12,241 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zhang IY, Flum DR, Khandelwal S et al. · 2025 · Annals of surgery
Objective We aimed to evaluate the impact of an electronic health record (EHR)-based default "nudge" intervention on opioid prescribing after common surgical operations. Background Given ongoing national challenges in opioid use and…
View details →Xu J, Chen Y, Gong C et al. · 2025 · Journal of infection in developing countries
Introduction Tuberculous empyema, a severe complication of pulmonary tuberculosis, often requires surgical intervention in stage III to remove fibrotic tissue and restore lung function. Methodology This retrospective study enrolled 224…
View details →Baltruskeviciute L, Moccetti F, Wolfrum M et al. · 2026 · The American journal of cardiology
Cerebrovascular accidents (CVA) after transcatheter aortic valve implantation (TAVI) remain a major concern. However, the impact of aortic arch morphology has not been investigated in this context. To address this gap, consecutive patients…
View details →Madden KM, Feldman B, Meneilly GS · 2025 · Canadian journal on aging = La revue canadienne du vieillissement
Postprandial hypotension (PPH) is defined as a postprandial decline in systolic blood pressure (SBP) of 20 mm of Hg. Some have recommended the use of acarbose (an alpha-glucosidase inhibitor) as a potential therapy for PPH based…
View details →Martínez-Lentisco MDM, Carreño-Segura S, León-Morillas F et al. · 2026 · Clinical pediatrics
This quasi-experimental study assessed the impact of a postpartum educational programme on health care utilization and maternal stress in mothers of infants with colic. A total of 84 mothers took part in 2 individual sessions, 15 days…
View details →Gaillard C, Breul L, Foucher A et al. · 2026 · British journal of anaesthesia
Background The EPITUBE trial aimed to determine whether a prophylactic infusion of norepinephrine reduced severe hypotension after induction of general anaesthesia and tracheal intubation in patients undergoing cardiac surgery. Methods We…
View details →Refardt J, Potasso L, Pelouto A et al. · 2026 · NEJM evidence
Background Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply an indicator of underlying…
View details →Dodson JA, Adhikari S, Schoenthaler AM et al. · 2026 · Journal of the American College of Cardiology
Background Nonadherence to antihypertensive medications is common. Mobile health (mHealth)-based behavioral economic interventions may improve adherence, but remain largely untested, especially in vulnerable populations. Objective The…
View details →Azevêdo LM, da Silva Junior ND, de Oliveira GF et al. · 2025 · GeroScience
Previous data showed greater blood pressure (BP) reduction after aerobic training performed in the evening than in the morning in middle-aged hypertensive men. This study investigated whether the time of day in which aerobic training is…
View details →Amour J, Naudin C, Besnard A et al. · 2026 · British journal of anaesthesia
Background Postoperative atrial fibrillation (POAF) affects 30% of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Beta-blockers are the first-line agents recommended for POAF prevention. Landiolol, an…
View details →Lin W, Zhang X, Zhuo Y et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Chronic postsurgical pain (CPSP) affects up to 60% of breast cancer surgery patients, substantially impairing quality of life. Although erector spinae plane block (ESPB) provides effective acute analgesia with superior safety…
View details →Dubreucq Guerif E, Agut S, Rousseau A et al. · 2026 · European journal of emergency medicine : official journal of the European Society for Emergency Medicine
Background and importance Vaso-occlusive crisis is the main reason for emergency department (ED) visits for patients with sickle cell disease. Therapeutic management involves multimodal analgesia, which often comprises the administration…
View details →Hofherr A, Mäki-Petäjä K, Selvarajah V et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points In 558 adults with type 2 diabetes and CKD, inhibition of IL-33 by tozorakimab was well tolerated. IL-33 signaling was blocked at all doses, eosinophil counts decreased, and urinary CC-chemokine ligand 2 decreased at the high…
View details →Alkaramany E, Gallagher BP, Abbasi P et al. · 2025 · Foot & ankle international
Background Previous investigations have speculated that stiffening the lateral column of the hindfoot in triple arthrodesis can increase lateral plantar pressure with resulting lateral column pain. It is unclear whether sparing of the…
View details →Wang Y, Wang S, Lin J et al. · 2026 · Journal of affective disorders
Objective The current study aimed to explore the effectiveness and mechanisms of mindfulness on alleviating both immediate and delayed negative interpretation biases (NIB). Method A total of 105 college students (female: 84.62 %, age:…
