e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,384 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Candida auris screening positivity after discontinuation of cohort units and enhanced nursing engagement: An interrupted time series.

Turner D, DeMaet MA, Bundage D et al. · 2026 · American journal of infection control

During an 87-week interrupted time series, we evaluated screening positivity after de-escalating dedicated cohort units for Candida auris and later implementing enhanced nursing engagement. Discontinuing cohort units did not increase…

View details →
Negative / Null Result ReportMedicine

Balancing risks in febrile hip fracture patients: is surgical delay more dangerous than infection?

Balziano S, Margalit I, Kollender R et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Fever often delays urgent hip fracture surgery due to infection concerns. This study found that operating early, despite fever, did not increase complications or death compared to waiting. Thus, early surgery appears to be a feasible…

View details →
Negative / Null Result ReportMedicine

Romosozumab does not improve volumetric bone mineral density at distal radius but is associated with early changes in bone strength: a prospective study.

Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…

View details →
Negative / Null Result ReportOpen accessMedicine

Clonal hematopoiesis in lung adenocarcinoma pathogenesis.

Parisi T, Santibanez Ocampo B, Adelman J et al. · 2026 · JCI insight

Age-related blood cell mutations (clonal hematopoiesis) reshape immune cells and lung tumor immune structures, but did not increase lung cancer growth in a genetically engineered mouse model. .

View details →
Negative / Null Result ReportOpen accessMedicine

Effects of Dietary Deoxynivalenol on Growth Performance, Immunity, Reproductive Hormones, and Microbiome-Metabolome Responses in Immature Gilts.

Li Z, Hu X, Feng H et al. · 2026 · Animals : an open access journal from MDPI

We evaluated the effects of different levels of DON (LD 441 and HD 1223 μg DON/kg in diet) on the growth performance, immunity, reproductive hormones, and intestinal health of immature gilts. No significant differences were observed in…

View details →
Negative / Null Result ReportMedicine

Sympathetic transduction to blood pressure following three days in hypobaric hypoxia: Influence of nocturnal periodic breathing.

Fisher JP, Roche J, Duffy AG et al. · 2026 · Autonomic neuroscience : basic & clinical

We investigated whether three days of hypoxic exposure in a hypobaric chamber, and the associated nocturnal periodic breathing (nPB), reduce sympathetic nerve activity (MSNA) transduction to blood pressure (BP). While hypoxia did not…

View details →
Negative / Null Result ReportMedicine

Comparing the effects of commercial to open initial specimen diversion techniques on clinical outcomes and institutional costs.

Yang EH, Lopez C, Shay SL et al. · 2026 · Infection control and hospital epidemiology

The clinical outcomes associated with using commercial versus open ISDTs (initial specimen diverting techniques) remain unclear. This multicenter study showed that switching from the commercial to open ISDT did not change blood culture…

View details →
Negative / Null Result ReportMedicine

Lights, Cameras, Action - The influence of lighting and camera position on walking and running kinematic measurements using Theia3D markerless motion capture.

Thomas A, Tucker CB, Lunn DE et al. · 2026 · Journal of biomechanics

Studies investigating the concurrent validity of markerless motion capture (MMC) systems for obtaining joint and segment kinematics have largely failed to consider the impact of ambient lighting and camera position, which can both affect…

View details →
Negative / Null Result ReportMedicine

Salt exposure disrupts memory retrieval in habituation and conditioned place preference in planaria (Dugesia japonica).

Tazumi T, Prados J, Urcelay GP · 2026 · Journal of comparative psychology (Washington, D.C. : 1983)

This study examined whether saline acts as an aversive stimulus for planarians and how it influences learning and memory. Using saline as an unconditioned stimulus, we first tested conditioned place avoidance. Saline did not support…

View details →
Negative / Null Result ReportMedicine

Long-term effects of almond consumption on cognitive performance and brain vascular function: a randomized crossover trial in overweight/obese adults with prediabetes.

Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition

Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…

View details →
Negative / Null Result ReportMedicine

Continuous Monitoring by a Wearable Sensor Did Not Enhance Discharge Decision-Making in an Acute Admission Ward: Results of a Randomized Controlled Trial.

Kant N, Garssen SH, Vernooij CA et al. · 2024 · Studies in health technology and informatics

Adding continuous monitoring to usual care at an acute admission ward did not have an effect on the proportion of patients safely discharged. Implementation challenges of continuous monitoring may have contributed to the lack of effect…

View details →
Negative / Null Result ReportMedicine

Did Not Wait Patients: Low-Risk for Admission and Deterioration.

Stewart D, Greenberg M, Heppell S et al. · 2025 · Emergency medicine Australasia : EMA

Objective To determine the proportion of patients who are admitted to hospital following a 'did not wait' (DNW) encounter that are related to the initial episode of care, and to assess the frequency of clinical deterioration in this…

View details →
Failed Experiment ReportMedicine

Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn's disease (ASTIClite): an open-label, multicentre, randomised controlled trial.

Lindsay JO, Hind D, Swaby L et al. · 2024 · The lancet. Gastroenterology & hepatology

Background A previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety…

View details →
Negative / Null Result ReportMedicine

Cardiovascular Outcomes in Adults with Coronary Artery Disease and Obstructive Sleep Apnea with versus without Excessive Daytime Sleepiness in the RICCADSA Cinical Trial.

Eulenburg C, Celik Y, Redline S et al. · 2023 · Annals of the American Thoracic Society

Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat…

View details →
Negative / Null Result ReportMedicine

Estimating the Opportunity for Early Detection of Ovarian Cancer Using Individual-Patient Data from a Large Randomized Controlled Trial.

Ryser MD, Holloway ST, Morsomme R et al. · 2025 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background The UK Collaborative Trial of Ovarian Cancer Screening did not detect a reduction in ovarian cancer mortality with either multimodal screening (MMS) or transvaginal ultrasound screening (USS) compared with no screening. The…

View details →
Negative / Null Result ReportOpen accessMedicine

Hemodynamic Effects of an Increased Midodrine Dosing Frequency.

Macielak SA, Vollmer NJ, Haddad NA et al. · 2021 · Critical care explorations

In practice, midodrine has been used to reduce IV vasopressor requirements and decrease ICU length of stay. However, recent publications have failed to show clinical success when midodrine was administered every 8 hours. One possible…

View details →
Negative / Null Result ReportOpen accessMedicine

The hazards of chasing subgroups in neutral stroke trials.

Bath PM, Howard G, Hacke W · 2025 · Neurological research and practice

Background The majority of randomised controlled trials in acute stroke and many for prevention are neutral, i.e. they failed to reach statistical significance. However, many of these will find apparent benefit in a component of a…

View details →