12,385 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Novik AV, Protsenko SA, Baldueva IA et al. · 2021 · The oncologist
Lessons learned Melatonin did not increase the efficacy of systemic chemotherapy in melanoma. Metformin did not increase the efficacy of systemic chemotherapy in melanoma. Background Current data support the possibility of antitumor…
View details →Galipienso-Eri M, Baraldés-Canals M, Aliaga-Martínez A et al. · 2025 · Indian journal of orthopaedics
Background/purpose Periprosthetic joint infection (PJI) accounts for up to 25% of failed total knee arthroplasties and 15% of the hips. The ICM18 established the criteria for the diagnosis, and the alpha-defensin lateral flow test (ADLT)…
View details →Saqib K, Goel V, Dubin JA et al. · 2026 · International journal of public health
Objective To examine differences in mental health-related healthcare utilization for anxiety and depression between individuals who did and did not undergo COVID-19 PCR testing in Ontario. Background: The COVID-19 pandemic has been…
View details →Gogebakan KC, Kunst N, Ghodsi A et al. · 2026 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The TheraP trial demonstrated that 177 Lu-PSMA-617 improved progression-free survival (PFS) compared with cabazitaxel, with no significant difference in overall survival (OS). However, 177 Lu-PSMA-617 was associated with fewer severe…
View details →Campo-Beamud C, Roig-Ferreruela G · 2026 · Archivos de la Sociedad Espanola de Oftalmologia
Blue light is a physiological component of visible light, essential for daytime vision and circadian synchronization. There is no evidence supporting the routine use of blue-blocking glasses for preventive or therapeutic purposes. The most…
View details →Marder SR, Eriksson H, Zhao Y et al. · 2020 · Acta neuropsychiatrica
Objective We provide a closer look at the result of a randomised, placebo-controlled, active-reference (quetiapine XR), flexible-dose, 6-week study of brexpiprazole in schizophrenia, which did not meet its primary endpoint - change from…
View details →Shah R, Das S, Gentile Kruse CF et al. · 2025 · Pediatric neurology
Background Triptans are used to treat migraine attacks, but little to no evidence supports their use for youth with post-traumatic headache (PTH). This study evaluated patterns of use and benefit of triptans in the treatment of acute…
View details →Roth MT, Cardin DB, Borazanci EH et al. · 2020 · The oncologist
Lessons learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the…
View details →Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…
View details →Park K, Özgüroğlu M, Vansteenkiste J et al. · 2021 · Lung cancer (Amsterdam, Netherlands)
Objectives The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects…
View details →Ponce H, Cordero R, Tran J et al. · 2025 · Journal of patient experience
In a prior study, communication scholar ratings of clinician communication effectiveness did not correlate with perceived clinician empathy, which is one aspect of patient experience. We repeated the analysis with a different rating of…
View details →Neter E, Youngmann R, Gruper N · 2025 · JMIR formative research
Unlabelled Associations between eHealth literacy and mental health literacy were examined; no significant association was identified between overall eHealth and mental health literacy and only weak associations between specific skills were…
View details →Pienkos S, Swank Z, Hamlin RE et al. · 2025 · Open forum infectious diseases
Plasma samples obtained approximately 3 ( n = 100) and 12 months ( n = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein…
View details →Wesley CD, Strange JE, Holt A et al. · 2025 · European heart journal open
Aims Fluoroquinolones (FQ) have been associated with aortic aneurysm and aortic dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this. Methods and results The current…
View details →Demattio L, Fietz D, Schuler G et al. · 2024 · Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
A 9.4 mg deslorelin slow-release implant was inserted into an adult, healthy billy goat to achieve temporary infertility and a reduction in sexual behavior. The implant was inserted in late autumn. No significant change in testis size was…
View details →Özçıbık Işık G, Turna A, Yurt S et al. · 2026 · Discover oncology
Objective Lung cancer is currently the leading cause of cancer-related death in men and the second most common cause in women worldwide. In the 9th edition of the TNM classification, N2 lymph node involvement has been divided into two…