View details →Marckmann M, Henriksen NA, Krarup PM et al. · 2025 · The British journal of surgery
Background The benefit of closed incision negative-pressure therapy (ciNPT) after open incisional hernia repair in reducing surgical-site infection (SSI) is uncertain. Methods The PROPRESS multicentre RCT was conducted from 1 March 2023 to…
View details →Bannink A, Kamstra-Brouwer H, van Wesemael D et al. · 2026 · Journal of dairy science
A feeding trial was conducted with 60 mid-lactation cows that were, on average, 116 DIM, parity 3.5, and with a fat- and protein-corrected milk (FPCM) yield of 34 kg/d. Cows were blocked based on cow traits and milk performance. Cows in…
View details →Hiroki S, Fukasawa T, Yokogawa K et al. · 2025 · Journal of medical virology
Patients with type 2 diabetes have a higher risk of herpes zoster (HZ). Although metformin may reduce this risk via immunomodulatory effects, prior evidence is limited by confounding by indication and an unclear causal estimand. We aimed…
View details →Gulersen M, Berghella V, Bornstein E · 2025 · Journal of clinical medicine
Singleton pregnancies complicated by a short cervical length (≤25 mm) are at significantly increased risk for spontaneous preterm birth. Several treatment strategies aimed at reducing this risk and improving perinatal outcomes have been…
View details →Boff GA, Iepsen LB, Serighelli-Junior G et al. · 2025 · Veterinary research communications
This study aimed to evaluate the effects of magnesium sulfate on propofol requirements and perioperative analgesia in dogs undergoing ovariohysterectomy. Fourteen female dogs (2 ± 1 years, 17 ± 5 kg) were enrolled in this randomized and…
View details →LeBoff MS, Chou SH, Ratnarajah DM et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Although preclinical studies suggest that omega-3 fatty acids may benefit skeletal health, there are few randomized controlled trials investigating effects of supplemental omega-3 on bone outcomes. This VITamin D and OmegA-3 TriaL (VITAL)…
View details →Kimura K, Minagawa R, Iseda N et al. · 2025 · Anticancer research
Background/aim Pseudoaneurysm hemorrhage after pancreatectomy can be fatal. However, effective intraoperative preventive strategies remain unclear. This study evaluated the efficacy of fibrin glue combined with polyglycolic acid (PGA)…
View details →Kapur NK, Mangner N, Aghili N et al. · 2026 · Journal of the American College of Cardiology
Background Despite rapid percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), large infarcts contribute to heart failure and mortality. Left ventricular (LV) wall tension and load are major…
View details →Patel PY, Akhani MK, Rathod R et al. · 2025 · Cureus
Introduction and aim Laparoscopic cholecystectomy (LC) is the gold standard for gallstone disease, but conversion to open surgery may be required in difficult cases. The role of drain placement after cholecystectomy remains controversial.…
View details →Tasci A, Tasci EDK, Turan CA et al. · 2026 · Journal of applied toxicology : JAT
Intravenous lipid emulsion (ILE) is an established antidote for local anesthetic systemic toxicity and has been tested in various lipophilic drug intoxications, but its efficacy in pioglitazone toxicity remains unclear. This study…
View details →Hovgaard HL, Vistisen ST, Enevoldsen J et al. · 2026 · Anesthesiology
Background Esophagectomy is a key treatment for esophageal cancer but carries a high risk of postoperative complications, some of which are potentially preventable through optimized hemodynamic management. Goal-directed fluid therapy…
View details →Yan CL, Erben A, Sarmiento K et al. · 2025 · Quality management in health care
Background Heart failure (HF) readmission rates at our institution were often higher than the expected levels for our institution type. Social work post-discharge telephone calls were identified as an opportunity to address reasons for HF…
View details →Vafaei A, Manavi MA, Toutounchian S et al. · 2025 · Neurochemical research
Status epilepticus (SE) is a severe neurological condition with high morbidity and mortality rates. Despite the availability of treatments, many cases remain refractory to standard therapies. In this study we investigated the possible…
View details →Shoubridge AP, Brass A, Crotty M et al. · 2025 · JAMA internal medicine
Importance Infectious outbreaks of respiratory viruses within long-term care facilities (LTCFs) for older adults are associated with high rates of hospitalization and death. Despite evidence that airborne transmission contributes…
View details →Qiao W, Liu L, Zhang X et al. · 2025 · BMC anesthesiology
Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high block…
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