12,266 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kanazawa R, Goto R, Harada T et al. · 2024 · Scandinavian journal of immunology
Graft-infiltrating lymphocytes (GILs) play an important role in promoting rejection after organ transplantation. We recently reported that GILs that accumulated up to 3 days post-transplantation did not promote rejection, whereas GILs…
View details →Yang EH, Lopez C, Shay SL et al. · 2026 · Infection control and hospital epidemiology
The clinical outcomes associated with using commercial versus open ISDTs (initial specimen diverting techniques) remain unclear. This multicenter study showed that switching from the commercial to open ISDT did not change blood culture…
View details →Thomas A, Tucker CB, Lunn DE et al. · 2026 · Journal of biomechanics
Studies investigating the concurrent validity of markerless motion capture (MMC) systems for obtaining joint and segment kinematics have largely failed to consider the impact of ambient lighting and camera position, which can both affect…
View details →Tazumi T, Prados J, Urcelay GP · 2026 · Journal of comparative psychology (Washington, D.C. : 1983)
This study examined whether saline acts as an aversive stimulus for planarians and how it influences learning and memory. Using saline as an unconditioned stimulus, we first tested conditioned place avoidance. Saline did not support…
View details →Lee N, Yang Y, Tian D et al. · 2026 · Journal of ginseng research
We determined whether Korean Red Ginseng (KRG) extract and ginsenosides (Rb1, Rg1, or Rg3) have estrogen receptor-mediated or androgen receptor-mediated activities using OECD TG455/458 assays with S9 metabolic activation. They did not…
View details →Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition
Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…
View details →Kant N, Garssen SH, Vernooij CA et al. · 2024 · Studies in health technology and informatics
Adding continuous monitoring to usual care at an acute admission ward did not have an effect on the proportion of patients safely discharged. Implementation challenges of continuous monitoring may have contributed to the lack of effect…
View details →Sanders JF, de Boer SE, Jonker J et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in older kidney transplant recipients. Low-dose tacrolimus, everolimus, and prednisolone did not result in better…
View details →Hüther A, Sherman CL, Sumaroka A et al. · 2026 · Ophthalmic genetics
Purpose To describe the phenotype of a patient with bi-allelic pathogenic variants in NR2E3 that did not result in an overt enhanced S-cone syndrome (ESCS) phenotype. Methods The patient underwent a comprehensive ophthalmic exam, imaging…
View details →Wu C, Zhu X, Dai Q et al. · 2026 · Chest
Case presentation A 74-year-old woman sought treatment with a 4-day history of high fever and rapidly progressive dyspnea. A 2-day course of ceftriaxone and betamethasone administered in an outpatient setting did not result in any clinical…
View details →Stewart D, Greenberg M, Heppell S et al. · 2025 · Emergency medicine Australasia : EMA
Objective To determine the proportion of patients who are admitted to hospital following a 'did not wait' (DNW) encounter that are related to the initial episode of care, and to assess the frequency of clinical deterioration in this…
View details →Roveri V, Souza UP, da Costa JHA et al. · 2025 · Data in brief
Null results are rarely reported yet are essential to establish realistic baselines for marine-seafood contamination. This dataset documents the first attempt to detect 17 widely used pharmaceuticals in edible tissues (muscle and liver) of…
View details →Dora J, Kuczynski AM, McCabe CJ et al. · 2026 · Journal of psychopathology and clinical science
Etiological models of alcohol and cannabis use disorders hypothesize that people are more likely to use substances when experiencing heightened negative affect, yet recent Ecological Momentary Assessment (EMA) studies found no evidence for…
View details →Lindsay JO, Hind D, Swaby L et al. · 2024 · The lancet. Gastroenterology & hepatology
Background A previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety…
View details →Finkelstein A, Cantor JC, Gubb J et al. · 2024 · Health affairs (Project Hope)
When a randomized evaluation finds null results, it is important to understand why. We investigated two very different explanations for the finding from a randomized evaluation that the Camden Coalition's influential care management…
View details →Eulenburg C, Celik Y, Redline S et al. · 2023 · Annals of the American Thoracic Society
Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat…
View details →Ryser MD, Holloway ST, Morsomme R et al. · 2025 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background The UK Collaborative Trial of Ovarian Cancer Screening did not detect a reduction in ovarian cancer mortality with either multimodal screening (MMS) or transvaginal ultrasound screening (USS) compared with no screening. The…
View details →Macielak SA, Vollmer NJ, Haddad NA et al. · 2021 · Critical care explorations
In practice, midodrine has been used to reduce IV vasopressor requirements and decrease ICU length of stay. However, recent publications have failed to show clinical success when midodrine was administered every 8 hours. One possible…
View details →Sameed M, Meng Z, Marciniak ET · 2019 · Breathe (Sheffield, England)
In the EOLIA trial, early use of ECMO did not significantly improve mortality at 60 days in patients with severe ARDS, but when used as a rescue modality ECMO might help improve survival http://bit.ly/2XOjwSE.
View details →Bath PM, Howard G, Hacke W · 2025 · Neurological research and practice
Background The majority of randomised controlled trials in acute stroke and many for prevention are neutral, i.e. they failed to reach statistical significance. However, many of these will find apparent benefit in a component of a…
View details →Novik AV, Protsenko SA, Baldueva IA et al. · 2021 · The oncologist
Lessons learned Melatonin did not increase the efficacy of systemic chemotherapy in melanoma. Metformin did not increase the efficacy of systemic chemotherapy in melanoma. Background Current data support the possibility of antitumor…
View details →Galipienso-Eri M, Baraldés-Canals M, Aliaga-Martínez A et al. · 2025 · Indian journal of orthopaedics
Background/purpose Periprosthetic joint infection (PJI) accounts for up to 25% of failed total knee arthroplasties and 15% of the hips. The ICM18 established the criteria for the diagnosis, and the alpha-defensin lateral flow test (ADLT)…
View details →Saqib K, Goel V, Dubin JA et al. · 2026 · International journal of public health
Objective To examine differences in mental health-related healthcare utilization for anxiety and depression between individuals who did and did not undergo COVID-19 PCR testing in Ontario. Background: The COVID-19 pandemic has been…
View details →Gogebakan KC, Kunst N, Ghodsi A et al. · 2026 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The TheraP trial demonstrated that 177 Lu-PSMA-617 improved progression-free survival (PFS) compared with cabazitaxel, with no significant difference in overall survival (OS). However, 177 Lu-PSMA-617 was associated with fewer severe…
View details →Campo-Beamud C, Roig-Ferreruela G · 2026 · Archivos de la Sociedad Espanola de Oftalmologia
Blue light is a physiological component of visible light, essential for daytime vision and circadian synchronization. There is no evidence supporting the routine use of blue-blocking glasses for preventive or therapeutic purposes. The most…
View details →Marder SR, Eriksson H, Zhao Y et al. · 2020 · Acta neuropsychiatrica
Objective We provide a closer look at the result of a randomised, placebo-controlled, active-reference (quetiapine XR), flexible-dose, 6-week study of brexpiprazole in schizophrenia, which did not meet its primary endpoint - change from…
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