12,375 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Hao X, Zhang Z, Cai C et al. · 2026 · International journal of surgery (London, England)
Background Dexmedetomidine was widely used in anesthesia management during cardiac surgery. The purpose was to evaluate the safety and efficacy of intraoperative dexmedetomidine in the treatment of postoperative depression in adult…
View details →Wittberg DM, Admassu F, Aragie S et al. · 2026 · Tropical medicine & international health : TM & IH
Objectives Few randomised trials have been done to assess the impact of hygiene interventions on trachoma even though hygiene improvements feature prominently in the strategy for global elimination of trachoma. This study's aim was to…
View details →Liu C, Deng G, Wang Y et al. · 2026 · Stroke and vascular neurology
Background Transradial access has become an increasingly preferred approach for cerebral angiography. However, embolic events, often clinically silent, remain a frequent concern. Despite routine use, the efficacy and safety of heparin…
View details →Jiang C, Zhao Z, Yang Z et al. · 2026 · Circulation
Background Observational studies have suggested that SGLT2 (sodium-glucose cotransporter 2) inhibitors are associated with a lower risk of atrial fibrillation (AF) recurrence after catheter ablation in patients with AF with concomitant…
View details →Krzyżaniak M, Warmiński K, Olba-Zięty E et al. · 2025 · Industrial Crops & Products
Camelina sativa (L. Crantz) is an annual oilseed crop cultivated for industrial and food purposes. To expand camelina's cultivation area, improve yields, and reduce weed pressure, the crop can be grown in intercropping system. The aim of…
View details →Perez-Valero I, Corona Mata D, Crussells Canales MJ et al. · 2026 · International journal of antimicrobial agents
Objective To evaluate if switching from dolutegravir/lamivudine (DTG/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) improves neuropsychiatric tolerability in suppressed adults with stable neuropsychiatric…
View details →Zhang F, Zhong Y, Li Q et al. · 2025 · High altitude medicine & biology
Zhang, Fengying, Yang Zhong, Qiuyue Li, Doudou Hao, Zhiyou Shi, Suying Zhu, Qian Zhang, and Yunhong Wu. Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.…
View details →Crawford AM, Striano BM, Schoenfeld AJ et al. · 2026 · Spine
Study design Retrospective multicenter cohort study. Objective To compare the safety and efficacy of venous thromboembolism prophylaxis (VTE) strategies between two high-volume spine centers with distinct protocols. Summary of background…
View details →Kinsella A, Gilligan P · 2025 · Irish medical journal
Aim Admission rate is a key performance indicator for Emergency Departments (EDs). Senior hospital management advised that, if discharge by on-call teams was possible within 24 hours, a patient should be termed 'ambulatory' and remain in…
View details →Alves LL, Pinheiro Rosa DC, Freire ML et al. · 2025 · The Journal of antimicrobial chemotherapy
Objective This study aimed at evaluating the combination of a topical hydrophilic gel of paromomycin (PA) with intralesion meglumine antimoniate (Glu IL) or systemic administration of liposomal amphotericin B (AmphLipo) for the treatment…
View details →Warrier T, Martínez-Hoyos M, Porras De Francisco E et al. · 2026 · ACS infectious diseases
A bromoindazole was reported with the ability to rapidly and extensively kill Mycobacterium tuberculosis (Mtb) in vitro, but only in the presence of sublethal levels of reactive nitrogen species (RNS) (Warrier et al., ACS Infectious…
View details →Sher DJ, Avkshtol V, Lin MH et al. · 2025 · Journal of the National Cancer Institute
Background The utility of adaptive radiotherapy (ART) for head and neck squamous cell carcinoma (HNSCC) remains poorly defined. Daily ART (DART) promises both anatomic adaptation and planning target volume (PTV) reduction. In this…
View details →Furman CR, Worth IA, Zhang JD et al. · 2025 · Behavioral medicine (Washington, D.C.)
