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Browse the failure-mode index

12,241 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Trajectory of COVID-related tinnitus over the pandemic timeline.

Figueiredo RR, de Azevedo AA, Figueiredo GMR et al. · 2026 · Brazilian journal of otorhinolaryngology

Objectives COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. Previous studies reported cases of tinnitus following COVID infection, most of them mild and with similar characteristics to other forms of tinnitus. Our…

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Negative / Null Result ReportOpen accessMedicine

Can supplementation of tryptophan in parenteral nutrition increase melatonin and alleviate inflammatory response?

Yaşar NF, Badak B, Salış M et al. · 2024 · Revista da Associacao Medica Brasileira (1992)

Objective Endogenous melatonin is produced from tryptophan which is an essential amino acid. Besides its role in the regulation of sleep patterns, melatonin has anti-inflammatory effects. In this case-control study, we aimed to compare…

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Negative / Null Result ReportOpen accessMedicine

Manual and automated assessments of general movements in neonates are associated with early autism risk at 18 months.

Beaulieu A, Saint-Georges C, Hagbarth I et al. · 2026 · Scientific reports

General movements (GMs) refer to infants’ spontaneous motor activities before the emergence of voluntary motor activity. Abnormal GMs in neonates have been regarded as a marker of poor neurodevelopmental outcomes, with preliminary findings…

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Negative / Null Result ReportOpen accessMedicine

Discontinuing the recommendation of hip precautions does not increase the risk of early dislocation after primary total hip arthroplasty using 36-mm heads: a population-based study from the Danish Hip Arthroplasty Register.

Iljazi A, Sørensen MS, Winther-Jensen M et al. · 2024 · Acta orthopaedica

Background and purpose Dislocation is a severe complication following total hip arthroplasty (THA). Hip precautions have been recommended in the initial postoperative period but evidence supporting this practice is limited. We therefore…

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Negative / Null Result ReportMedicine

Frequent Sugar-Sweetened Beverage Consumption, Dental Caries, and the Federal Poverty Level in Children 1-18 Years, NHANES 2015-2020.

Wiener RC, Abuhalimeh B, Cochran J · 2025 · Community dentistry and oral epidemiology

Objective The objective of this research was to determine if the ratio of family income to poverty index is a modifier in the relationship of sugar-sweetened beverages (SSB) and dental caries in U.S. children. Methods A cross-sectional…

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Negative / Null Result ReportOpen accessMedicine

Replicability or revision? Further evidence on the psychometric quality of the German version of the epistemic trust, mistrust and credulity questionnaire.

Schwarzer NH, Behringer N, Dees P et al. · 2026 · BMC psychology

Background The Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) assesses individual differences in epistemic stances. Although widely used, its German translation has not yet undergone an independent psychometric evaluation.…

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Negative / Null Result ReportMedicine

'July effect' in management and outcomes of patients admitted with pulmonary embolism in the United States, 2016 to 2021.

Bansal M, Mehta A, Morris DL et al. · 2025 · Proceedings (Baylor University. Medical Center)

Background This study sought to assess the outcomes of pulmonary embolism (PE) admissions at teaching and nonteaching hospitals in the month of July, when new trainees begin their training in the United States. Methods During 2016-2021,…

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Negative / Null Result ReportMedicine

Assessing the in vivo impact of novel β-lactamase inhibitors on the efficacy of their partner β-lactams against serine carbapenemase-producing Pseudomonas aeruginosa using human-simulated exposures.

Ruiz VH, Gill CM, Nicolau DP · 2024 · The Journal of antimicrobial chemotherapy

Objectives To evaluate the efficacy of human-simulated regimens (HSRs) of ceftazidime, ceftazidime/avibactam, imipenem, imipenem/relebactam, meropenem and meropenem/vaborbactam in a murine thigh infection model against serine…

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Negative / Null Result ReportOpen accessMedicine

Longitudinal Changes in Sensory Processing and Clinical Outcomes During Spinal Cord and Dorsal Root Ganglion Stimulation to Treat Chronic Pain: A Pilot Study.

Rogers ER, Sankarasubramanian V, Kyi WHT et al. · 2025 · Journal of pain research

Purpose The analgesic mechanisms and neurophysiological effects of spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS) are poorly understood. In this pilot repeated-measures study, we used quantitative sensory testing…

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Negative / Null Result ReportMedicine

High Prevalence and Clinical Relevance of Intrapulmonary Vascular Dilatations in Patients Undergoing TIPS Implantation.

Mauz JB, Rieland H, Berliner D et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Considerate patient selection is vital to ensure the best possible outcomes after transjugular intrahepatic portosystemic shunt (TIPS) insertion. However, data regarding the impact of intrapulmonary vascular dilatations…

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Negative / Null Result ReportOpen accessMedicine

Investigation of Potential Cross-Protection Conferred by the Seasonal Influenza Vaccine Against Swine Influenza A Viruses of Pandemic Potential.

Lilley A, Chiapponi C, Prosperi A et al. · 2026 · Vaccines

Background/Objectives : Influenza A viruses cause seasonal epidemics of respiratory infections in humans, the severity of which can be mitigated by influenza vaccine use. Influenza A viruses circulating in pigs continue to pose a pandemic…

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Negative / Null Result ReportOpen accessMedicine

Semaglutide use before single-level lumbar fusion associated with fewer readmissions and 90-day costs.

Ng MK, Mastrokostas PG, Rodriguez AN et al. · 2025 · Journal of craniovertebral junction & spine

Context Semaglutide, a glucagon-like protein-1 receptor agonist used in diabetes and obesity management, has demonstrated perioperative benefits in other surgical populations. However, its role in spine surgery remains unclear. Aims This…

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Negative / Null Result ReportOpen accessMedicine

The brief pain inventory-Interference Subscale has acceptable reliability but questionable validity in acute back and neck pain populations.

Jones CMP, Lin CC, Zadro J et al. · 2024 · Brazilian journal of physical therapy

Background The Brief Pain Inventory-Interference Subscale (BPI-IS) is a subscale of the BPI assessment tool developed to rapidly assess the impact of a person's pain on their function. It is uncertain whether it has one or two factors, and…

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