12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Roy N. Alcalay, Tama Dinur, Timothy J. Quinn et al. · 2014 · JAMA Neurology
IMPORTANCE: Information on age-specific risk for Parkinson disease (PD) in patients with Gaucher disease (GD) and glucocerebrosidase (GBA) heterozygotes is important for understanding the pathophysiology of the genetic association and for…
View details →Patricia A. Ganz, Lorna Kwan, Steven A. Castellon et al. · 2013 · JNCI Journal of the National Cancer Institute
BACKGROUND: Cognitive complaints are reported frequently after breast cancer treatments. Their association with neuropsychological (NP) test performance is not well-established. METHODS: Early-stage, posttreatment breast cancer patients…
View details →Yoshiya Yamada, Evangelia Katsoulakis, Ilya Laufer et al. · 2017 · Neurosurgical FOCUS
OBJECTIVE An analysis of factors contributing to durable radiographic control of spinal metastases was undertaken, drawing from a large single-institution database in an attempt to elucidate indications and dose requirements for successful…
View details →Carlos Celis‐Morales, Donald M. Lyall, Jana Anderson et al. · 2016 · European Heart Journal
Aims: It is unclear whether the potential benefits of physical activity differ according to level of cardiorespiratory fitness (CRF) or strength. The aim of this study was to determine whether the association between physical activity and…
View details →Allen S. Liu, Huang‐Kai Kao, Richard G. Reish et al. · 2011 · Plastic & Reconstructive Surgery
BACKGROUND: Acellular dermal matrix has become a common adjunct in prosthesis-based breast reconstruction. The authors' aim was to determine whether acellular dermal matrix use in immediate prosthesis-based breast reconstruction is…
View details →Yen‐Wei Li, Tung‐Wei Kao, Pi-Kai Chang et al. · 2021 · Scientific Reports
Deeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) has been well established. We conducted a 9-year longitudinal study to identify the association between easily measured lipid parameters, future MetS, hypertension and T2DM by gender and age distribution. Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medi
View details →Gavin Churchyard, Wendy Stevens, L D Mametja et al. · 2015 · The Lancet Global Health
BACKGROUND: In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme…
View details →Carlos Ferrando, Ricard Mellado Artigas, Alfredo Gea et al. · 2020 · Critical Care
BACKGROUND: Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone. METHODS: Prospective, multicenter, adjusted observational cohort study in consecutive COVID-19 patients with acute respiratory failure (ARF) receiving respiratory support with HFNO from 12 March to 9 June 2020. Patients were cla
View details →Jimme K. Wiggers, Bas Groot Koerkamp, Kasia P. Cieslak et al. · 2016 · Journal of the American College of Surgeons
BACKGROUND: Liver surgery for perihilar cholangiocarcinoma (PHC) is associated with postoperative mortality ranging from 5% to 18%. The aim of this study was to develop a preoperative risk score for postoperative mortality after liver…
View details →Chris Twelves, Javier Cortés, Linda T. Vahdat et al. · 2014 · Breast Cancer Research and Treatment
Data from two phase 3 studies of eribulin were pooled in analyses initially requested by the European Medicines Agency to assess whether specific patient subgroups, previously treated with an anthracycline and a taxane, benefited from…
View details →Marieke M. Lansbergen, Martine van Dongen‐Boomsma, Jan K. Buitelaar et al. · 2010 · Journal of Neural Transmission
Electroencephalography (EEG)-neurofeedback has been shown to offer therapeutic benefits to patients with attention-deficit/hyperactivity disorder (ADHD) in several, mostly uncontrolled studies. This pilot study is designed to test the…
View details →Giuseppe Boriani, Antoine Da Costa, Aurelio Quesada et al. · 2016 · European Journal of Heart Failure
AIMS: The aim of this study was to evaluate the clinical efficacy and safety of remote monitoring in patients with heart failure implanted with a biventricular defibrillator (CRT-D) with advanced diagnostics. METHODS AND RESULTS: The…
View details →Daniel J. Owens, Richard J. Allison, Graeme L. Close · 2018 · Sports Medicine
The last decade has seen a dramatic increase in general interest in and research into vitamin D, with many athletes now taking vitamin D supplements as part of their everyday dietary regimen. The most recognized role of vitamin D is its regulation of calcium homeostasis; there is a strong relationship between vitamin D and bone health in non-athletic individuals. In contrast, data have consistently failed to demonstrate any relationship between serum 25[OH]D and bone health, which may in part be due to the osteogenic stimulus of exercise. Vitamin D may interact with extra-skeletal tissues such
View details →Pekka Oja, Paul Kelly, Željko Pedišić et al. · 2016 · British Journal of Sports Medicine
BACKGROUND/AIM: Evidence for the long-term health effects of specific sport disciplines is scarce. Therefore, we examined the associations of six different types of sport/exercise with all-cause and cardiovascular disease (CVD) mortality…
View details →Joshua S. Bingham, Henry D. Clarke, Mark J. Spangehl et al. · 2014 · Clinical Orthopaedics and Related Research
BACKGROUND: Diagnosing a periprosthetic joint infection (PJI) requires a complex approach using various laboratory and clinical criteria. A novel approach to diagnosing these infections uses synovial fluid biomarkers. Alpha defensin-1…