Eating and exercise habits established in adolescence are associated with immediate and long-term health outcomes. These habits may be influenced by adolescents' socioeconomic status (SES), such that low SES households often experience…
View details →Hay AD, Abbs S, Ridd M et al. · 2026 · JAMA internal medicine
Importance Most antibiotic prescribing takes place in primary care, driving antimicrobial resistance, a top-10 threat to global public health. There is considerable international interest in whether rapid multiplex microbiological…
View details →Zhang IY, Flum DR, Khandelwal S et al. · 2025 · Annals of surgery
Objective We aimed to evaluate the impact of an electronic health record (EHR)-based default "nudge" intervention on opioid prescribing after common surgical operations. Background Given ongoing national challenges in opioid use and…
View details →Xu J, Chen Y, Gong C et al. · 2025 · Journal of infection in developing countries
Introduction Tuberculous empyema, a severe complication of pulmonary tuberculosis, often requires surgical intervention in stage III to remove fibrotic tissue and restore lung function. Methodology This retrospective study enrolled 224…
View details →Baltruskeviciute L, Moccetti F, Wolfrum M et al. · 2026 · The American journal of cardiology
Cerebrovascular accidents (CVA) after transcatheter aortic valve implantation (TAVI) remain a major concern. However, the impact of aortic arch morphology has not been investigated in this context. To address this gap, consecutive patients…
View details →Madden KM, Feldman B, Meneilly GS · 2025 · Canadian journal on aging = La revue canadienne du vieillissement
Postprandial hypotension (PPH) is defined as a postprandial decline in systolic blood pressure (SBP) of 20 mm of Hg. Some have recommended the use of acarbose (an alpha-glucosidase inhibitor) as a potential therapy for PPH based…
View details →Martínez-Lentisco MDM, Carreño-Segura S, León-Morillas F et al. · 2026 · Clinical pediatrics
This quasi-experimental study assessed the impact of a postpartum educational programme on health care utilization and maternal stress in mothers of infants with colic. A total of 84 mothers took part in 2 individual sessions, 15 days…
View details →Gaillard C, Breul L, Foucher A et al. · 2026 · British journal of anaesthesia
Background The EPITUBE trial aimed to determine whether a prophylactic infusion of norepinephrine reduced severe hypotension after induction of general anaesthesia and tracheal intubation in patients undergoing cardiac surgery. Methods We…
View details →Refardt J, Potasso L, Pelouto A et al. · 2026 · NEJM evidence
Background Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply an indicator of underlying…
View details →Dodson JA, Adhikari S, Schoenthaler AM et al. · 2026 · Journal of the American College of Cardiology
Background Nonadherence to antihypertensive medications is common. Mobile health (mHealth)-based behavioral economic interventions may improve adherence, but remain largely untested, especially in vulnerable populations. Objective The…
View details →Azevêdo LM, da Silva Junior ND, de Oliveira GF et al. · 2025 · GeroScience
Previous data showed greater blood pressure (BP) reduction after aerobic training performed in the evening than in the morning in middle-aged hypertensive men. This study investigated whether the time of day in which aerobic training is…
View details →Amour J, Naudin C, Besnard A et al. · 2026 · British journal of anaesthesia
Background Postoperative atrial fibrillation (POAF) affects 30% of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Beta-blockers are the first-line agents recommended for POAF prevention. Landiolol, an…
View details →Lin W, Zhang X, Zhuo Y et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Chronic postsurgical pain (CPSP) affects up to 60% of breast cancer surgery patients, substantially impairing quality of life. Although erector spinae plane block (ESPB) provides effective acute analgesia with superior safety…
View details →Dubreucq Guerif E, Agut S, Rousseau A et al. · 2026 · European journal of emergency medicine : official journal of the European Society for Emergency Medicine
Background and importance Vaso-occlusive crisis is the main reason for emergency department (ED) visits for patients with sickle cell disease. Therapeutic management involves multimodal analgesia, which often comprises the administration…
View details →Hofherr A, Mäki-Petäjä K, Selvarajah V et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points In 558 adults with type 2 diabetes and CKD, inhibition of IL-33 by tozorakimab was well tolerated. IL-33 signaling was blocked at all doses, eosinophil counts decreased, and urinary CC-chemokine ligand 2 decreased at the high…
View details →Alkaramany E, Gallagher BP, Abbasi P et al. · 2025 · Foot & ankle international
Background Previous investigations have speculated that stiffening the lateral column of the hindfoot in triple arthrodesis can increase lateral plantar pressure with resulting lateral column pain. It is unclear whether sparing of the…
View details →Wang Y, Wang S, Lin J et al. · 2026 · Journal of affective disorders
Objective The current study aimed to explore the effectiveness and mechanisms of mindfulness on alleviating both immediate and delayed negative interpretation biases (NIB). Method A total of 105 college students (female: 84.62 %, age:…
View details →Marckmann M, Henriksen NA, Krarup PM et al. · 2025 · The British journal of surgery
Background The benefit of closed incision negative-pressure therapy (ciNPT) after open incisional hernia repair in reducing surgical-site infection (SSI) is uncertain. Methods The PROPRESS multicentre RCT was conducted from 1 March 2023 to…
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