View details →Choi, Gutman, Iglesia et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Studies have shown that sexual function improves after surgical correction for stress urinary incontinence and pelvic organ prolapse. Current data suggest no significant difference in sexual function between transobturator and retropubic…
View details →Shaygantabar, Dianati, Ledari et al. · 2026 · BMC pediatrics
Exclusive enteral nutrition (EEN) induces remission in children with active mild to moderate Crohn's disease (CD), while partial enteral nutrition (PEN) with a free diet have failed to be effective in these patients. The effects of CD…
View details →Caio Gonçalves de Souza, Márcio Passini Gonçalves de Souza, Vanda Jorgetti et al. · 2015 · Acta Ortopédica Brasileira
OBJECTIVE: To determine whether there is a difference on the bone architecture in patients with femoral neck fracture compared to patients with intertrochanteric fractures and assess the importance of aging on bone microarchitecture in patients with proximal femoral fracture.METHODS: Biopsy of the iliac crest was made in seventeen patients between 55 and 90 years old who were admitted to the emergency room with fractures of the proximal end of the femur. After a small fragment was removed, we made a histomorphometric analysis of it.RESULTS: There was no significant difference between patients
View details →Richard R. Chapleau, CharLee A. Martin, Summer R. Hughes et al. · 2019 · BMC Research Notes
Abstract Objective This study sought to determine if there is an association between variants in the apolipoprotein E (ApoE) promoter regions and development of white matter hyperintensities (WMH) in military subjects who have been exposed to high altitude. In an earlier study, we found that ApoE status did not correlate with WMH development, and here we hypothesized that regulation of APOE protein expression may be protective. Results Our cohort of 92 subjects encountered altitude exposures above 25,000 feet mean sea level through their occupations as pilots or altitude chamber technicians. U
View details →Kencono Viyati, Kinasih Prayuni, Yenni Zulhamidah et al. · 2023 · Makara Journal of Health Research
Background: Asthma is a multifactorial disease that encompasses a multitude of genetic and environmental factors. One such factor is the disintegrin and metalloprotein-33 (ADAM33) gene, which is correlated with asthma and bronchial hyperresponsiveness. Previous studies conducted on Asian populations have reported a significant association between rs2787094 polymorphism in the ADAM33 gene and asthma. Methods: Our study involved 153 Indonesian participants. TaqMan genotyping assay was used to analyze rs2787094 polymorphism in the ADAM33 gene. Results: No significant association was detected betw
View details →Seyed Mohammadreza Fatemi Khorasgani, Neda Ramezani, Negar Ebrahimi Varnousfaderani · 2020 · Journal of Research in Medical Sciences
Background: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic. Materials and Methods: In this case–control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control gr
View details →Ciaffi J, Bordini B, Cosentino M et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Osteoarthritis patients undergoing THA or TKA were studied to compare the cumulative incidence of revision after perioperative denosumab versus alendronate. Denosumab was not associated with differences in the incidence of revision after…
View details →LU Yongping, PAN Tingfang · 2025 · Jichu yixue yu linchuang
In order to cultivate interdisciplinary innovative medical talents who can adapt to the development of the needs of national medical care and of global file of medical education, Peking Union Medical College has initiated the project of the “4+4” model, which covers a series of education remodeling like candidate trainees’ enrollment, curriculum integration application of new teaching methods, assessment and evaluation, etc., and has made a great progress. The existing evaluation data show that there is no significant difference between the academic performance of students in the “4+4” trainin
View details →Azam Abed, Aliasghar Asghar Nezhad, Hamidreza Hatami · 2015 · Iranian Rehabilitation Journal
Objectives: The aim of current study was the evaluation and comparison of compatibility and marital satisfaction between handicapped couples and healthy ones. Methods: In this study, 50 handicapped couples and 50 healthy couples were examined with Enrich’s marital satisfaction questionnaire and Bell’s adjustment questionnaire. The data were analyzed, using SPSS 15, correlation tests and ANOVA. Results: The results showed that there was no significant difference between handicapped and healthy couples in compatibility and marital satisfaction. Discussion: It is concluded that people
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