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WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Combined effects of mesenchymal stromal cells and antibiotic therapy on Enterobacter ventilator-associated pneumonia in rabbits.

Jacquier M, Laroye C, Bensoussan D et al. · 2026 · Respiratory research

Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a…

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Negative / Null Result ReportMedicine

Systemic Administration of an Anti-CD18 Antibody Prevents the Accumulation of Peripheral Leukocytes in Pericontusional Tissue, but Does Not Improve Outcome after Traumatic Brain Injury in Mice.

Guo Y, Hu S, Wang Z et al. · 2026 · Journal of neurotrauma

The formation of brain edema is one of the key factors that determine patient outcomes following traumatic brain injury (TBI). Despite decades of research, no causal treatment is available to date. Among the many factors discussed,…

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Negative / Null Result ReportMedicine

Early recurrence after primary TURBT for non-muscle-invasive bladder cancer in Iceland: the critical role of surgical quality.

Björnsson O, Geirsson G, Leifsson ÁS et al. · 2026 · Scandinavian journal of urology

Introduction Transurethral resection of bladder tumor (TURBT) is the standard treatment for non-muscle-invasive bladder cancer (NMIBC), but early recurrences remain frequent. The objective of this study was to standardize TURBT management…

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Negative / Null Result ReportMedicine

Testosterone replacement therapy in older men: skeletal outcomes and fracture risk.

Szarpak L, Al-Jeabory M, Pecold J et al. · 2026 · The aging male : the official journal of the International Society for the Study of the Aging Male

Introduction Testosterone replacement therapy (TRT) is increasingly prescribed to older men with symptomatic testosterone deficiency, yet the balance of musculoskeletal benefits and harms remains uncertain. Objectives To synthesise current…

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Negative / Null Result ReportMedicine

Densiron 68 Tamponade Duration and Redetachment Risk after Removal in Inferior Proliferative Vitreoretinopathy-Associated Retinal Detachment.

Carnevali A, Chisari D, Mancini A et al. · 2026 · Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

Introduction Inferior retinal detachment (I-RD) complicated by proliferative vitreoretinopathy (PVR) is challenging to treat and prone to recurrence (retinal detachment recurrence [RDR]). Heavy silicone oil (HSO) tamponades such as…

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Negative / Null Result ReportMedicine

Original research: surfactant administration using less invasive surfactant administration (LISA) versus enhanced intubate-surfactant-extubate (ENSURE) in preterm infants.

Khera P, Jain S, Khurana S et al. · 2026 · European journal of pediatrics

Surfactant replacement therapy improves outcomes in preterm neonates with respiratory distress syndrome (RDS). While the less invasive surfactant administration (LISA) technique offers advantages over intubate-surfactant-extubate (INSURE),…

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Replication FailureMedicine

Prospective observational comparative study on antibiotic prophylaxis in cystoscopy: towards a rational use of antimicrobials.

Magno Serrano P, Barros P, Dores M et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

Introduction Antibiotic resistance represents a major public health problem driven by inappropriate antimicrobial use. Cystoscopy is a common urological procedure associated with a low risk of urinary tract infection (UTI), and the role of…

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Negative / Null Result ReportMedicine

Low-fat dietary pattern and dementia mortality: a secondary analysis of the Women's Health Initiative dietary modification randomized clinical trial with long-term follow-up.

Chlebowski RT, Rapp S, Aragaki AK et al. · 2026 · Menopause (New York, N.Y.)

Objectives In the Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, the dietary intervention significantly reduced breast cancer mortality and, in a subgroup of women 65 years old or above, significantly lowered…

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Negative / Null Result ReportMedicine

Anterior quadratus lumborum block in total hip arthroplasty: a two-center, randomized, placebo-controlled trial showing no additional benefit over multimodal analgesia.

Rozier R, Loiseleur A, Ciais C et al. · 2026 · Regional anesthesia and pain medicine

Background Total hip arthroplasty (THA) frequently causes postoperative pain, hindering recovery and prolonging hospital stays. While multimodal analgesia aims to minimize opioid use and enhance outcomes, the optimal regional anesthesia…

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Negative / Null Result ReportMedicine

Levan-derived oligosaccharides (LOS) confer selective resistance against Phytophthora capsici but not Botrytis cinerea in melon and watermelon.