View details →Christoph Garbers, Wolfgang Thaiss, Gareth W. Jones et al. · 2011 · Journal of Biological Chemistry
IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling but was described to not interfere with classic signaling via the membrane-bound IL-6R. Physiological and most pathophysiological conditions are characterized by a molar excess of serum sIL-6R over IL-6 characterized by free IL-6 and IL-6 found in IL-6·sIL-6R complexes allowing both classic and trans-signaling. Surprisingly, under these conditions, sgp130 was able to trap all free IL-6 molecules in IL-6·sIL-6R·sg
View details →US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2018 · JAMA
Importance: Cardiovascular disease (CVD) is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk Score, the Pooled Cohort Equations, or similar CVD risk assessment models. If current CVD risk assessment models could be improved by adding more risk factors, treatment might be better targeted, thereby maximizing the benefits and minimizing the harms. Objective: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on using nontraditional risk factors in coron
View details →Basil T. Darras, Thomas O. Crawford, Richard S. Finkel et al. · 2019 · Annals of Clinical and Translational Neurology
Abstract Objective To evaluate plasma phosphorylated neurofilament heavy chain ( pNF ‐H) as a biomarker in spinal muscular atrophy ( SMA ). Methods Levels of pNF ‐H were measured using the ProteinSimple ® platform in plasma samples from…
View details →James J. McNamee, Michael Gillies, Nicholas Barrett et al. · 2021 · JAMA
Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. Objective: To determine…
View details →Catherine Limperopoulos, Gevorg Chilingaryan, Nancy Sullivan et al. · 2012 · Cerebral Cortex
Cerebellar injury is an important complication of preterm birth with far-reaching neuropsychiatric sequelae. We have previously shown a significant association between isolated injury to the premature cerebellum and subsequent impairment…
View details →Fiona Smaill, Mangalakumari Jeyanathan, Marek Smieja et al. · 2013 · Science Translational Medicine
There is an urgent need to develop new tuberculosis (TB) vaccines to safely and effectively boost Bacille Calmette-Guérin (BCG)-triggered T cell immunity in humans. AdHu5Ag85A is a recombinant human type 5 adenovirus (AdHu5)-based TB…
View details →Sarah Fiddyment, Bruce Holsinger, Chiara Ruzzier et al. · 2015 · Proceedings of the National Academy of Sciences
Tissue-thin parchment made it possible to produce the first pocket Bibles: Thousands were made in the 13th century. The source of this parchment, often called "uterine vellum," has been a long-standing controversy in codicology. Use of the…
View details →Otto Erlwein, Steve Kaye, Myra O. McClure et al. · 2010 · PLoS ONE
BACKGROUND: In October 2009 it was reported that 68 of 101 patients with chronic fatigue syndrome (CFS) in the US were infected with a novel gamma retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), a virus previously linked to prostate cancer. This finding, if confirmed, would have a profound effect on the understanding and treatment of an incapacitating disease affecting millions worldwide. We have investigated CFS sufferers in the UK to determine if they are carriers of XMRV. METHODOLOGY: Patients in our CFS cohort had undergone medical screening to exclude detectable organi
View details →Pedram Gerami, Richard A. Scolyer, Xiaowei Xu et al. · 2013 · The American Journal of Surgical Pathology
Risk assessment for atypical Spitz tumors remains an enigma for physicians. Many prognosticators including sentinel lymph node biopsy fail to show the same prognostic significance in these tumors as seen in conventional melanoma. We…
View details →Henrik Sillesen, Samantha Sartori, Benjamin Sandholt et al. · 2017 · European Heart Journal - Cardiovascular Imaging
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size:…
View details →Yasmine T. Asi, Julie E. Simpson, Paul R. Heath et al. · 2014 · Glia
Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features. α-Synuclein (αsyn), encoded by the gene SNCA, is the main constituent of glial cytoplasmic inclusion (GCI) found in oligodendrocytes in MSA, but the methods of its accumulation have not been established. The aim of this study is to investigate alterations in regional and cellular SNCA mRNA expression in MSA as a possible substrate for GCI formation. Quantitative reverse transcription polymerase chain reaction (qPCR) was performed on postmortem br
View details →Steven M. Opal, R. Phillip Dellinger, Jean‐Louis Vincent et al. · 2014 · Critical Care Medicine
OBJECTIVE: The developmental pipeline for novel therapeutics to treat sepsis has diminished to a trickle compared to previous years of sepsis research. While enormous strides have been made in understanding the basic molecular mechanisms…
View details →US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005,…
View details →Liselotte van Asten, Cees van den Wijngaard, Wilfrid van Pelt et al. · 2012 · The Journal of Infectious Diseases
BACKGROUND: Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance…
View details →Frank W. Roemer, C. Kent Kwoh, Michael J. Hannon et al. · 2015 · Arthritis & Rheumatology
OBJECTIVE: To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. METHODS: We studied 355…
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