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WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Comparing a Conceptual Framework and Factor Analysis to Achieve Survey Item Reduction in Predicting Medication Non-Persistence.

Umeaghadi CF, Taylor JG, Yao S et al. · 2026 · Patient preference and adherence

Adherence surveys can be lengthy due to the high number of potential risk factors to be analyzed. As a result, researchers often reduce items into conceptual domains (eg, beliefs, economic factors) to overcome power constraints or focus…

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Negative / Null Result ReportMedicine

Acceptability of Adolescent Portal Access Policies to Parents and Adolescents: A Delphi Study.

Sisk BA, Antes AL, Bereitschaft C et al. · 2025 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Purpose United States healthcare systems have enacted varied adolescent online patient portal policies. No prior work has established whether these policies are acceptable to adolescents and parents. Methods Mixed-method Delphi approach…

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Negative / Null Result ReportOpen accessMedicine

Safety Audit of a Large Language Model for Lay Self-Triage Using Japanese Symptom Vignettes: Persistent Red-Flag Under-Triage Despite Improved Reproducibility Under Near-Deterministic Decoding.

Harada Y · 2026 · Cureus

Introduction Large language models are increasingly discussed as tools for patient-facing symptom assessment, but safe self-triage depends on the concrete next action recommended to the user rather than on generic urgency language alone.…

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Negative / Null Result ReportMedicine

The State of Surgery in Botswana, 2018 to 2022.

Romeo DJ, Wagner CS, Ahluwalia V et al. · 2025 · The Journal of craniofacial surgery

Many people living in low-income and middle-income countries (LMICs) lack access to safe surgical and anesthetic care. The Lancet Commission on Global Surgery (LCGS) recommended that all countries track surgical volume and target 5,000…

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Negative / Null Result ReportMedicine

Factors associated with failure to achieve Scoliosis Research Society-22r minimal clinically important difference despite achieving optimal global alignment in adult spinal deformity surgery.

Park SJ, Park JS, Kang DH et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To identify factors associated with failure to achieve the minimal clinically important difference (MCID) in the Scoliosis Research Society-22r (SRS-22r) despite achieving optimal global alignment in adult spinal deformity (ASD)…

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Negative / Null Result ReportOpen accessMedicine

Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery.

Drew RH, Turner NA, Keil E et al. · 2026 · Infection control and hospital epidemiology

In a propensity-matched cohort of adult cardiac or neurosurgical procedures ( n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically…

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Negative / Null Result ReportMedicine

Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry.

Schmitt A, Behnes M, Bertsch T et al. · 2025 · European journal of internal medicine

Background Elevated uric acid (UA) is a recognized biomarker in patients with cardiovascular disease. However, the prognostic significance of UA levels in patients with heart failure (HF), particularly those with HF with mildly reduced…

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Negative / Null Result ReportMedicine

Vaccine hesitancy among nurses in the Marche Region.

Fortunato C, Gasperini B, Mengarelli Rinaldini D et al. · 2025 · Annali di igiene : medicina preventiva e di comunita

Background Vaccine hesitancy is considered one of the top ten threats to global health by the World Health Organization due to the potential public health consequences. Since April 1, 2021, the Italian Government has made COVID-19…

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Negative / Null Result ReportOpen accessMedicine

A randomised, double-blind, placebo-controlled trial to assess the postprandial dose-dependent effects of wild blueberries on metabolic and cognitive outcomes following a high-carbohydrate breakfast.

Ellis LR, O'Connor D, Khan H et al. · 2026 · European journal of nutrition

Purpose Despite equivocal human study data, anthocyanin-rich blueberries are associated with positive glycaemic effects which could benefit satiety and other cardiometabolic outcomes. The objective of this study was to examine the…

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Negative / Null Result ReportMedicine

Discovery of HCV vaccine: Where do we stand?

Balakrishnan P, Saravanan S, Vignesh R et al. · 2025 · Indian journal of medical microbiology

Background Hepatitis C virus (HCV) is still a serious public health issue because it can cause cirrhosis, hepatocellular carcinoma (HCC), and chronic hepatitis. In almost 70 % of cases, HCV infection results in chronic persistence, which…

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Negative / Null Result ReportOpen accessMedicine

Application of Autologous Platelet-Rich Plasma-Supplemented Medium Promotes <i>In Vitro</i> Maturation of Human Germinal Vesicle Oocytes.