Yang M, Chen Y, Yang L et al. · 2026 · International journal of biological macromolecules

Plants face significant threats from pathogens while chemical pesticides remain the primary method for disease control. However, excessive use of chemical pesticides has led to increased pathogen resistance and environmental hazards,…

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Negative / Null Result ReportMedicine

The defense-inducing compound N-hydroxy pipecolic acid is a major substrate for the methyltransferase PbBSMT of Plasmodiophora brassicae.

Benade F, Jülke S, Schwelm A et al. · 2026 · Journal of experimental botany

The clubroot pathogen Plasmodiophora brassicae has an effector protein that can methylate the plant defense compound salicylic acid (SA), and the protein sequence is highly conserved in different isolates worldwide. Sequencing the…

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Negative / Null Result ReportMedicine

Early risk assessment and aspirin prophylaxis did not reduce preterm preeclampsia in Sweden: a population-based study.

Mans-Gallart N, Carlhäll S, Hildebrand E et al. · 2026 · American journal of obstetrics and gynecology

Background Preeclampsia is a substantial cause of maternal and perinatal morbimortality, with complications becoming more severe the earlier it manifests during pregnancy. The Fetal Medicine Foundation has developed a method that combines…

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Negative / Null Result ReportMedicine

Randomized field trial on the effects of on-arrival intranasal vaccination against bovine coronavirus on pneumonia and average daily gain in beef-on-dairy calves.

Jourquin S, Lowie T, Clinquart J et al. · 2026 · Journal of dairy science

This randomized clinical trial evaluated the effect of upon-arrival intranasal vaccination against bovine coronavirus (BCoV) on pneumonia risk in a beef-on-dairy veal production system. Secondary objectives were to assess the effect…

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Negative / Null Result ReportMedicine

Targeted Antimicrobial Agent Prophylaxis Fails to Reduce Peristomal Infections by Multi-Drug-Resistant Bacteria Following Percutaneous Endoscopic Gastrostomy: A Prospective Cohort Study.

Marzo-Escartín B, Villamarín-Melio M, Márquez-Algaba E et al. · 2026 · Surgical infections

Background Peristomal infection (PI) is the most frequent complication following percutaneous gastrostomy, and the increase of multi-drug-resistant (MDR) bacteria poses a therapeutic challenge. We evaluated whether targeted antimicrobial…

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Negative / Null Result ReportMedicine

A Single-Centre, Single-Blinded Randomized Control Trial Evaluating the Role of Distraction Therapy in Pain Management Following Major Abdominal Surgeries in Adult Cancer Patients.

Rana CJ, Bakshi SG, Tarhane S et al. · 2026 · Indian journal of surgical oncology

Distract trial In the post-operative period, analgesics are complemented with non-pharmacological methods (NPM). However, the evidence is limited. Objectives Randomised control trial aimed to determine the effectiveness of NPMs of pain…

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Negative / Null Result ReportMedicine

Lanthanum carbonate does not reduce urinary oxalate excretion in hyperoxaluric kidney stone formers.

Van de Perre E, Tielemans C, De Clerck D et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis Hyperoxaluria is an important risk factor for kidney stone formation. Currently available treatment options for idiopathic hyperoxaluria have limited efficacy and are difficult to maintain in the long-term.…

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Negative / Null Result ReportMedicine

Efficacy of Surgeon-Administered Regional Anesthesia in Cardiac Surgery: A Double-Blinded, 2-Center, Randomized, Placebo-Controlled Trial.

Rasmussen JJ, Bisgaard J, Hønge JL et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives Managing pain after median sternotomy is a clinical challenge of balancing adequate pain relief with avoidance of excessive opioid consumption. While regional anesthesia techniques are increasingly recommended and applied in…

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Negative / Null Result ReportMedicine

Closed incisional negative-pressure wound therapy vs standard surgical dressing for groin incisions following arterial vascular surgery: A prospective multicenter randomized clinical trial.

Lenselink E, Ruig M, Grootendorst DC et al. · 2026 · Journal of vascular surgery

Objective Groin wound complications-including surgical site infections, hematomas, seroma leakage, necrosis, and wound dehiscence-are frequently reported after arterial vascular surgery and significantly impact patient morbidity and…

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