoid Arthritis Treated With Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs.

Kim YE, Ahn SM, Oh JS et al. · 2026 · International journal of rheumatic diseases

Objective To evaluate the frequency and management of flares in rheumatoid arthritis (RA) patients treated with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). Methods Data were analyzed from the KOrean…

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Negative / Null Result ReportMedicine

Factors influencing time to speech processor upgrades.

Hung C, Spitzer ER, Waltzman SB · 2026 · Cochlear implants international

Objective Cochlear implant (CI) speech processors have undergone technological advancements. Therefore, patients upgrade speech processors when new features are available or when their previous device becomes broken and is no longer…

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Negative / Null Result ReportMedicine

Non-alcoholic beverage provision reduces alcohol consumption and improves health-related outcomes, with no effect on presenteeism: a randomized controlled trial.

Dobashi S, Hotoge S, Kikuchi A et al. · 2026 · Scientific reports

Excessive alcohol consumption contributes to mortality and productivity losses, yet evidence for workplace-based substitution interventions remains limited. This randomized controlled trial examined whether providing non-alcoholic…

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Negative / Null Result ReportMedicine

Reliability of Noninvasive Blood Pressure Monitoring During Atrial Fibrillation Ablation Under General Anesthesia.

Schwartz J, Al-Sadawi M, Mattimore D et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives To evaluate the accuracy and reliability of noninvasive blood pressure (NIBP) monitoring compared to invasive blood pressure (IBP) measurements during atrial fibrillation (AF) ablation under general anesthesia, and to determine…

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Negative / Null Result ReportMedicine

The effect of eggshell translucency on egg weight, embryonic development, hatching traits, chick quality, post-hatch growth, carcass, and organ traits in Ross 308 fast growing broiler strains at 7 days of age.

Abdallah N, Kursun K, Baylan M · 2026 · Tropical animal health and production

This study investigated the effect of eggshell translucency on egg weight, embryonic development, hatching traits, chick quality, post-hatch growth, carcass, and organ traits at 7 days of age in broiler chickens. A total of 300 hatching…

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Negative / Null Result ReportOpen accessMedicine

[Corrigendum] Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury.

He GQ, Chen Y, Liao HJ et al. · 2026 · Molecular medicine reports

Following the publication of the above article, the authors have contacted the Editor to explain that, regarding the immunofluorescence experiments shown in Fig. 3 on p. 5089, the data correctly shown in Fig. 3I (for the 'V‑ctrl+DMSO+R 24…

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