Rezaie MJ, Allahveisie A, Nikkhoo B et al. · 2025 · International journal of fertility & sterility

Background Oocyte in vitro maturation (IVM) is a valuable technology applied to acquire fully developed oocytes for several clinical purposes. Despite substantial research on optimizing culture media, the success rate of IVM remains low.…

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Negative / Null Result ReportOpen accessMedicine

Register-based observational study of associations between inflammatory remission, formal treatment targets and the use of disease-modifying antirheumatic drugs among patients with early rheumatoid arthritis.

Lindqvist J, Askling J, Lampa J · 2023 · RMD open

Objective To assess associations between inflammatory remission, formal treatment targets and the likelihood of starting a new disease-modifying antirheumatic drug (DMARD), among patients with early rheumatoid arthritis (RA). Methods…

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Negative / Null Result ReportMedicine

Operative Management of Perianal Crohn's Disease.

Wilkinson T, Booth K · 2025 · The Surgical clinics of North America

The management of perianal Crohn's disease is challenging and complex and requires a multidisciplinary approach as a favorable working relationship between gastroenterologists and colorectal surgeons is necessary to provide excellent care…

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Negative / Null Result ReportOpen accessMedicine

Evaluating oral ketamine's adverse side effects in chronic pain patients.

Hom B, McIntee D, Zhang YP et al. · 2025 · Saudi journal of anaesthesia

Background Ketamine has been shown to be an effective treatment at sub-anesthetic doses for various chronic pain conditions. This study assesses the relationship between oral ketamine and the incidence of adverse side effects in patients…

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Negative / Null Result ReportMedicine

Standardization of Lesion Classification and Assessment by Investigators in Clinical Trials for Hidradenitis Suppurativa: A Consensus Exercise Using a Modified Delphi Approach.

Garg A, Strunk A, Midgette B et al. · 2026 · JAMA dermatology

Importance Accurate classification and reliability in assessment for lesions of hidradenitis suppurativa (HS) by investigators is critical to the determination of responder status and to overall data quality in clinical trials. Objective…

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Negative / Null Result ReportOpen accessMedicine

The use of cellphone based automated pupillometry to quantify opioid withdrawal in patients receiving treatment for opioid use disorder.

Evonko CJ, Vigilante KC, Leli NB et al. · 2026 · Journal of substance use and addiction treatment

Introduction Overdose deaths attributed to opioid misuse resulted in over 50,000 deaths in 2024. Opioid agonist therapies such as methadone and buprenorphine are effective for the treatment of opioid use disorder (OUD). Yet, patient…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of dilution ventilation in mitigating occupational exposure to volatile organic compounds (VOCs) at the breathing zone of nail technicians: a simulation study.

Salari S, Fazeli-Tabar S, Karimi A et al. · 2026 · Scientific reports

Volatile Organic Compounds (VOCs) from nail products pose potential health risks to technicians and clients. The present study investigates the exposure of nail technicians to VOC and assesses the effectiveness of dilution ventilation in…

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Negative / Null Result ReportOpen accessMedicine

Motives of Children for Digital Gaming and Physical Activity and Their Parents' Perceptions: Cross-Sectional Matched-Pair Study.

Wachholz F, Gamper N, Kruse S et al. · 2026 · JMIR pediatrics and parenting

Background Physical activity (PA) is essential for the healthy development of children. However, the pervasive presence of digital technologies has made digital gaming (DG) a prominent part of children's everyday lives. As children grow up…

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Failed Experiment ReportMedicine

Effect of cross-head speed on the bond strength of dental resin to tooth structure - A review and re-analysis.

Hassan Elnadif H, Darvell BW · 2024 · Dental materials : official publication of the Academy of Dental Materials

Objective To review the published evidence for the role of cross-head speed on the apparent mechanical properties and bond strength of filled resins to tooth structure in order to identify the causes of inconsistency and contradictory…

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Negative / Null Result ReportOpen accessMedicine

Extent of Pelvic Lymph Node Dissection at Partial Cystectomy: Effect on Cancer-Specific Mortality.

Longoni M, Marmiroli A, Falkenbach F et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Introduction We assessed the extent of pelvic lymph node dissection (PLND) at partial cystectomy (PC) according to PC eligibility (≤cT2 stage, tumor ≤ 3 cm and segmental resection possible) and tested its effect on cancer-specific…

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